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Biomedical subjects

O S Kantor

Publications and source records attributed to O S Kantor.

8 recordsLinked to original sources
PubMed1988

Successful management of catastrophic gastrointestinal involvement in polyarteritis nodosa.

A patient with polyarteritis nodosa developed necrotizing enterocolitis, as indicated by pneumatosis intestinalis seen on computed tomographic scans of the abdomen. Despite immunosuppressive therapy and concomitant resolution of the intramural and portal venous gas and general clinical improvement, on 2 occasions (between 20 and 30 days later) the patient developed bowel infarctions and perforations that necessitated bowel resection. Leaks developed at anastomotic sites, but were not closed surgically. However, these sites and the lower quadrants of the abdomen were drained, and the patient was given total parenteral nutrition. Over a 2-month period the patient completely recovered from this nearly always fatal gastrointestinal complication of polyarteritis nodosa. The medical, surgical, and radiographic approach we used may be applicable to the management of similar cases in the future.

Biopsy↗
PubMed1987

Fatal pneumonia in an adult due to respiratory syncytial virus.

Respiratory syncytial virus (RSV) infections in adults are generally mild, and no fatalities in uninstitutionalized adults have been reported. To our knowledge, we document herein the first case of fatal RSV pneumonia in a previously healthy elderly woman living at home, in whom complement fixation titers against RSV rose from less than 1:8 to reach 1:256 at death. Cytoplasmic inclusions characteristic of RSV were detected at autopsy.

Aged↗
PubMed1975

Azathioprine plus prednisone compared with prednisone alone in the treatment of systemic lupus erythematosus. Report of a prospective controlled trial in 24 patients.

A prospective, randomized drug trial compared prednisone (60 mg per day initially) to azathioprine (3 to 4 mg/kg of body weight - day initially) plus prednisone in 24 patients with life-threatening systemic lupus erythematosus. Each group contained patients matched for age, sex, disease duration, previous therapy, and clinical and laboratory features of lupus erythematosus. During a mean follow-up period of 18 to 24 months, there were no significant differences between the two groups in number of deaths, renal or extrarenal manifestations of disease, serum complement levels, DNA antibodies, antinuclear antibody titers, lupus erythematosus cells, or Coombs' antibodies. There was no convincing evidence of a steroid-sparing effect of azathioprine. Side effects attributable to steroids were equally common in both groups; infections were not increased in the combination therapy group. Azathioprine was hepatotoxic in doses of 200 mg daily or more. Azathioprine was not a useful adjunct to corticosterolds in short-term therapy of a small number of patients with severe systemic lupus.

Adolescent↗
PubMed1975

Jaccoud arthritis.

Jaccoud polyarthritis is thought to be a rare complication of rheumatic fever. It is characterized by severe rheumatic fever, with repetitive or prolonged attacks, associated with a painless, but deforming arthritis affecting the small joints of hand and feet. Radiologically, erosion of the metacarpal heads may be present. All described cases have shown obvious rheumatic heart disease. Two patients had the clinical and radiographic features of Jaccoud arthropathy who had no antecedent history of rheumatic fever. Jaccoud arthropathy may have diverse causes.

Arthritis↗
PubMedDate not supplied

Adverse reactions associated with ticrynafen use.

Three hypertensive patients receiving ticrynafen, a new uricosuric diuretic, experienced adverse reactions. One patient experienced acute renal failure, the second experienced a renal stone, and the third had a fatal hemorrhage while receiving anticoagulation therapy with warfarin sodium. All complications can be explained by known actions of the drug and are preventable. However, these reactions illustrate the potential hazards from widespread substitution of ticrynafen for thiazide diuretics in the treatment of hypertension.

Acute Kidney Injury↗