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Biomedical subjects

O S Kulikova

Publications and source records attributed to O S Kulikova.

10 recordsLinked to original sources
PubMed1990

[Effects of thermal factors on the state of microcirculation of the small intestine in acute ischemia].

The influence of normo- (38 degrees C), hyper- (42 degrees C) and hypothermia (20 degrees C) on microcirculatory disturbances caused by acute local ischemia of the small intestine was investigated with the help of biomicroscopy as well as morphological methods. Ischemia was modeled by ligation of the intestine look eventrated through the abdominal wall incision of a rat onto the microscope stage for 1 h. It was shown that hyperthermia intensified microcirculatory disorders and stimulated destructive processes in tissues and hypothermia promoting microcirculation and decreasing metabolism and restrained the development of these processes. Important peculiarity of the microvascular response to ischemia, hyper- and hypothermia was revealed: heterogeneity of the reaction of different parts of microvascular bed. Appropriate evaluation of the microcirculation state in such conditions can be obtained taking into account not only the qualitative character of microvascular reaction but also an extent of this reaction manifestation in different parts of microvascular bed.

Animals↗
PubMed1989

[A study of the features of E. coli bacteroid infection in experiments on mice].

Experiments on the intraperitoneal infection of F1 (CBA X C57BL/6) mice with bacteroids of the group Fragilis in combination with E. coli have revealed the presence of a synergic effect leading to more pronounced (greater frequency of abscess formation) and even qualitatively new (necrotic lesions of the liver) pathological changes in comparison with those observed in monoinfections. Bacteroides fragilis strain 1/1087 gamma has been shown to have greater virulence than that of Bacteroides vulgaris strain 18; their virulence was determined from the capacity of microorganisms for survival in the abdominal cavity of mice, as well as from their capacity for inducing the formation of necrotic lesions and abscesses.

Animals↗
PubMedDate not supplied

[Influence of cell therapy and alimentary correction on the condition of microcirculatory system in experimental dyslipidemia].

A comparative analysis of the impact of cell therapy (allogenic fetal liver cells, stem cells of autologic bone marrow) on lipid homeostasis, microcirculatory disturbances and structural changes in some organs was made using the atherosclerosis model in guinea-pigs. A positive effect of cell therapy on these parameters was established. The effect was stronger and prolonged after transplantation of stem cells. Atherogenic diet weakens the effect of cell therapy. Thus, cell therapy is more effective in restriction of atherogenic risk factors.

Animals↗
PubMedDate not supplied

[Detection of latent spontaneous pathology of the central nervous system and visceral organs in rabbits by determining antibodies to tissue antigens and by a test for delayed hypersensitivity].

Complex immunological, pathologicoanatomic and histopathological examination of intact rabbits revealed a correlation between the appearance of complement fixation antibodies and delayed hypersensitivity to tissue antigens on the one hand and the development of spontaneous pathology of the corresponding organs on the other. Meningoencephalitis was diagnosed in all sick animals by means of immunological tests. Tests for antibodies and delayed hypersensitivity to tissue antigens revealed intracapillary glomerulonephritis, coccidiosis of the liver, and pneumonia. The authors recommend conduction of immunological tests for detecting latent spontaneous pathology in laboratory animals.

Animals↗