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Biomedical subjects

O S Misharev

Publications and source records attributed to O S Misharev.

At least 19 recordsLinked to original sources

[Postoperative peritonitis in children].

The peculiarities of the manifestation of progressive and postoperative peritonitis under conditions of intensive postoperative therapy are shown on basis of generalized experience in the treatment of 48 children who underwent early relaparotomy for postoperative complications. The following causes of purulent peritonitis were determined during relaparotomy: progressive peritonitis in 14, postoperative peritonitis in 30, incompetence of the intestinal sutures in 9, and perforating ulcers of the small intestine in 3 patients. Manifestations of postoperative peritonitis in 13 patients (group I) treated in the intensive care department after operation for peritonitis of appendicular origin in whom the early postoperative period was uneventful were compared with those in 12 patients (group II) who were in the intensive care department after the first operation and who were later subjected to early relaparotomy. Besides the well-known manifestations of purulent peritonitis complicating an operation on the abdominal organs, other objective signs characterizing the peculiarities of intensive therapy were revealed. Among them are increased volume of the stagnant gastric contents and increased volume and doses of corrective therapy for the control of dehydration and hypokalemia. To correct dehydration and loss of potassium during intensive therapy, much more solutions and potassium must be administered than in children with an uneventful postoperative course.

Adolescent↗

[Disseminated intravascular coagulation in newborn infants with infection].

The treatment of disseminated intravascular coagulation (DIC) in infants with sepsis should be instituted after multimodality therapy of pyo-inflammatory diseases taking into account the degree of hemostatic disorders. In stage I DIC (hypercoagulation one), it is necessary to reach an adequate level of the inhibitors of the thrombin and plasmin systems. In this case it is quite sufficient to use donor's cryoplasma without heparin administration. In stage II DIC (transitory one) and stage III (hypocoagulation one), it is required that the drugs possessing antithrombin and antiplasmin activity, substitution therapy with blood preparations and components as well as measures to control hemorrhagic diathesis may be used.

Antithrombins↗

[Diagnosis and surgical treatment of gastroesophageal reflux in children].

Results of observations examination and treatment of 115 children with gastroesophageal reflux aged from 3 days to 14 years are described. Great importance of special methods of examination was shown. Results of using the roentgenological method, fibroesophagogastroscopy with biopsy of the esophagus, manometry and electromyography of the esophagus are presented. Specific features and results of the surgical treatment of the disease are described.

Adolescent↗

[Indications for using heparin in diffuse suppurative peritonitis in children].

In non-complicated course of diffuse purulent peritonitis in children the anti-thrombin (frozen plasma) drugs are thought by the authors to be sufficient for purposeful correction of disturbed hemostasis in children. The appearance of laboratory signs of IDS and clinical manifestations of functional insufficiency of parenchymal organs are considered to be an indication to use frozen plasma and heparin irrespective of previous operations.

Child↗

[Ligation of the esophagus in hemorrhage resulting from portal hypertension in children].

The authors present a technique of the operation described by Vosschulte and Boerema and aimed at ligation of the esophagus for prophylaxis and arrest of hemorrhage from esophageal varices. "Collapsible prostheses" were used in 8 operations on 7 patients. In primary interventions the authors proposed laparotomy giving a good possibility for manipulations on the esophagocardial portion of the stomach. In secondary operations a transthoracic access with diaphragmotomy was used. The most frequent complication--scarry constriction of the esophagus--can be easily eliminated due to timely diagnosis and cardiodilatation. No recurrent bleedings were noted. The endoscopic and X-ray examinations failed to reveal esophageal varices.

Adolescent↗

[Conservative treatment of intestinal invagination in children].

A new method of the conservative treatment of intussusceptions in children by hydrostatic disinvagination with the help of barium enema is described. The durability of the colon was shown to change proportionally to its tone. To make the conservative treatment more efficient and to prevent a perforation of the colon the hydrostatic pressure should depend on the colon tone. Out of 48 patients with acute intestinal invagination 46 children were cured by this method including 2 children with small intestine invagination. In this group of patients there were neither complications nor lethal outcomes.

Barium Sulfate↗