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Biomedical subjects

O S Nasonkin

Publications and source records attributed to O S Nasonkin.

At least 19 recordsLinked to original sources
PubMed1992

[A procedure for infusion-transfusion therapy and autohemodilution in severe trauma and shock (apropos the article by B. N. Salamatin et al., The use of the "internal autotransfusion" method in complex shock-control measures at the prehospital stage)].

The infusion of hypertonic solution is thought by the authors to be effective due to its reflectory action for treatment of patients who are in the state of anaphylactic and cardiogenic shock. This method seems to be expedient for massive blood loss under conditions of prehospital medical aid to victims with very low level of arterial pressure, with craniocerebral trauma and critical trauma of the chest.

Blood Transfusion, Autologous↗
PubMed1989

[Quantitative evaluation of the nitroblue tetrazolium reduction test].

The results of NBT test were assessed by the visual cytochemical method and by the quantitative spectrophotometry technique developed by the authors for the NBT test. The results demonstrate a higher sensitivity and informative value of the new method, in case the neutrophilic tetrazolium activity is rather high; this recommends the NBT test spectrophotometric variant for wide clinical application in studies of the blood leukocyte functional and metabolic activity.

Blood Bactericidal Activity↗
PubMed1989

[Endotoxemia as a problem of clinical surgery].

The authors have formulated a modern concept of endotoxicosis. The ideas of its essence were formed on the clinical model of the severe associated mechanical trauma. Principles of the complex treatment of endotoxicosis are described.

Endotoxins↗
PubMed1988

[Status of the blood coagulation system in traumatic disease].

Under examination there were 198 patients with severe mechanical traumas at their admission to the clinic and on the 1st, 3d, 7th, 14th and 21st days by 25 hemocoagulation parameters determined by common present-day methods. The direction and degree of hemocoagulation alterations were found to be related with the severity of trauma, blood loss volume and severity of shock. It was shown that disseminated intravascular coagulation (DIC) of the II and III degree was developing in critical associated traumas, massive blood loss and severe shock in acute period of the disease. The acute form of DIC with reactive fibrinolysis was established in the lethal outcome during the shock period, latent (slow) DIC with local fibrinolysis took place in lethal outcomes in later periods.

Adolescent↗
PubMed1984

[Traumatic disease and metabolism].

The authors have established that the traumatic disease is accompanied by phasic nonspecific changes of metabolism correlating with the trauma severity as well as with its specific features and outcomes. Within the first 3-7 days catabolic processes are found to prevail and metabolic acidosis develop. Later, anabolic processes become activated in the non-complicated course of the disease. Normalization of most biochemical processes is accomplished within 15-21 days. More pronounced and prolonged disturbances of metabolism are observed in complications and lethal outcomes.

Acidosis↗
PubMed1983

[Cerebral evoked potentials in comatose states of various etiology].

The authors studied the evoked potentials (EPs) of the brain cortex in patients in comatose states of various etiology as well as the EPs of the brain cortical and subcortical structures of the animals during simulation of the conditions studied in clinical practice. A sharp drop in the amplitude of early waves and an increase in the amplitude and latency of late EP waves in all the cerebral structures irrespective of the coma genesis were disclosed. The changes were of a simultaneous and generalized character with a greater similarity between the EPs of the cortical zones but an increase of their difference from the subcortical structures. These facts are explained by the deprivation of the nonspecific systems of both cortical and local inhibitory influence which leads to the late activation of the brain specific systems. It is assumed that the space-time dissociation in the action of various cerebral systems is, regardless of the coma genesis, one of the principal mechanisms giving rise to disorders of information perception, analysis and processing.

Animals↗