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O Saxtrup

Publications and source records attributed to O Saxtrup.

8 recordsLinked to original sources
PubMed2000

On the use of regression analysis for the estimation of human biological age.

The present investigation compares three linear regression procedures for the definition of human biological age (bioage). As a model system for bioage definition is used the variations with age of blood hemoglobin (B-hemoglobin) in males in the age range 50-95 years. The bioage measures compared are: 1: P-bioage; defined from regression of chronological age on B-hemoglobin results. 2: AC-bioage; obtained by indirect regression, using in reverse the equation describing the regression of B-hemoglobin on age in a reference population. 3: BC-bioage; defined by orthogonal regression on the reference regression line of B-hemoglobin on age. It is demonstrated that the P-bioage measure gives an overestimation of the bioage in the younger and an underestimation in the older individuals. This 'regression to the mean' is avoided using the indirect regression procedures. Here the relatively low SD of the BC-bioage measure results from the inclusion of individual chronological age in the orthogonal regression procedure. Observations on male blood donors illustrates the variation of the AC- and BC-bioage measures in the individual.

Aged↗
PubMed1998

On the use of patient data for the definition of reference intervals in clinical chemistry.

To improve the definition of reference intervals using patient data in clinical chemistry we studied the use of single results as a selection criterion (i.e. those results judged by the clinician not to require confirmation or which are considered unimportant for clinical screening purposes). Using this criterion 95% intervals were defined for S-albumin, S-cholesterol, S-creatinine, B-glucose, B-haemoglobin and S-urea similar to the corresponding reference intervals determined for healthy adults. Data collected from patients in the age interval 45-95 years demonstrated a significant decrease in levels of S-albumin and B-haemoglobin with age, an increase in S-creatinine, B-glucose and S-urea levels, and a biphasic variation in level of S-cholesterol. It is suggested that these changes are not caused by disease but result from the ageing process. The use of selected patient data for characterization of these changes enables a linear or polynomial description to be made for the age-related changes in the reference intervals.

Adolescent↗
PubMed1982

Quantitated determination of proteins in perilymph in patients with acoustic neuromas.

Perilymph, cerebrospinal fluid (CSF) and plasma from 19 patients with acoustic neuromas were examined for albumin, alpha 2-macroglobulin and IgG. Patients with otosclerosis were used as controls. A highly significant increase of the tested proteins was found in perilymph from patients with acoustic neuromas. Determination of the tau-transferrin, which is a specific CNS protein, could neither be demonstrated in plasma nor in perilymph. This is in favour of the assumption that perilymph is plasma-derived and not concentrated CSF. Various causes for the high protein concentrations are discussed, and it is suggested that the increase is caused by a blockage of the neuroaxonal transport mechanisms.

Adult↗
PubMed1982

Spinal proteins in patients with acoustic neuromas.

The values of total spinal protein in cerebrospinal fluid (CSF), used as normal material, from 98 persons are presented. These values showed that the previously used reference limits (0.20-0.40 g/l) for total protein in CSF were too low, and consequently the new reference values 0.20-0.85 g/l are used. 77 patients with surgically verified acoustic neuromas had total protein determined in CSF prior to operation, and 63% of patients with tumours less than 25 mm in diameter had normal total protein values, while only 3% of patients with tumours larger than 25 mm had normal values. Since the large tumours can be easily diagnosed by the non-invasive computer tomography, it is concluded that CSF total protein determination is only of limited value in the search for acoustic neuromas. A more quantitated examination of CSF proteins (albumin, alpha 2-macroglobulin, IgA, IgG and IgM) showed significantly increased values among the tumour patients, but the findings were not of any significant clinical value in the diagnosis of tumours.

Albumins↗
PubMed1981

Evoked potentials and immunoglobulin abnormalities in multiple sclerosis.

We studied 80 patients with definite, probable, or possible multiple sclerosis, using visual and somatosensory evoked cortical potentials as indicators of manifest or silent plaques. The findings were related to the intracerebral production of immunoglobulin G expressed by the CSF IgG index. Combining the results of evoked potentials and cerebrospinal fluid (CSF) findings, the patients were reclassified. Eight of 18 patients with clinically probable multiple sclerosis were then deemed definite, and 17 of the 42 possible cases were deemed probable. No relation was found between the presumed number of lesions and the rate of intracerebral IgG synthesis.

Adult↗
PubMed1981

Pseudothrombocytopenia. In vitro studies on the underlying mechanism.

In a prospective 9 month study at a medical department with special interest in immunology and rheumatology, 10 patients with spuriously low thrombocyte counts - pseudothrombocytopenia - were registered. The phenomenon was observed when the counting of platelets was performed on a Thrombocounter C apparatus or by manual counting using K2EDTA stabilized blood since platelet agglutination was considerably less pronounced when solution citratis glucosi fortis (ACD) was used as the anticoagulant. Results of our in vitro studies indicate that the mechanisms contributing to pseudothrombocytopenia involve the interaction of circulating immune complexes with platelet membrane Fc receptors causing agglutination. Fab'2-fragments of isolated patient IgG did not react with normal donor thrombocytes. This finding argues against agglutination due to true antiplatelet antibody activity.

Adult↗
PubMedDate not supplied

Prognostic significance of birth of large infant for subsequent development of maternal non-insulin-dependent diabetes mellitus: a prospective study over 20-27 years.

In a prospective study, 270 women who gave birth to infants weighing greater than or equal to 4500 g (large baby, LB) underwent an oral glucose tolerance test (OGTT) within the first week of the puerperium. Of these women, 179 (66.3%) were retested 3-10 yr later, and 236 (87.4%) were also evaluated 20-27 yr later. The frequency of pathologic OGTTs increased with time, but the tests were of little prognostic significance for the individual patient. Women who had borne LBs developed non-insulin-dependent diabetes mellitus (NIDDM) six times more often than did a control group of women matched for age and parity and with the same period of follow-up. However, patients who developed NIDDM were also very obese, of high parity, and had a positive family history for diabetes mellitus in a high percentage of cases. Women with LBs as the only risk factor did not develop NIDDM in our study. We conclude that the birth of one LB is of minor, if any, importance in the subsequent development of NIDDM.

Adult↗