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O Scheel

Publications and source records attributed to O Scheel.

49 records · Page 3Linked to original sources
PubMed1993

Epidemiological aspects of community-acquired and hospital-acquired bacteremia in northern Norway.

389 patients with 401 bacteremic episodes, either community-acquired (CAB) or hospital-acquired (HAB), admitted to the University Hospital of Tromsø (UHT), Norway, and 3 small local hospitals in the region (LHs), were reviewed on the basis of data collected in 1985 and 1989. As regards incidence, sex- and age distribution, distribution to either surgical, medical, or pediatric wards, compared with etiological agents and predisposing factors, the statistical significance has been evaluated. The proportion of patients < 50 years was greater at UHT than in the LHs. More patients with HAB associated with predisposing factors were hospitalized at UHT than at the LHs. Coagulase-negative staphylococci occurred less frequently in bacteremic patients at UHT than at the LHs. As opposed to reports from elsewhere, Tromsø University Hospital seems to appear much more similar to the smaller local hospitals in the epidemiological aspects of bacteremia, inasmuch as both HAB and the CAB presented an even distribution pattern between the 2 hospital groups.

Adolescent↗
PubMed1993

Susceptibility pattern of Scandinavian Francisella tularensis isolates with regard to oral and parenteral antimicrobial agents.

Some recently introduced antimicrobial agents have only been incompletely evaluated for use in Francisella tularensis infections. The present study evaluated the susceptibility pattern of Scandinavian human, rodent, and hare F. tularensis isolates with respect to a selection of traditional as well as recently introduced antimicrobial agents. All strains were resistant to the following beta-lactams: penicillin, cephalexin, cefuroxime, ceftazidime, aztreonam, imipenem, and meropenem with minimal inhibitory concentrations > 32 mg/l. Against macrolides, a mixed susceptibility/resistance pattern appeared. All strains were susceptible to gentamicin, chloramphenicol, doxycycline, and four quinolones. Since the quinolones showed the lowest MIC values, and in addition give a good intracellular penetration, we conclude that future drugs to consider against tularemia should definitely include this group of antibiotics. The outpatient mode of antibiotic treatment is especially relevant as the Scandinavian variant of F. tularensis infection is nonlethal, usually pustuloglandular, and not septicemic. Therefore, oral drugs must be sought, and the quinolone group also satisfies this requirement.

Administration, Oral↗
PubMed1992

[Tularemia in Norway. A clinical and epidemiological review].

Altogether 105 cases of tularemia were reported to the nationwide notification system for infectious diseases (MSIS) in Norway during the period 1975-90. The zoonosis appears every year in Northern Norway. The first epidemic outbreak was reported from Central Norway in 1984-85. During the nineteen eighties the disease has reappeared in Southern Norway. We review the clinical features and epidemiological patterns of tularemia in Norway. Preliminary investigations indicate that the future drug of choice for treatment of tularemia is one of the gyrase-inhibitors.

Adolescent↗
PubMed1992

Treatment of tularemia with ciprofloxacin.

A case of tularemia which occurred after close contact with a cat is presented. After unsuccessful amoxicillin treatment, a two-week course of doxycycline was given whereupon the patient responded well. However, the patient relapsed shortly after and was then given ciprofloxacin for two weeks. The patient then recovered completely. Clinical trials are needed in order to establish whether a quinolone could be the drug of choice for treatment of tularemia.

Adult↗
PubMed1992

Spread of subclinical Chlamydia pneumoniae infection in a closed community.

Chlamydia pneumoniae infections may spread subclinically. The present investigation took place in a military setting. Sera drawn when the conscripts had entered their military service 2 months previously had been kept frozen and were available. In a camp with 500 people, 35 (7%) developed clinical symptoms of pneumonia. The infection was serologically verified with C. pneumoniae-specific micro-immunofluorescence technique. Of 40 healthy controls, 21 turned out to fulfil the serological criteria of infection, thus, representing subclinical cases. These 21 cases, when extrapolated to the whole camp, equalled a rate of 49% which, added to the 7% of pneumonic cases, gave a total infection rate of 56%. Pre-existing IgG antibodies were demonstrated in 10% of the pneumonic cases, 48% of the subclinical cases, and 89% of the non-infected, healthy controls. Without the access to pre-epidemic sera permitting us to establish 4-fold titre rises, the spread of subclinical C. pneumoniae infection would have been noted at 5%, and not 49% as here demonstrated.

Adult↗
PubMed1991

[Bacterial endocarditis after treatment by a natural healer].

We describe a case of endocarditis caused by Propionibacterium acnes after a series of 'vitamin' injections and semipermanent acupuncture needle maneuvers by a natural healer. The patient had prosthetic heart valves. We found that the most probable source of infection was the treatment by the natural healer and therefore wish to warn against invasive treatment of such high-risk patients by laymen. If such treatment is insisted upon in spite of such warnings, antibiotic prophylaxis should be considered.

Acupuncture Therapy↗
PubMed1991

Resistant strains isolated from bacteremia patients in northern Norway.

Bacterial isolates from blood cultures in 1985 and 1989 (227 and 258 isolates, respectively), were compared as regards resistance to a series of antimicrobial agents including the more recent beta-lactams and quinolones. An increase in the number of coagulase-negative staphylococcal strains and a decrease in Staphylococcus aureus strains were detected, otherwise there were no significant differences in the bacterial patterns in 1985 compared to 1989. Except for chloramphenicol, there was no major increase in antimicrobial resistance among Gram-negative species. An increase in the number of multiresistant enterobacteriaceae strains was due to an increased number of klebsiella strains and a decrease in Proteus mirabilis. S. aureus showed an increased resistance to sulfonamides. No methicillin-resistant strain was found. Coagulase-negative staphylococci were significantly more often multiresistant in 1989 than in 1985, and significant increase in resistance to gentamicin, sulfonamides and fusidic acid was found.

Anti-Bacterial Agents↗
PubMed1989

Significance of immunoglobulin A titres in the diagnosis of urogenital chlamydial infections.

The significance of chlamydial serum IgA compared with IgM and IgG in the diagnosis of urogenital chlamydial infection was evaluated using 120 sera from different categories of patients. In urethritis patients both IgM and IgA antibodies were not found to be present consistently, whereas in patients with deep-seated chlamydial infection, IgA was more often present. Although of limited value in superficial infections, demonstration of IgA antibodies may be of value in the diagnosis of deep-seated chlamydial infections.

Adolescent↗
PubMedDate not supplied

Water- and airborne Francisella tularensis biovar palaearctica isolated from human blood.

The isolation of Francisella tularensis from human blood is extremely rare in Europe. We here describe two cases of septicemia caused by F. tularensis biovar palaearctica, where the causative bacterium was isolated from blood. One of our patients had ingested contaminated water; the other was probably infected by inhalation of contaminated dust. The isolation of the causative organism was essential for initiating the appropriate antibiotic treatment, which led to a rapid improvement. Since the responsive agent rarely is isolated from tularemia patients, blood cultures should be drawn more often in order to improve the diagnostic procedures.

Adult↗