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Biomedical subjects

O Scherak

Publications and source records attributed to O Scherak.

At least 73 records · Page 4Linked to original sources
PubMed1976

Influence of diftalone on tolbutamide test and i.v. glucose tolerance test.

In 16 healthy volunteers tolbutamide tests or i.v. glucose tolerance tests were performed with and without previous oral administration of 1000 mg diftalone. Blood sugar and serum insulin were assayed in regular intervals. Both with and without previous administration of diftalone blood glucose after tolbutamide did not show any difference. IRI response to tolbutamide, measured by planimetrical integration showed a statistically significant augmentation (0.05 greater than p greater than 0.01) after diftalone. Glucose assimilation (K-value) after diftalone was decreased (0.05 greater than p greater than 0.01) yet within normal range. For the accompanying insulin levels however no statistically significant difference was observed. In addition a normalisation of pathological tolbutamide test after diftalone could be noted in five patients with subclinical diabetes. Our results indicate that diftalone seems to have the following three actions: 1. Enhancement of the tolbutamide action. 2. direct augmentation of IRI secretion, 3. a peripheral action on glucose metabolism.

Adult↗
PubMed1976

[Technetium uptake in the parotid gland. Value of functional parameters in Sjögren's syndrome].

Studies of the parotid function were performed on 22 subjects comprising 11 patients with Sjögren's syndrome and 11 normal controls using an Anger camera with digital data processing facility. After injection of 2 mCi of 99mTc-pertechnetate digital scintigrams of the face region were collected and stored onto magnetic tape. 50 minutes after injection the parotid glands were stimulated by administration of Pilocarpin. By subsequent processing of the data uptake curves were obtained for both parotid glands. In allowing for vascular activity three different methods were compared. The most satisfactory method with respect to discriminating the groups under study was using a background region located in the falx cerebri. From the corrected uptake curves a number of parameters were derived and their respective selectivity was investigated by statistical analysis. It is shown that the most suitable parameter characterizing the parotid function is given by the difference of maximum uptake before Pilocarpin stimulation and minimum uptake after stimulation.

Humans↗
PubMed1975

[Preliminary results with a new non-steroidal antirheumatic drug (author's transl)].

Thirty patients with classical or definite rheumatoid arthritis were treated over a 4-week period with diftalone, a new non-steroidal antirheumatic drug. The daily dosage ranged from 500 to 1000 mg. A good objective response was achieved in 69% of the patients. Diftalone was well tolerated. Side effects were noted in 11.8% of patients on 500 mg diftalone daily and in 18.8% of cases treated with the highest dosage (1000 mg daily). The optimum daily dosage appears to be 750 mg.

Administration, Oral↗
PubMed1975

[Ga-67 citrate scanning in the management of Hodgkin's disease (author's transl)].

159 potential areas of involvement in 26 patients with histologically proven Hodgkin's disease were examined by Ga-67 scanning. 137 areas (86%) were correctly assessed. An uptake was noted in 29 of 48 areas with active diseases, no uptake in 108 of 111 areas without active disease (97%). Best results were obtained from scans of mediastinum and lungs, particularly for differentiating between active disease and fibrosis. Para-aortic and pelvic regions often gave false-positive results because of the elimination of the tracer substance via the large bowel. Results of Ga-67 scanning in other regions were equivalent to those obtained by other diagnostic tests. Ga-67 citrate scanning thus offers an advantageous means of determining the exact stage of the disease and therefore its treatment.

Adolescent↗
PubMed1975

[Liver scanning in diffuse liver disease (author's transl)].

The results of liver scans performed with 99mTc-sulphur colloid in 169 patients suffering from diffuse liver diseases and in 48 normal controls were evaluated. The patients with reactive hepatitis, acute hepatitis, chronic persistent hepatitis, fatty liver and fibrosis of the liver show only minimal deviations from the scintigraphic pattern. On the contrary, highly increased colloid uptake in the spleen is found in cases of chronic aggressive hepatitis, whilst the intrahepatic distribution of the colloid is approximately normal. In cases of liver cirrhosis, increased colloid uptake is found in the left lobe of the liver as well as in the spleen and in the bone marrow. Either normal findings or cirrhosis-like changes of the colloid distribution are observed in patients with alcoholic hepatitis.

Bone Marrow↗
PubMed1975

[Autoimmune phenomena in D-penicillamine therapy].

In two patients with rheumatoid arthritis, immunoglobuline deposits in the skin were detected during D-penicillamine treatment. One patient presented with drug induced exanthema, the other with pemphigus erythematosus which was confirmed by clinical, histological, and immunofluorescent findings. During the development of the specific side-effect in one patient, an increase of ANA-titre and antibody-binding-capacity versus denaturated DNA was observed. Therefore in a prospective study of another ten patients during four months after onset of treatment with D-penicillamine, antinuclear antibodies and antibody-binding-capacity versus native and denaturated DNA were examined. The latter group of patients - without skin lesions - did not show any changes in the above mentioned parameters.

Antibodies, Antinuclear↗
PubMedDate not supplied

The efficacy and safety of fentiazac and diclofenac sodium in peri-arthritis of the shoulder: a multi-centre, double-blind comparison.

In a double-blind parallel group comparison of efficacy and safety, 19 patients with peri-arthritis of the shoulder received 200 mg fentiazac twice daily and 19 received 50 mg diclofenac sodium twice daily, with both drugs given orally for 3 weeks. In both groups, observers' verbal rating scales of pain severity at rest and on movement showed decreases that were significant by week 1. Both groups also had significant improvement in abduction, external rotation, retroversion and anteversion. At week 1, the patients reported improvement, on a verbal rating scale, of global effectiveness, but there were no subsequent changes. There were no statistically significant differences between the treatments in any of these variables. Five (26%) fentiazac-treated patients and four (21%) diclofenac sodium-treated patients reported adverse effects, mostly gastro-intestinal. One case of rash in each group and one case of pruritus in a diclofenac sodium-treated patient were severe enough for the patients to be withdrawn from therapy. There were no clinically significant changes in laboratory values. It was concluded that fentiazac (400 mg/day) and diclofenac sodium (100 mg/day) were equally effective within 1 week in decreasing pain severity and improving shoulder mobility.

Acetates↗
PubMedDate not supplied

[EA rosettes in patients with progressive chronic polyarthritis].

One subpopulation of human lymphocytes contains Fc-receptors that form rosettes with antibody (IgG) coated human erythrocytes (EA-rosettes). On the average 8.9% of the lymphocytes from patients with rheumatoid arthritis (RA) form EA-rosettes compared with 5.3% in controls. When the lymphocytes were washed three times the EA-rosettes increased to 21.2% for RA patients and 9.5% for controls. This procedure thus reveals more Fc-receptors on the lymphocytes from RA patients than on those from healthy controls. The number of T-lymphocytes was normal in RA patients and controls, no matter how many times the lymphocytes were washed.

Adult↗
PubMedDate not supplied

[Mixed connective tissue disease. Clinical studies on a new group of collagenoses].

The clinical features of 6 patients with symptoms of various connective tissue diseases and rheumatoid arthritis are reported. The frequency of symptoms corresponded to that of the syndrome, which Sharp et al. (1971) termed mixed connective tissue disease. The antibodies to an extractable nuclear antigen are a characteristic feature. Moreover, one may detect a speckled staining pattern by indirect immunofluorescence. In addition, moderate immunoglobulin deposits were observed in the skin and kidneys of our patients. The pathomechanism of these deposits is discussed.

Adult↗