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Biomedical subjects

O Segol

Publications and source records attributed to O Segol.

6 recordsLinked to original sources
PubMed1995

[Primary gastric tuberculosis].

Intestinal tuberculosis (TB) comprises 5% of all cases of TB and may be a major problem in immigrant communities, although the incidence of pulmonary TB is declining. Gastric TB is rare, constituting 0.1-2% of all cases of TB. Gastric TB usually develops secondary to other tuberculous lesions, most commonly pulmonary. On endoscopy antral infiltrative lesions are found. Primary gastric TB is very rare, only 8 cases having been reported in the English literature. We report a case of primary gastric TB in a 55-year-old woman who presented with abdominal pain and gastric outlet obstruction. The diagnosis was confirmed by endoscopic biopsies which showed granulomas, but no acid-fast bacilli. The Mantoux test was positive, acid-fast bacilli were found in the gastric juice, and a positive culture for TB was obtained on gastric lavage. There was an excellent response to antituberculous chemotherapy. With the relative rate of extra-pulmonary TB increasing, primary gastric TB should be taken into account in the differential diagnosis of infiltrative lesions of the antrum.

Antitubercular Agents↗
PubMed1987

Detection of antibodies to total histones and their subfractions in systemic lupus erythematosus patients and their asymptomatic relatives.

Sera drawn from 75 patients with systemic lupus erythematosus, 141 healthy relatives (from the families of 51 patients), and 115 healthy control subjects were examined, by enzyme-linked immunosorbent assay, for IgG and IgM antibodies to total histones and their subfractions. Compared with the controls, statistically significant numbers of patients and their relatives had antihistone antibodies of both isotypes. Among the relatives, the sera from females, notably sisters of the patients, contained the highest levels of anti-total histone antibody. Anti-H2A/H2B and H3 antibodies were most prevalent among the lupus patients, but many of the relatives had IgM anti-H4 antibodies. These findings indicate that antihistone antibodies can serve as a genetic marker in patients with systemic lupus erythematosus.

Autoantibodies↗
PubMedDate not supplied

Anti-histone antibodies in SLE and other autoimmune diseases.

The frequency of IgG and IgM anti-total histones and anti-histone subfractions were studied in 63 patients with SLE and 257 patients with other autoimmune conditions employing the ELISA. IgG anti-histone antibodies were found in 17 of 63 (25%) sera of lupus patients and in only 16 of 257 (6%) sera of patients with other autoimmune conditions. The latter incidence did not differ statistically from that of 115 healthy control subjects. Furthermore, the concomitant appearance of both IgG and IgM anti-histone antibodies was observed only in SLE patients. Anti-histone subfraction (H1, H2A, H2B, H3, H4) activity was determined in sera containing anti-total histone antibodies. There was a higher preponderance for antibodies to H1, H2A, H2B in SLE. We conclude that anti-histone antibodies seem to be a marker for lupus and its variants (e.g. drug induced lupus) and should be routinely looked for in SLE patients.

Antibodies↗
PubMedDate not supplied

Prevalence of markers of infection with hepatitis B and C viruses in immigrants of operation Solomon, 1991.

Sera of 200 recent Ethiopian immigrants (less than 1 year in Israel) were tested for the presence of antibodies against hepatitis B and hepatitis C viruses. The prevalence of the various markers was: anti-hepatitis B core antigen (anti-HBc) 52%, and hepatitis B surface antigen (HBsAg) 11.5%. None of the HBs-positive sera tested positive for IgM-anti core. Sixty-eight sera from nonvaccinated subjects were tested for anti-HBs, and 12 of them were anti-HBc negative/anti-HBs positive (the only positive marker was anti-HBs). Four of 23 HBsAg-positive sera were HBcAg positive (17%), and only 1 of 18 HBeAg-negative sera was positive for anti-e antibodies. Antibodies to hepatitis C were positive in 6/200 sera (3%).

Adolescent↗