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O Simonsen

Publications and source records attributed to O Simonsen.

At least 73 records · Page 4Linked to original sources
PubMed1985

Sarcoidosis with normocalcemic granulomatous nephritis. Five case reports and a review of 24 cases in the literature.

5 cases of sarcoidosis with normocalcemic granulomatous nephritis and renal impairment are described. 24 earlier reported cases with normocalcemic granulomatous nephritis of sarcoidosis were extracted from the literature and reviewed together with the present cases. GFR was normal (greater than 80 ml/min) in 2 of the patients, slightly to moderately decreased (80-20 ml/min) in 14 patients, and severely decreased (less than 20 ml/min) in 13 patients. The patients (19 males and 10 females) were 12-68 (median 45) years old. All patients with GFR less than 10 ml/min were more than 43 years old. 1 patient died in terminal uremia on admittance. All but 1 of the patients treated with corticosteroids improved (22 patients) or stabilized (5 patients) at least initially. 1 patient treated with a relatively low dose of a corticosteroid progressed to terminal uremia. 8 patients had a relapse when the corticosteroids were tapered or discontinued. 12 of the patients had residual renal impairment after initial successful treatment and in 4 cases the impairment worsened after a corticosteroid-sensitive relapse. It could be concluded from the study that an initial corticosteroid dosage of 1 mg prednisolone/kg BW or more should be used in granulomatous nephritis of sarcoidosis.

Aged↗
PubMed1985

The blood serum concentration of cystatin C (gamma-trace) as a measure of the glomerular filtration rate.

The blood serum concentrations of creatinine and the low molecular weight proteins cystatin C, beta 2-microglobulin and retinol-binding protein were measured in 106 patients whose glomerular filtration rates were assessed by Cr-ethylenediaminetetraacetate (EDTA)-clearance determinations. The reciprocals of the serum concentrations of creatinine, cystatin C and beta 2-microglobulin were closely correlated to the Cr-EDTA-clearance (r = 0.73, 0.75 and 0.70, respectively) in contrast to the corresponding values for retinol-binding protein (r = 0.39). The calculated values of the glomerular elimination rate for creatinine and cystatin C were normally distributed in contrast to those for beta 2-microglobulin. The calculated glomerular elimination rate of cystatin C was not correlated to age, sex, type of disorder or disease activity. The results demonstrate that the serum level of cystatin C is a better measure of the glomerular filtration rate than the serum level of beta 2-microglobulin.

Adolescent↗
PubMed1985

Prevention of postoperative deep venous thrombosis. Low-dose heparin versus graded pressure stockings.

In a prospective, controlled clinical study prevention of postoperative deep venous thrombosis by low-dose heparin (Heparin Leo 5 000 I.U. subcutaneously twice daily) was compared with graded compression stockings (TED stockings, Kendall Co.). One hundred and twelve patients, admitted during a period of one year for elective major surgery, were allocated to one of the two treatment groups. In order to detect deep venous thrombosis the 99mTc-plasmin test was performed before the operative procedure and again 5 days later. Ninety-seven patients completed the study (45 patients in the heparin group and 52 patients in the stocking group). Venous thromboembolism was detected in 4 patients (8.9%) in the heparin group and in 3 patients (5.8%) in the stocking group (p greater than 0.05). In 6 patients the plasmin test was positive and one patient in the heparin group died following pulmonary embolism. It is concluded that graded compression stockings can be used as an alternative to low-dose heparin for prophylaxis against deep venous thrombosis in elective general surgery.

Adult↗
PubMed1984

Immunity against tetanus and effect of revaccination 25-30 years after primary vaccination.

Fall off in tetanus immunity and the effect of late revaccination were investigated in a randomly selected group of Danes aged 25-30. Routine reinforcing doses of tetanus toxoid are not customary in Denmark except at injury and when there are certain occupational risks. 11% of the total group of 418 had antitoxin titres below that required for protection (ie, less than 0.01 IU/ml, determined by neutralisation technique). In those who had received only primary vaccination an exponential fall off in immunity was seen, and 25-30 years after primary vaccination, 28% had serum antitoxin concentrations below the level of protection. Up to 30 years after primary vaccination, one reinforcing dose of tetanus toxoid adsorbed by aluminium hydroxide was sufficient to induce protective titres of antitoxin. There were no serious side-effects and it was concluded that routine reinforcing doses of tetanus toxoid should be given before the age of 20 in Denmark and other countries where primary vaccination is given in the first years of life.

Adult↗
PubMed1984

Displaced forearm fractures in children treated with AO plates.

Internal fixation with AO compression plates was carried out in 8 per cent of all children with displaced diaphyseal fractures of the forearm. Primary treatment for 23 of these 43 fractures consisted of primary fixation. All fractures healed in anatomical alignment. Deep infection was observed in 1 child. All fractures united but 1 refractured . Of 29 children, 27 were reexamined after a mean observation time of 5 years; 22 had obtained normal function of the arm, and nobody had restriction of rotation of the forearm exceeding 20 degrees. The mean overgrowth of the bones was 2.4 mm. Fifty-six per cent of the children had discrepancies in the linear growth between the radius and the ulna in the fractured arms. These disturbances had no influence on the functional results. We conclude that internal fixation with AO plates is preferable when closed reduction fails or when secondary displacement cannot be corrected by repeated gentle manipulation.

Adolescent↗
PubMed1984

The accuracy of clinical examination of injury of the knee joint.

This study is an analysis of the clinical examination of 118 consecutive patients with severe, acute injury of the knee joint, that is, with intra-articular effusion or with clinical suspicion of ligamentous instability. Both the clinical examination and the examination under anaesthesia for ligamentous instability involve a large number of falsely positive and falsely negative diagnoses. The greatest uncertainty is attached to the examination of the anterior cruciate ligament and menisci. The diagnostic specificity and the diagnostic sensitivity of the clinical examination of the anterior cruciate ligament are 0.75 and 0.62 respectively. The corresponding values for examinations under anaesthesia are 0.86 and 0.76 respectively. Two-thirds of the patients without intra-articular effusion, whose clinical examination gives rise to suspicion of ligamentous instability, however, have subclinical intra-articular haemorrhage and have as many cruciate and combined lesions as the whole series, viz. respectively 63 and 47 per cent. On the basis of this we conclude that arthroscopy should be carried out in all patients with a traumatic haemarthrosis or indication of ligamentous instability.

Adolescent↗
PubMed1984

Heparin-induced increase in serum levels of aminotranferases. A controlled clinical trial.

Sixty-four patients over the age of 40 years, undergoing elective surgery of at least one hour's duration, were randomized to treatment with either a thromboembolic deterrent ( TED ) stocking (Kendall Co.) or subcutaneous low-dose heparin 5 000 IU every 12 hours. Serum levels of alanine aminotransferase (S-ALAT), aspartate aminotransferase (S-ASAT), gamma-glutamyl transpeptidase (S-gamma-GT) and alkaline phosphatase (S-ALP) were measured. S-ALAT increased significantly on the 5th and 10th postoperative day, from 27 +/- 2 (x +/- SE) to 40 +/- 4 (p less than 0.01) and 55 +/- 7 U/l (p less than 0.001), respectively, in the heparin group and was significantly higher in the heparin than in the TED group both on the 5th (p less than 0.01) and 10th (p less than 0.05) postoperative day. S-ASAT and S-gamma-GT increased significantly during heparin treatment, but did not differ significantly from the values of the TED group. No change in S-ALP was registered in either group. It is concluded that prophylactic treatment with low-dose heparin induces a significant increase in S-aminotransferase levels, especially in S-ALAT. The phenomenon has profound differential diagnostic implications in conditions such as pulmonary embolism and acute myocardial infarction.

Adult↗
PubMedDate not supplied

Volvulus of the sigmoid colon in Brazil: a report of 230 cases.

Etiologic and physiopathologic aspects of volvulus of the sigmoid colon in Brazil are presented. It is believed that sigmoidal volvulus in Brazil is a frequent complication of megacolon caused by Chagas' disease, differing in some characteristics from volvulus found in other countries. A review of 230 cases treated between 1938 and 1974 in the Surgical Department of Hospital das Clinicas, University of Sao Paulo School of Medicine, is presented. The successive variations used to treat this disease occurred parallel to those introduced in the surgical treatment of uncomplicated megacolon. From the results, the following treatment is recommended: endoscopic emptying in cases without clinical, roentgenographic or endoscopic signs of intestinal ischemia. Laparotomy should be performed when a complicated volvulus is suspected or when it is not possible to empty the loop. When a simple volvulus is found, the loop should be untwisted and the gaseous contents siphoned off by menas of a rectal catheter. When there is necrosis of the colon, the Hartmann operation is recommended. It is important to submit patients to a definitive treatment of the megacolon soon after endoscopic emptying or surgical detorsion of the volvulus, since recurrences following these measures are frequent.

Adult↗
PubMedDate not supplied

Altered timing of hamstring muscle action in anterior cruciate ligament deficient patients.

Recent studies indicate that the hamstrings are essential antagonists in ACL deficient patients. In order to evaluate muscle coordination under physiologic conditions, nine patients with arthroscopically verified total ACL ruptures were compared with nine control volunteers. This comparison was made from electromyograms of the thigh muscles and heel contact recordings made while walking on a treadmill. While walking on a horizontal level, the patient's muscle activity did not differ from controls, but when the knee load was increased by walking uphill, the hamstring muscles in patients were activated significantly earlier than among controls. It is proposed that an altered muscle coordination is probably essential in ACL deficient patients to secure knee stability. This study suggests a new approach to investigate the coordination of muscles under physiologic conditions in ACL deficient patients, and may guide rehabilitation programs in the future.

Adult↗