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O Suhonen

Publications and source records attributed to O Suhonen.

12 recordsLinked to original sources
PubMed1988

Risk factors for sudden and non-sudden coronary death.

The impact of risk factors for sudden and non-sudden coronary death was investigated in 3,589 Finnish men aged 40-59 years at entry from a prospective population survey. During a mean follow-up time of 11 years, 234 coronary deaths occurred, 150 of which were sudden, i.e. ensuing within 1 hour of the onset of symptoms. The severity of the manifestations of CHD at baseline investigation appeared to be a powerful predictor of sudden coronary death. Smoking and high serum cholesterol were significant predictors of sudden coronary death. High serum cholesterol was an equally significant predictor of sudden and non-sudden coronary death. High blood pressure did not appear to significantly increase sudden coronary death but increased the incidence of non-sudden death significantly. Obesity and diabetes did not appear to be independent risk factors for sudden coronary death. Smoking and high serum cholesterol were significant risk factors for sudden coronary death in men with manifestations of coronary heart disease. The results suggest that reduction of primary risk factors, especially smoking and high serum cholesterol, is important even after coronary heart disease has become manifest.

Adult↗
PubMed1987

Alcohol consumption and sudden coronary death in middle-aged Finnish men.

The association between consumption of alcoholic beverages (spirits, beer and wine) and coronary heart disease (CHD) mortality, especially the incidence of sudden coronary death (SCD), was investigated in a 5-year prospective population study comprising 4,532 men aged 40-64 years. The amount of alcohol used was estimated on the basis of answers to a self-filled structured questionnaire. The incidence of SCD was statistically significantly lower among abstainers than among alcohol consumers. The relative risk of SCD of alcohol consumers in comparison with abstainers was largest in the oldest age group and it became more apparent after a follow-up of a couple of years. Only the consumption of spirits was positively associated with the incidence of SCD. Among non-smokers the incidence of SCD was statistically significantly higher in consumers than in abstainers, a similar but not significant trend was observed among current smokers. The positive association between alcohol consumption and incidence of SCD was detected both in CHD-free men and in men with prior CHD. Consumption of alcoholic beverages, and in particular of spirits, is associated with an increased risk of SCD in Finnish men.

Adult↗
PubMed1985

Four-year incidence of myocardial infarction and sudden coronary death in twelve Finnish population cohorts.

The incidence of myocardial infarction (MI) and sudden coronary death in four years was studied in 6510 men and 5800 women, aged 30-59 years, derived from 12 Finnish population cohorts constituting the invited population to a prospective study. The incidence of all fatal coronary events in four years was 13.0/1 000 in men and 1.8/1 000 in women. The incidence of sudden coronary death was 7.8/1 000 in men and 0.7/1 000 in women. The incidence of non-fatal MI was 22.2/1 000 in men and 7.3/1 000 in women. Coronary mortality was significantly higher in non-participants in the initial survey than in participants. The incidence of MI was highest in men from eastern Finland (North Karelia), intermediate in men from central and western Finland and lowest in men from southwestern Finland. There were no significant regional differences in the incidence of MI in women. The incidence of MI in this study was in good agreement with that recorded in the myocardial community registers.

Adult↗
PubMed1985

Incidence of different manifestations of coronary heart disease in middle-aged Finnish men and women.

The incidence of myocardial infarction and symptoms of coronary heart disease (CHD) were investigated in a prospective Finnish population study. Drawn from four geographical areas in Finland the study population comprised 5 438 men and 4 924 women aged 30-59 at entry. The results are based on a re-examination of the study population after a mean follow-up time of six years. The average annual incidence of coronary death was 3.8/1 000, and that of non-fatal infarction 6.5/1 000 in men and 0.4/1 000 and 2.1/1 000 in women. Ten per cent of all infarctions were silent, revealed only by ECG changes. Cases of new angina pectoris comprised 40% of all the new events in men but 80% in women. This descriptive report serves as the basis for subsequent analyses comprising risk factors for different CHD manifestations.

Adult↗
PubMed1984

Validity of hospital discharge data in a prospective epidemiological study on stroke and myocardial infarction.

The validity and coverage of hospital records of stroke and myocardial infarction were evaluated in a Finnish epidemiological cohort consisting of 57000 men and women. Information on their hospitalizations after the baseline examination was obtained by record linkage to the National Hospital Discharge Register. As compared to data based on re-examination of survivors after five years, the discharge register covered 78.2% of hospital treatments. A specific diagnosis code had been recorded for 81.7% of the definite strokes and for 84.7% of the definite myocardial infarctions. The 5-year incidence rates based on both hospital records and deaths were clearly lower than the rates previously reported from local registers of stroke and myocardial infarction in Finland. Although hospital discharge information underestimates morbidity in the population, the data are sufficiently valid for many epidemiological purposes, e.g. research on predictors of diseases.

Adolescent↗
PubMed1983

Sudden coronary death in middle age and characteristics of its victims in Finland. A prospective population study.

A total of 77 sudden coronary deaths (SCD) in men and seven in women occurred during a 6-year follow-up in a population comprising 6510 men and 5800 women aged 30-59 years in four areas of Finland. About 60% of all coronary deaths in men aged 40 and over were SCDs. The most common place of death was home; only six cases reached hospital. The most common time for SCD was at 7 a.m.-3 p.m. and the most common day was Friday. Deaths were evenly distributed over the year. At the time of the baseline study--3 1/2 years before death on an average--male SCD victims showed more symptoms and signs suggestive of coronary disease than those who suffered a non-sudden coronary death or a non-fatal myocardial infarction. More than half of the SCD victims had probable coronary disease at the time of the baseline study. Heart disease was a more common cause of death among the mothers of male SCD victims than among the adult Finnish female population as a whole. This study indicates that the majority of candidates for later SCD can be detected early enough for secondary prevention to be attempted.

Adult↗
PubMed1978

Diclofenac sodium (Voltaren) and indomethacin in the ambulatory treatment of rheumatoid arthritis: a double-blind multicentre study.

In a double-blind crossover trial conducted on a multicentre basis, 109 patients with "classic" or "definite" rheumatoid arthritis were treated for two weeks with diclofenac sodium (Voltaren, 25 mg t.i.d.) and indomethacin (25 mg t.i.d). Both drugs led to a clear-cut decrease in morning stiffness, as well as to a significant improvement in pain at rest and on movement. In these respects no significant difference between the two-drugs was observed. As regards their effect on status of rheumatoid condition, however, a trend towards a significant improvement was discernible, in the investigator's opinion, only in response to diclofenac sodium. "Unwanted effects" were mentioned by 25 patients before the trial, by 31 during treatment with diclofenac sodium, and by 33 during treatment with indomethacin. While the patients were receiving indomethacin, five of them discontinued treatment on account of side effects (headache in three cases, headache and tiredness in one case, and an allergic skin reaction in one case) and one of them, who complained of headache, lowered the dosage; treatment with diclofenac sodium was discontinued because of side effects by only one patient, who had developed an allergic skin reaction.

Adult↗