PubMed Health⌕ Search

Biomedical subjects

O Thulesius

Publications and source records attributed to O Thulesius.

At least 19 recordsLinked to original sources
PubMed1978

Physiological and pharmacological studies on isolated human bronchial preparations.

The contractile response of human bronchial smooth muscle preparations obtained after death (necrobronchi) from 15 patients was studied in vitro. Reproduceable responses sufficient for calculating dose-response curves, could be obtained up to 30 h after death. A number of smooth muscle stimulants were investigated: 1) carbacholine, 2) acetylcholine, 3) histamine and 4) electrical field stimulation. In addition to these bronchial smooth muscle relaxants such as adrenaline, salbutamol and terbutaline were also studied. These agents showed a dose-dependent relaxation in preparations previously treated with carbacholine. It can be concluded that in vitro testing of smooth muscle preparations obtained from human cadavers is possible.

Acetylcholine↗
PubMed1976

Effect of nicotine on isolated human blood vessels.

The action of nicotine was studied in isolated human vascular strip preparations using isometric recording of tension. Nicotine per se did not elicit any significant changes of smooth muscle tone. The effect of noradrenaline and direct smooth muscle stimulation, however, was enhanced. This action presumably is not dependent upon an adrenergic nervous mechanism, as in the intact organism but seems to be dependent upon a direct smooth muscle stimulation in itself not sufficiently strong to induce a contraction but leading to facilitated stimulation and propagation of the response.

Adolescent↗
PubMed1975

Pressure-volume characteristics of foot veins in normal cases and patients with venous insufficiency.

In order to evaluate pressure-volume characteristics of foot veins in patients with venous insufficiency compared with a control group, the foot-volumetric method was utilized, combined with intravenous pressure measurements. Calculations of compliance and elastance were preformed within a fixed pressure interval, where the veins were filled or almost filled. The investigation demonstrates a lower compliance and a higher elastance in the varicose veins compared with the control cases. This is contrary to most previous investigations, in which the veins have not been fully distended, as the measurements were preformed in the lying position with rather low venous pressure. Changes of compliance and elastance were most marked in cases with advanced venous disease and skin changes of the ankle region. The observed changes of a 'greater stiffness' of the foot-vascular system can be explained by fibrotic or phlebosclerotic changes. In addition to the observations of slightly altered elasticity factors, we observed volume changes after exercise which seem to be related to capillary filtration.

Adult↗