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Biomedical subjects

O Topolcan

Publications and source records attributed to O Topolcan.

At least 55 records · Page 3Linked to original sources
PubMed1991

[The significance of myoglobin determination in the differential diagnosis of chest pain syndrome].

In 1984-88 the authors examined in 813 subjects with the chest pain syndrome of varying aetiology (acute myocardial infarction, myocarditis, pericarditis, vertebrogenic algic syndrome, embolism of the pulmonary artery, patients lacking detectable organic causes of pain) the trend of myoglobin serum levels. They found significantly elevated values only in patients with myocardial infarction and myocarditis whereby the two diseases differ in particular as regards the shape of the curve of myoglobin values. In chest pain with another aetiology the myoglobin levels rose only rarely or not at all. From the differential diagnostic aspect it is particularly valuable that myoglobin was not elevated in any patient with embolism of the pulmonary artery and only very rarely in angina pectoris. Where in exceptional instances the myoglobin levels were elevated in patients with other investigated causes of chest pain, this increase was always due to another basic disease (right-sided cardiac failure, renal insufficiency, neuromuscular disease), whereby for these conditions prolonged persistence of the elevated serum myoglobin values was typical and the levels were never above 8 nmol/l.

Chest Pain↗
PubMed1989

[Pharmacologic restoration of sinus rhythm in atrial flutter and fibrillation].

Restoration of the sinus rhythm in atrial fibrillation and flutter can be achieved by cardioversion, using an electric discharge, or by medicamentous treatment. Medicamentous treatment is based above all on a combination of antiarrhythmic drugs. By the concurrent administration of quinidine, verapamil and digoxin restoration of the sinus rhythm is achieved in 80% patients, on average after 37 hours at plasma quinidine levels of 2.57 +/- 1.4 (SD) micrograms/ml and digoxin levels of 1.90 +/- 1.3 (SD) nmol/l. Restoration of the sinus rhythm in atrial flutter calls for higher quinidine and digoxin levels than in atrial fibrillation (p less than 0.01). Prolonged persistence of the sinus rhythm during treatment with maintenance doses of quinidine, verapamil and digoxin is not satisfactory so far and after 12 months the sinus rhythm persists only in 30% of the patients where the rhythm was originally restored.

Atrial Fibrillation↗
PubMed1988

Cross-sectional study of beer consumption and blood pressure in middle-aged men.

Alcohol consumption in the week prior to examination was assessed in 352 men (average age 52.5 years) selected randomly from a cohort of employees of an industrial plant. Men drinking more than 350 g ethanol per week, largely in the form of a local beer, did not differ in respect of BP but they smoked more cigarettes and had lower serum magnesium levels and immunoreactive insulin levels than the rest of the sample. In a multiple linear (step-wise) regression analysis, body mass index, age, immunoreactive insulin two hours after glucose load and serum total cholesterol contributed directly to the BP value but the weekly ethanol intake did not. Smoking contributed negatively to the BP value after an a priori exclusion of total cholesterol, HDL cholesterol, magnesium and results of glucose tolerance tests. Only immunoreactive insulin and age were related significantly to ethanol consumption. No significant association of alcohol consumption with BP was found.

Age Factors↗
PubMed1985

[Parathyroid glands in long-term dialysis].

Parathyroid glands from 100 deceased persons treated by hemodialysis were compared with 84 bone lesions and with immunoreactive parathormon in serum of 59 cases. Parathyroid findings were in correlation with the type of bone lesion and parathormon rates. Increase of parathormon in hemodialysed patients reflected the hyperplasia of parathyroid glands.

Bone Diseases↗