Biomedical subjects

O Ukimura

Publications and source records attributed to O Ukimura.

42 records · Page 3Linked to original sources

PubMed1994

Percutaneous biopsy for adrenal tumors using ultrasonically guided puncture.

Percutaneous biopsy for adrenal tumors was performed on 12 patients using ultrasonically guided puncture. Of the 12 tumors, 11 were detected incidentally by ultrasonography or computed tomography. In 11 cases, cytological or pathological diagnosis was obtained without any complication. Among these, surgical operation was carried out in 4 cases, in which biopsy findings were confirmed by the examination of the surgical specimens. The other 7 cases were being followed up without surgery. The rate of correct discrimination between benign and malignant adrenal tumors by biopsy was 91% (10/11 cases) in this series. It is accordingly considered that adrenal biopsy is the choice to confirm the diagnosis of nonfunctioning adrenal tumors because of its efficacy and ease of use.

Adrenal Gland Neoplasms↗

PubMed1994

[A case of malignant pheochromocytoma treated with 131I-metaiodobenzylguanidine and CVD regimen].

A 44-year-old male had multiple metastasis to the lung, liver, kidney and paraaortic lymph node from primary adrenal malignant pheochromocytoma. Radiation therapy with 131I-metaiodobenzylguanidine (131I-MIBG), was first performed, which was followed by chemotherapy with cyclophosphamide, vincristine and dacarbazine (CVD). A total amount of 4810 MBq of 131I-MIBG was administered then 7 cycles of CVD regimen were added. He was survived for sixteen months with tumor response in primary tumor, paraaortic lymph node and liver metastasis tumors, in addition to hormonal response. It was considered that the survival was prolonged in spite of advanced case with inoperative primary tumor.

3-Iodobenzylguanidine↗

PubMed1994

[Endoscopic adrenalectomy by retroperitoneal approach for primary aldosteronism].

Endoscopic adrenalectomy by a retroperitoneal approach through the skin incision less than 5 cm has been performed in 6 patients (3 males and 3 females; 4 right and 2 left side) with primary aldosteronism from December 1992 to June 1993. The treatment was successful in all the cases. As for complications, pneumothorax occurred in one case. The required operation time was from 120 to 330 min (mean: 196 min) and the blood loss was from 20 to 279 ml (mean: 94 ml), which were similar to those in open adrenalectomy. The retroperitoneal approach was thought to be more advantageous than widely adopted laparoscopic adrenalectomy in the following points: (1) No complications such as pulmonary embolism or pneumomediastinum. (2) No injuries to the intraabdominal organs. (3) Two operators using one video system is sufficient.

Adenoma↗

PubMed1993

Effects of intravesically administered anticholinergics, beta-adrenergic stimulant and alpha-adrenergic blocker on bladder function in unanesthetized rats.

Comparative analysis of the effects of intravesical instillation of drugs on urodynamic parameters (MVP, maximum intravesical pressure; RR, residual rate; BC, bladder capacity) was performed using an experimental model in unanesthetized rats. The drugs investigated in this study were atropine (7.2 x 10(-4)-7.2 x 10(-2) M), propantheline (7.2 x 10(-3)-2.2 x 10(-2) M), oxybutynin (2.5 x 10(-3)-2.5 x 10(-2) M), isoproterenol (5 x 10(-2)-10(-1) M) and prazosin (5 x 10(-4) M). Of the anticholinergics, propantheline and oxybutynin showed a remarkable suppression of MVP accompanied with a consistent increase of RR and BC in a dose-dependent manner. Atropine showed, however, no suppression of MVP in spite of a significant change of RR and BC. Isoproterenol suppressed MVP with an increase of RR and BC in a dose-dependent manner at a relatively high concentration. Prazosin increased BC and RR at a relatively low concentration. This study revealed that these intravesical drugs have the ability to suppress spontaneous bladder contraction in unanesthetized rats and to change the micturition function in the urinary filling and storage phases. It is expected that intravesical instillation therapy for detrusor hyperreflexia will be improved in the future based upon the data obtained.

Administration, Intravesical↗

PubMed1992

Effects of intravesically administered verapamil HC1 (calcium entry blocker) on the bladder function in unanesthetized rats.

The effects of intravesically administered verapamil HCl (calcium entry blocker) on the bladder function were investigated using an experimental model for unanesthetized rats. Intravesical verapamil HCl caused a marked suppression of maximum intravesical pressure accompanied by an increase of residual urine in a dose-dependent manner. The effect almost disappeared 90 min after the elimination of verapamil HCl. It is tentatively suggested that the intravesical instillation of verapamil HCl could be a potent therapy for disorders of bladder function, such as uninhibited contraction.

Administration, Intravesical↗

PubMed1992

[A clinical evaluation on postprostatectomy incontinence].

Postprostatectomy incontinence was evaluated in 193 patients, who underwent retropubic prostatectomy (RPP) or transurethral resection of the prostate (TURP) during the past 5 years from 1985 to 1989 at the Kyoto Prefectural University of Medicine. The occurrence rate of postprostatectomy incontinence was 17.2% in the patients who had undergone RPP and 33.3% of those who had undergone TURP. Although postprostatectomy incontinence disappeared within one week in half of the patients, postprostatectomy incontinence remained for more than one month in 4.9% of the patients who had undergone RPP and 3.3% of those who had undergone TURP. The incidence of postprostatectomy incontinence tended to be high in the patients of advanced ages. Postprostatectomy incontinence recognized in this series was classified into stress incontinence and urgency incontinence groups. An analysis of the results of cystometry performed before the operation showed that the volume of maximum desire of voiding in the urgency incontinence group was smaller than that in the group without postprostatectomy incontinence. Furthermore, supposing the urgency degree as a new parameter, which is defined as a ratio of first desire of voiding to maximum desire of voiding, the urgency degree of the urgency incontinence group was higher than that of the group without postprostatectomy incontinence. Patients with an urgency degree higher than 70% were found to have a high probability of urgency incontinence. These findings suggested that advanced age was the risk factor of postprostatectomy incontinence and that a small bladder capacity and high urgency degree were the high risk factors of postprostatectomy urgency incontinence.

Aged↗