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Biomedical subjects

O V Bukharin

Publications and source records attributed to O V Bukharin.

6 recordsLinked to original sources
PubMed1979

[Activation of student cognitive activities in the process of teaching medical microbiology].

The main trends of methodical work conducted at the chair of microbiology of Orenburng Medical Institute are presented. For the purpose of activation of cognition activity of students during medical microbiology teaching the following methods were applied: presentation of the teaching material, creation of visual teaching methods in a single methodical plan in accordance with the logic structure graphs of the subject as a whole, its individual sections and themes; introduction of problem teaching method, solution of practical tasks of the II and III learning level; introduction of scientific achievements of the chair into the teaching process. Result of evaluation of the efficacy of the teaching-methodical work of the chair carried out demonstrated that knowledge of the principal microbiology problems in the students and interns persisted for long periods of time.

Cognition↗
PubMed1978

[Lysozyme activity of pneumococci].

Examination of 329 pneumococcal strains showed that 41.2 per cent of the cultures had lysozyme activity. The frequency of the lysozyme feature depended on the method used. The lysozyme active strains were more frequently isolated from patients than from healthy persons and characterized by antibiotic resistance. The lysozyme feature correlated with the pneumococcal virulence with respect to albino mice, capacity for capsule formaiton and resistance to phagocytosis.

Animals↗
PubMed1978

[Experimental study of the antimicrobial effect of lysozyme in combination with antibiotics].

A synergistic effect of the antibacterial action of the lysozyme combination with various antibiotics against gram-positive and gram-negative microorganisms was found. The intensifying effect of lysozyme on its combination with antibiotics was more evident with respect to gram-positive microbes and less evident with respect to gram-negative organisms. The combinations os lysozyme with methicillin, lincomycin, oleandomycin or erythromycin proved to be most active against staphylococci. A high synergistic effect against streptococci was observed with the use of the lysozyme combination with benzylpenicillin, morphocycline, oleandomycin, ceporin or monomycin. The combination of lysozyme with macrolides had a maximum inhibitory effect on Coli bacteria.

Anti-Bacterial Agents↗
PubMed1976

[Characteristics of the antimicrobial activity of lysozyme].

The antibacterial effect of lysozyme manufactured in the USSR was studied with respect to 1496 pathogenic strains of different microbial species. It was found that the percentage of the organisms sensitive to lysozyme among the total number of the microbes tested was not high and ranged within 1.5-3 except streptococci (21.7 per cent). Significant differences in the minimum bacteriostatic concentration (from 0.0006 to 10 mg/ml) with respect to both different microbial species and organisms belonging to the same microbial species were found. By the level of the antibacterial activity the Soviet lysozyme was not inferior to the Italian preparation. With respect to streptococci the Soviet lysozyme was more active.

Bacteria↗