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Biomedical subjects

O V Mironova

Publications and source records attributed to O V Mironova.

13 recordsLinked to original sources
PubMed1993

[The effect of ultraviolet-irradiated blood on the factors determining an unfavorable prognosis in patients with progressive stenocardia].

Effect of autohemotransfusions of ultraviolet-irradiated blood (UVIB) on ventricular arrhythmias and electric stability of myocardium were studied in 85 patients with advancing stenocardia. Bicycle ergometry [correction of Veloergometry], Holter's monitoring and invasive programmed cardiostimulation were used. Results of examination carried out before and after the treatment suggest anti-ischemic effect of PVIB and beneficial influence electrophysiological properties of myocardium which manifested in reduced periods of ventricular tachycardia and onsets of twin extrasystoles.

Adult↗
PubMed1992

[Changes in the parameters of the central and regional hemodynamics in patients with unstable stenocardia treated by the methods of quantum hemotherapy].

A study of 116 patients with nonstable stenocardia (age of the patients: 29-68 years). In 54 of them laser irradiation of the blood (LIB) was used, in 62--autorheography revealed a selective character of influence of LIB and ATIB on the hemo-hemotransfusion of irradiated blood (ACIB) and 32 received only drugs. Tetrapolar dynamics: tendency to averaging of the cardiac ejection. In patients with initially low values--an increase and with initially high values--a reduction. Possibly, this reaction has a nonspecific character and reflects the reaction of circulation to stabilization of the patients' condition. The hemodynamic parameters did not deteriorate below critical levels. Hence, these methods may be used in patients with nonstable stenocardia associated with initial disorders of the central and peripheral hemodynamics.

Adult↗
PubMed1991

[The effect of a limited area of infarction on the course of ischemic heart disease in patients with a history of myocardial infarct].

Results are described on the effect of limitation of the infarction zone on the course of IHD during the first year of observation in 320 patients with a history of myocardial infarction (MI). The clinical course of the disease and changes of tolerance of physical load were studied in two groups of patients. In one of the groups limitation of the infarction zone was realized during the first ten days. It was found that limitation of the infarction zone is of importance only in the acute period of MI reducing the frequency of fibrillations and lethal outcomes. Limitation of the infarction zone did not effect the course of IHD during the first postinfarction period. Infarction in the involved zone showed no increases in frequency.

Coronary Disease↗
PubMed1990

[Effect of labetalol on hemodynamics and oxygen consumption in patients in the early period of myocardial infarction].

Effects produced both by single intravenous drop-by-drop labetalol, 1 mg/kg (29 patients), sublingual obsidan, 20 mg (14 patients) and a 3-day course treatment with labetalol, 200-600 mg/day, and obsidan (80-160 mg/day) on systemic, intracardiac, and regional hemodynamics and oxygen supply of the body were comparatively studied in 43 patients in early periods of myocardial infarction. As compared with obsidan, labetalol caused favourable hemodynamic changes mostly pronounced in patients with concurrent arterial hypertension. The hemodynamic effects in arterial hypertension were found to come about by virtue of largely an alpha-adrenoblocking effect of the agent whereas in the absence of hypertension it was beneficial due to a combined alpha- and beta-adrenoblocking effect.

Administration, Oral↗
PubMed1989

[Effects of opioids on the development of preimplantation mouse embryos].

Opioid peptide DAGO, agonist of opiate mu-receptors and naloxone antagonist of mu-, delta- and kappa-receptors in concentration 3 x 10 M inhibit embryonic development of CBA mice. Inhibition was stage-specific with maximal effect after addition of opioids to zygotes: in the presence of Naloxone no more than 6.7% of embryos reached morula and blastula stages and in the presence of DAGO--36.8%. The other embryos were arrested at two-, four- or, sometimes even, at eight-cell stages without any signs of fragmentation. Four and eight-cell embryos were less sensitive to drug action. Inhibitory effects of these opioids were reduced when they were added simultaneously to zygotes. Agonist of opiate delta-receptors, opioid peptide DADLe, failed to affect embryonic development.

Animals↗
PubMed1975

The effect of the splotch gene on the parameters of the cell cycle in the brain and spinal cord of mouse embryos.

The parameters of the cell cycle were determined in 10-day-old mouse embryos, homozygous for the splotch (Sp) gene, by the radioautographic method with H-3-thymidine. Normal embryos (+/+)with a similar genetic environment were used as the control. In the brain and spinal cord of Sp/Sp embryos the mitotic indices were more than twice as high as those in +/+ embryos. The rate of cell proliferation increased identically in both the dorsal and ventral parts of the neural tube. The generation time of the brain and spinal cord cells of Sp/Sp embryos was 8 h and that of normal embryos 9 h. The Sp gene decreased the duration of the S phase 1.5 h (25 percent). In addition, this gene increased the duration of the G(1) phase 0.5 h. The Sp gene evidently acts in the G(1) phase, as a result of which the duration of this phase increases while that of the S phase decreases considerably. This leads to an increase in the rate of cell proliferation and to the development of abnormalities of the CNS of homozygous embryos.

Animals↗
PubMed1975

[Analysis of the effect of the loop-tail gene in mouse embryos].

Mitotic index and parameters of the cell cycle were determined in the brain and spinal cord of 10 days old Lp/Lp and +/+ mouse embryos. The mitotic index and duration of the cell cycle periods proved to be the same for embryos of both the genotypes. The generation time of the brain and spinal cord cells both in the mutant and normal embryos is 9 hrs, durations of S- and G2-periods 6 and 1, resp., and the total duration of G1- and M-periods 2. The gene Lp does not interact with the gene Sp in double heterozygotes. The gene Lp does not manifest itself in the cells of differentiating central nervous system and the failure of the neural tube closure is not due to the changes in the proliferative activity of its cells and is a secondary gene effect.

Animals↗
PubMedDate not supplied

[An analysis of parthogenetic cell clones in chimeric C57BL/6(PG)<-->BALB/c mice].

We studied the distribution of parthenogenetic cell clones in the retinal pigment epithelium and choroid of eyes on serial sections and in the brain, kidneys, and liver by electrophoretic analysis of glucose phosphate isomerase isozymes in 12 mouse chimeras C57BL/6(PG)<-->BALB/c obtained earlier. Asymmetry was noted in the distribution of the parthenogenetic cell clones in the eye structure, just as the earlier established asymmetry in the distribution of the parthenogenetic clones of epidermal melanoblasts. A high correlation was shown between the ratio of parthenogenetic to normal cells in the retinal pigment epithelium of the right or left eyes and epidermal melanoblasts in the hair cover of the corresponding body half of the chimera. These data suggest that there is a certain relationship between the processes leading to the characteristic distribution of the ectodermal parthenogenetic clones in the retinal pigment epithelium of the right and left eyes and epidermal melanoblasts in parthenogenetic chimeras. Electrophoretic analysis did not show parthenogenetic components in the liver or kidneys of any chimera, and the parthenogenetic component was found in the brain of only two chimeras, in which a high percentage of parthenogenetic cells of ectodermal origin was noted. In these cases, asymmetry was noted in the right and left cerebral hemispheres, just as in the retinal pigment epithelium of the right and left eyes. The data obtained suggest that, during the development of the chimeras, parthenogenetic C57BL/6 cells were actively eliminated from the tissues of endodermal and mesodermal origin. In adult chimeras C57BL/6(PG)<-->BALB/c, parthenogenetic cell clones of ectodermal origin are mostly preserved.

Animals↗
PubMedDate not supplied

[Effects of growth factors FGF4, TGFalpha, and TGFbeta1 on the development of parthenogenetic embryos of C57BL/6 mice].

We studied the effects of three growth factors, fibroblast growth factor (FGF4), transforming growth factor alpha (TGFalpha), and transforming growth factor beta1 (TGFbeta1), on development of diploid parthenogenetic embryos of C57BL/6 mice, which are not capable of developing to somatic stages. Parthenogenetic embryos were treated with growth factors at optimal doses in vitro at the morula--blastocyst stages and transplanted in the uterus of pseudopregnant females. FGF4 and TGFalpha improved the development of parthenogenetic embryos at the preimplantation stages and the number of blastocysts increased under the influence of TGFalpha. All three growth factors improved the implantation of embryos in the uterus. When FGF4 or TGFbeta1 were added to the nutrient medium, 2.4 or 1.6%, respectively, of parthenogenetic embryos reached the somatic stages in utero. No somitic embryos were observed in the control. The treatment of parthenogenetic embryos with two growth factors, FGF4 and TGFbeta1, simultaneously increased the amount of somatic embryos to 7.5%, while combination of three growth factors in creased the amount of such embryos to 16.7%. In the latter case, some parthenogenetic embryos reached the stage of 25-27 pairs of somites and were 2.0-2.5 mm long. The data we obtained suggest that, when combined, the growth factors FGF4, TGFalpha, and RGFbeta1 possessed a synergistic effect leading to a significant improvement of the development of parthenogenetic C57BL/6 embryos.

Animals↗
PubMedDate not supplied

[Cell differentiation of the head ectoderm in mouse embryos in vitro].

Cell differentiation has been studied in the explants of head ectoderm of 8, 9 and 10 day old mouse (CBA) embryos and of head epidermis of 13 day old embryos. Pieces of ectoderm were taken from the temporal region. It was established by indirect immunofluorescence that within 10, 15 and 20 days of cultivation spheroids with keratins or crystallins in some groups of fibres formed in the head ectoderm explants from 9 and 10 day old embryos. When cultivating the regions of head epidermis from 13 day old embryos, spheroids formed with keratin only in their cells. The data obtained suggest that there appear to be two clones of cells determined to the synthesis of keratins or crystallins in the head ectoderm of early mouse embryos. During embryogenesis, the number of cells determined to the synthesis of keratins appears to increase in the regions not related to the eye area. At the same time, the clone of cells determined to the synthesis of crystallins appears to be eliminated.

Animals↗