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Biomedical subjects

O Vanhooteghem

Publications and source records attributed to O Vanhooteghem.

15 recordsLinked to original sources
PubMed2001

[A non-infectious pyodermatitis: Pyoderma gangrenosum].

Pyoderma gangrenosum (PG) is a rare chronic inflammatory skin disease characterized by the recurring development of necrotizing and painful ulcers. The skin lesions appear spontaneously or after minor traumatic injuries. Sites of predilection include the lower limbs and the trunk but any part of the body may be affected. PG is not an infectious disease; although the etiology is not completely understood, an immune disturbance is certainly involved. An underlying systemic disorder is associated in up to 50% of the cases, specially inflammatory bowel diseases, arthritis, paraproteinemias and hematologic malignancies. Chronic venous or arterial ulcers as well as bacterial gangrene are the most frequent false diagnoses. A right diagnosis, based upon the distinctive clinical features and a compatible histology, is essential to avoid surgical procedure that often tends to exacerbed the process. Because of its persistent and recurrent nature, systemic long-term therapy based upon corticosteroids associated with sulfones or immunosuppressive agents is required.

Adrenal Cortex Hormones↗
PubMed1999

Acropathia ulcero-mutilans acquisita of the upper limbs.

We report an 80-year-old woman with a bilateral mutilating acro-osteolysis of the fingers progressing over a period of 3 years. As the patient refused nerve or muscle biopsies, our diagnosis of acropathia ulcero-mutilans acquisita or Bureau-Barrière syndrome, characterized by osteolysis, remains hypothetical. Sporadic sensory mutilating acropathy of the upper limbs is rare, and we discuss the differential diagnosis.

Aged↗
PubMed1999

[Bilateral subungual metastasis from squamous cell carcinoma of the lung: a diagnostic trap!].

We report a bilateral metastasis of the fifth nail unit of the hand in a man with primary squamous-cell carcinoma of the lung. The presence of fingertip metastasis may be the first manifestation of an internal neoplasm and is related to a poor prognosis, with a survival rate of less than 50% after 6 months. Therefore, physicians should be aware of this condition when examining patients with similar unusual lesions.

Bone Neoplasms↗
PubMed1998

Occurrence of gouty tophi following acitretin therapy.

Acitretin (Ro 10-1670 or Neotigason), a free acid and the main metabolite of etretinate (Ro 10-9359 or Tigason), is the most recent of the retinoids used orally in the treatment of psoriasis and numerous other dermatoses exhibiting disorders of keratinization. In the majority of cases, its side-effects are similar to those of hypervitaminosis A.

Acitretin↗
PubMed1997

Pulse steroid therapy for children's severe alopecia areata?

Seven children with severe, rapidly evolving alopecia areata (AA) were treated with pulse steroid therapy (PST). AA had been present for 3-44 weeks and involved more than 30% of the scalp. One patient had alopecia totalis. Intravenous methylprednisolone (5 mg/kg twice a day) was administered for 3 days. No serious side effects were noted. At the 12-month follow-up, complete regrowth had occurred in 5 patients (71%). The patient with alopecia totalis had no regrowth. PST appears to be a promising and safe treatment for extensive, recent-onset AA in children. No response is to be expected in alopecia totalis or long-standing AA.

Adolescent↗
PubMed1997

Tufted angioma, a particular form of angioma.

Tufted angioma is a rare acquired cutaneous angiomatous proliferation characterized by slowly spreading erythematous macules and plaques, sometimes surmounted by nodular formations. Synonyms are progressive capillary hemangioma and Nakagawa's angioblastoma. Tufted angioma appears to be benign since follow-up studies did not report malignant transformation. This lesion must be distinguished from other vascular tumors, especially from Kaposi's sarcoma. If this lesion appears in an older patient, angiosarcoma should be excluded.

Child, Preschool↗
PubMed1997

Docetaxel-induced subungual hemorrhage.

Docetaxel (RP 56976 or Taxotere), a semisynthetic drug belonging to the family of taxoids, is a new chemotherapeutic agent used in phase II trials for breast, ovarian and lung cancer. We report 2 cases of subungual hemorrhages, which, to our knowledge, have yet to be cited in association with the use of docetaxel. Although not incapacitating, the patient should be made aware of the potential risk of this drug reaction.

Adult↗
PubMed1996

Lichen scrofulosorum type tuberculids of the face.

We report the case of a 27-year-old man who presents facial tuberculid of the type lichen scrofulosorum. This presentation stimulates interest in those aspects which cutaneous lesions associated with tuberculosis can manifest. As a consequence of the growing poverty and the flow of new immigrants into our industrialized regions, this pathology is becoming more frequent today.

Adult↗
PubMedDate not supplied

Hermansky-Pudlak syndrome: a case report and discussion.

Hermansky-Pudlak syndrome is a rare, inherited, autosomal recessive disease. Diagnosis is based on a triad of signs: oculocutaneous albinism, a hemorrhagic tendency due to a platelet disorder, and an accumulation of lipopigments in different organs, particularly the medullary macrophages. We describe a child with the characteristic findings of this syndrome, which often goes unrecognized because of the discrete nature of the cutaneous and hemorrhagic manifestations. This diagnosis is important because of the risk not only of hemorrhage but also of granulomatous colitis and long-term pulmonary fibrosis.

Albinism, Oculocutaneous↗
PubMedDate not supplied

Raynaud phenomenon after treatment of verruca vulgaris of the sole with intralesional injection of bleomycin.

Intralesional injection of bleomycin (BLM) for the treatment of warts resistant to all conventional therapies is of certain interest because of the drug's low toxicity and its efficacy. However, delayed side effects may appear, particularly Raynaud phenomenon. Accordingly, some precautions must be taken in patients with vascular or collagen diseases and, as a precaution, pregnant or lactating women and infants should not be treated with this drug.

Anesthetics, Local↗