PubMed Health⌕ Search

Biomedical subjects

O Wagner

Publications and source records attributed to O Wagner.

At least 145 records · Page 8Linked to original sources
PubMed1978

Enhanced prostacyclin availability of blood vessels in uraemic humans and rats.

Recently prostacyclin (PHI2), an unstable prostaglandin with a strong inhibitory effect on platelet aggregation, has been demonstrated in the wall of blood vessels. We estimated the PGI2 availability of arteries and veins in 10 uraemic patients and 12 nephrectomised rats. The production of PGI2 after long-term incubation of the vessels was markedly enhanced and prolonged. This alteration is probably one key mechanism for the deterioration of haemostasis in uraemics. Preliminary results of further studies indicate that substances in uraemic plasma--presumably middle molecules--may enhance the PGI2 availability of normal vessels in vitro.

Animals↗
PubMed1976

[Renal transplantation in children (author's transl)].

During the past 2 years 7 children received kidneys from cadaveric donors. 2 transplants had to be removed because of irreversible chronic rejection and 1 recipient died on the 4th day after surgery. The remaining 4 recipients are doing well. In the evaluation of the results special emphasis is placed on the normalization of growth and puberty. The difficulties of psychosocial rehabilitation are stressed.

Adolescent↗
PubMed1976

[Rejection of a kidney graft after pregnancy and delivery].

Eighteen months after cadaver kidney transplantation a 22-year-old woman was successfully delivered of a healthy female child. Onset of allograft rejection in the third trimenon was followed three weeks after delivery by progressive renal failure and resumption of regular dialysis treatment. Pregnancy risk factors after successful renal transplantation and immunosuppressive therapy are discussed.

Adult↗
PubMed1976

[Urinary enzymes in the early detection of rejection reactions after renal transplantation (author's transl)].

Urinary enzymes were studied in 15 patients subjected to kidney transplantation. The investigation was initiated immediately after operation and was continued for a period of between 2 and 8 weeks. There was a significant increase in urinary MDH activity in 94.2% of cases, of LDH activity in 95,65% and of gamma-GT activity in 95,17% of the cases. This detected increase in urinary enzyme activities preceded the clinical diagnosis of rejection by activities preceded the clinical diagnosis of rejection by at least 24 hours. Determination of these enzymes provides a reliable tool for the early detection of rejection crises.

Enzymes↗
PubMed1976

Corticosteroids and proliferation of smooth muscle cells in arteries of renal transplants.

In the arteries of 17 rejected renal grafts 'activated' smooth muscle cells (ASMC) were discerned from a 'resting' type. Proliferation and fibre production by ASMC resulted in a marked thickening of intima. Each of four normal Wistar rats received 20 mg prednisolone i.v./day for one week and the development of hypertension was therapeutically prevented. Changes similar to those in the graft arteries were found in the rat aortas. We assume that SMC were stimulated by several mechanisms in rejection but also by extremely high dosed corticoids.

Adrenal Cortex Hormones↗
PubMed1975

Quantitative morphological investigations on smooth muscle cells in vascular surgical specimens and their clinical importance.

A distinct distribution of activated SMC could be demonstrated in atherosclerotic plaques and the neighbouring media of human beings. An increased proliferation was found in the younger age group and generally in the marginal regions of the plaques. The occurrence of activated SMC is thought to be a sequel of metabolic hypoxic damages. A high frequency of activated SMC is a bad prognostic sign in surgical specimens indicating a tendency for proliferation and occlusion.

Adult↗
PubMed1975

[Evaluation of results of surgery (author's transl)].

A computerized documentation system for the evaluation of arterial reconstructive procedures has been in practical use within the Austrian Society for Vascular Surgery since 1969. Early and late results of 2103 operations preformed at the 1st Surgical Clinic of the University of Vienna for chronic occlusive disease of the lower extremities are analyzed for function of arterial reconstruction, amputation rate and mortality and the dependence of these on the preoperative stage and the localisation of the occlusion.

Arteriosclerosis↗