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Ole-Bjørn Tysnes

Publications and source records attributed to Ole-Bjørn Tysnes.

4 recordsLinked to original sources
PubMed2002

[Craniocervical artery dissection].

BACKGROUND: In recent years, new radiographic diagnostics have increased our knowledge about dissection of the carotid and vertebral arteries as a cause of stroke, probably an underdiagnosed condition. Carotid dissection is now considered one of the most frequent aetiologies of ischaemic stroke in patients less than 50 years of age and it accounts for 20% of all cases under the age of 30. MATERIAL AND METHODS: In this paper we describe clinical course and investigations in four patients who had dissection of the precerebral arteries. RESULTS: Three patients had carotid artery dissection, one vertebral artery dissection. Three patients had ischaemic symptoms. One patient had symptoms following physiotherapy to the neck. INTERPRETATION: Patients with craniocervical arterial dissection should be investigated with ultrasound techniques and MRI or CT; antiplatelet agents or anticoagulation therapy should be considered.

Aortic Dissection↗
PubMed2002

[Etiology and genetics of Alzheimer disease].

BACKGROUND: Alzheimer's disease (AD) constitutes more than 50% of all dementias. The diagnosis is mainly based on clinical criteria and a definitive diagnosis of AD is made post-mortem with identification of amyloid plaques and neurofibrillary tangles. A small proportion of the patients are under the age of 60 at diagnosis, known as early-onset AD, and most of these cases have an evident genetic component. Aging is the most important risk factor for developing late-onset AD, but also genetic polymorphisms and many environmental conditions play a part in the development of this multifactorial disease. METHODS: The Medline database was searched for "Alzheimer's and genetics". Histologic data were kindly provided from our hospital's department of pathology. RESULTS AND INTERPRETATION: We consider most of the proved etiological factors, especially the three genetic loci which have been shown to be associated with early-onset AD: amyloid precursor protein (APP) gene, presenilin (PS)-1 and PS-2 genes. Mutations in the PS-1 gene at chromosome 14 are by far the most frequent genetic cause of AD. However, the large number of mutations makes genetic screening difficult. We also discuss the impact of the different ApoE alleles in developing late-onset AD, in addition to other mutations and polymorphisms.

Aged↗