PubMed Health⌕ Search

Biomedical subjects

Olle Olsson

Publications and source records attributed to Olle Olsson.

2 recordsLinked to original sources

[Clinical psychoacoustics can support an objective diagnosis of schizophrenia].

This article deals with a new branch of research in psychiatry focusing upon schizophrenia in the first hand. Methods of investigating psychoacoustic aberrations in this disease have been developed during the last twenty years at our laboratory; Unit of Clinical psychoacoustics, Division of Psychiatry, Dept of Clinical Neuroscience, Lund University (www.psykiatr.lu.se/psykoaclab). Schizophrenic persons show dysfunctions at the psychophysiological level as displayed by many psychoacoustic mechanisms such as streaming, restoration and contralateral induction of sounds. These dysfunctions may influence general cognitive and perceptual processes and partly explain clinically observed symptoms of the disease. Further investigations on the efforts to elucidate normal functioning of the psychoacoustic processes by functional magnetic resonance imaging, auditory brainstem response and via animal models are described. One immediate aim of all the studies is to be able to demonstrate objective measurements of the schizophrenic aberrations using psychoacoustic tests. This would help supporting the diagnosis, setting early diagnosis or guide therapeutic decisions.

Animals↗

Auditory masking experiments in schizophrenia.

Twelve schizophrenic subjects with acoustic hallucinations in their case histories were compared with 12 healthy reference subjects and eight subjects with panic disorder in a test of three auditory masking tasks, simultaneous masking (SM), forward masking (FM) and backward masking (BM). The schizophrenic subjects showed no differences from reference subjects on SM but had higher thresholds for the two other conditions (FM and BM). Schizophrenics with very increased thresholds (n=6) had a significantly higher need for residential treatment. Thresholds for SM and BM were not, as for reference subjects, related to age for schizophrenics. No statistically significant differences regarding any masking experiments were found between the panic disorder subjects and the reference subjects. Simultaneous masking, reflecting functions of the basilar membrane and those of elementary brainstem processing, showed no signs of dysfunction in schizophrenic subjects. Schizophrenics showed aberrations in FM and BM, possibly influenced by more central (cortical) processes.

Adult↗