Simultaneous occurrence of nasal and cervical rhinoscleroma.
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Female↗
Biomedical subjects
Omer Uluoğlu
Publications and source records attributed to Omer Uluoğlu.
Interdigitating dendritic cell tumor with breast and cervical lymph-node involvement: a case report and review of the literature.
Interdigitating dendritic cell tumor (IDCT) is an extremely rare malignancy. It occurs primarily in lymph nodes, but extranodal involvement has also been reported. A 38-year-old woman with IDCT with breast and cervical lymph-node involvement is reported in this paper. To our knowledge, this is the first case of IDCT originating from the breast. In the breast and lymph node, the tumor displayed diffuse sheets, fascicles and storiform growth pattern. It was composed of oval to spindle cells with pale to eosinophilic cytoplasm, ill-defined cell outlines, oval nuclei with vesicular chromatin and prominent eosinophilic nucleoli. Mitotic activity was three per ten high-power fields. The neoplastic cells were intermingled with small mature lymphocytes and plasma cells. Immunohistochemical studies showed that the tumor cells were strongly and diffusely positive for vimentin, CD68, S-100 protein, CD45/leukocyte common antigen and fascin and focally positive for lysozyme, alpha-1 antitrypsin and CD4. Ki-67 labeling index was 10%. The patient was treated with combined therapeutic approaches, including surgery, radiotherapy and chemotherapy. IDCT has the potential for an aggressive clinical course. However, 32 months after the initial diagnosis, the patient is still alive and being followed with a stable tumor burden.
Adult↗
Cortically located collecting duct carcinoma.
Collecting duct carcinoma is a rare, highly aggressive, renal tumor arising from the distal collecting ducts. Various histologic patterns can be found in the same tumor but most demonstrate duct-like or papillary architecture surrounded by desmoplastic stroma. Grossly, these tumors are typically located in the medullary portion of the kidney near the region of the pelvis without extensive hemorrhage. It has a tendency to affect young patients and present at more advanced stages with a poorer prognosis. We describe a case of collecting duct carcinoma with histologic and immunohistochemical findings in a cortically located tumor.
Adult↗
Second primary myogenic sarcoma in a patient with bilateral retinoblastoma.
Retinoblastoma is the primary ocular malignancy affecting children under 6 years of age. The development of second malignant tumors in survivors of hereditary retinoblastoma is a well-known clinical entity and a major cause of morbidity and mortality. Rhabdomyosarcomas as second primary tumors have been only rarely described. The authors report a patient with bilateral retinoblastoma who developed a myogenic sarcoma of the orbit after 5.5 years of diagnosis. The short latency period may be explained by tumor histology with the contribution of radiotherapy and chemotherapy. The prognosis of second tumors is poor despite aggressive treatment.
Eye Neoplasms↗
Dirofilaria repens presenting as a premasseteric nodule.
Dirofilariasis is a rare zoonosis that is mainly seen with subcutaneous or pulmonary involvement. Natural hosts are dogs, cats, jackals, and raccoons; however, humans can rarely become an accidental host for the parasite. In the reported case, infection manifested as a subcutaneous nodule, representing a significant diagnostic challenge for both the surgeon and the pathologist. A case of a 62-year-old man with a premasseteric soft tissue mass caused by Dirofilaria repens is presented with histopathologic confirmation.
Adipose Tissue↗
Nonhealing ulcerative mass of the elbow: do not forget tuberculosis.
Skeletal tuberculosis is a rare condition and is seen in only 1 to 2% of all cases of tuberculosis. The authors present a 69-year-old white woman with tuberculosis of the left elbow joint whose disease was suspicious for synovial sarcoma. Skeletal tuberculosis usually conflicts with neoplastic or inflammatory diseases. One should remember the possibility of bone-joint tuberculosis and send biopsy specimens for culture to determine the presence of acid-fast bacilli. However, neither culture nor polymerase chain reaction nor histological examination may be capable of showing the bacilli. Only a suspicion may be enough. The treatment protocol is usually a combination of surgical debridement and multidrug antituberculous chemotherapy.
Aged↗