Biomedical subjects

Onder Kayigil

Publications and source records attributed to Onder Kayigil.

7 recordsLinked to original sources

PubMed2007

Obstructive urodynamic findings in idiopathic detrusor overactivity.

PURPOSE: To investigate the obstructive findings urodynamically in idiopathic detrusor overactivity and compare them (maximum flow rate 'Q max' detrusor pressure at maximum flow 'PQ max') with control group. MATERIALS AND METHODS: Cystometric evaluation and pressure flow studies were performed in 25 women with symptoms of idiopathic detrusor overactivity and control group comprised 40 women with anatomic incontinence without cystocele. Patients with pelvic floor prolapse, motor urgency and poor compliance were excluded from the study. Q max less than 15 ml/s and PQ max more than 40 cm water were accepted as obstruction. RESULTS: After cystometric evaluation, obstruction was found in 36% of patients with idiopathic detrusor overactivity and 15% in control group. The range of maximum flow rate and PQ max values were 2-43.7 ml/s (mean 14.47 +/- 10.22) and 10-143 cm water (mean 58.97 +/- 35.13) in idiopathic urge syndrome group. These values were 6.6-51.8 ml/s (mean 23.24 +/- 12.43) and 9.7-61 cm water (mean 25.56 +/- 12.43) respectively in control group. Q max and PQ max parameters were compared statistically between the two groups. Idiopathic detrusor overactivity group had lower mean Q max and higher mean PQ max values than control group (P < 0.001) Table 1. CONCLUSION: Obstruction percentage was found to be more in idiopathic detrusor overactivity group than the control group.

Adult↗

PubMed2005

Electromyographic changes after deep dorsal vein arterialization.

PURPOSE: To investigate the cavernosal electromyographic changes after deep dorsal vein arterialization. PATIENTS AND METHODS: Corpus cavernosum electromyographs (CC-EMG) were done in 18 patients with patent anastomosis 1 year after the operation by using coaxial needle electrodes during the flaccid state and following intracavernous 60 mg papaverine injection. RESULTS: The mean preoperative amplitude and relaxation degree measurements were found to be 77 +/- 11 microV and 34 +/- 8%, respectively. The same recordings 1 year after the operation were 140 +/- 24 microV and 76 +/- 11%, respectively. Comparisons of preoperative and postoperative values revealed statistically significant results (p < 0.0001). CONCLUSION: Smooth muscle restoration of cavernous tissue was proved by observing the postoperative increases in the amplitude and relaxation degree parameters of CC-EMG.

Adult↗

PubMed2005

Does lidocaine ointment addition increase fluoxetine efficacy in the same group of patients with premature ejaculation?

PURPOSE: To evaluate the efficacy of fluoxetine alone and fluoxetine+lidocaine ointment in the same patient group with premature ejaculation (PE). MATERIAL AND METHODS: 78 patients with PE were given 20 mg fluoxetine by an 'as-needed treatment' 4 h before planned sexual activity for a period of 3 months. They were then told to add local lidocaine ointment to fluoxetine 30 min before sexual activity for an additional 3 months for most of their sexual attempts. They were asked to note their PE grades and intravaginal ejaculatory latency time (IELT) scores by stopwatch technique before and after each treatment modality; the results were compared statistically afterwards. RESULTS: Of 46 patients who completed the study, the mean pretreatment, fluoxetine alone and fluoxetine+lidocaine ointment treatment PE grades and IELT scores were found to be 6.52+/-1.42 and 2.58+/-0.49, 3.21+/-1.86 and 1.28+/-0.71, 2.17+/-1.56 and 1.04+/-0.72, respectively, showing a decrease in PE grades and IELT scores in combined therapy. On an individual patient basis, the total significant and moderate improvement rate of combined therapy was found to be 86.9%. Failure was observed in 6 (13.1%) patients. CONCLUSION: The effective treatment with fluoxetine+lidocaine ointment offers the advantage of an 'as-needed treatment' in PE with minimal side effects and can be used as one of the first-line alternatives in the treatment of PE.

Administration, Oral↗

PubMed2005

The efficacy of human chorionic gonadotropin in retractile testis.

OBJECTIVES: To evaluate the efficacy of hCG therapy on retractile testis in various testicular locations and age groups. SETTING AND DESIGN: This study comprised 123 boys whose diagnosis were retractile testis with scrotal base, high scrotal and superficial inguinal localizations with an average age of 4,2 (1-8) years. METHODS: 123 boys with retractile testes were given a total dose of 9000 hCG and its effect on scrotal base, high scrotal and superficial inguinal located testes were evaluated after 2 weeks and 6 months of completing hCG course. The patients were evaluated in four age groups such as less than 2 years of age, between 2-4, 4-6 years and more than 6 years of age and the response rates were also noted in these age groups. RESULTS: In unilateral cases, the response in base, high scrotal and superficial inguinal levels were found as 100%, 83,3%, 72,7% respectively where as these rates were found as 100%, 92,6%, 76,3% respectively in bilateral cases after 2 weeks of hCG therapy. The response rates in less than 2 year old group, 2-4, 4-6 and more than 6 years group were found as 0%, 80%, 78,7%, 100% respectively in unilateral cases and 33,3%, 90%, 86,9% and 83,3% respectively in bilateral cases. After 6 months, reascend was observed in 12,4% in unilateral group and 6,7% in bilateral group. MAIN FINDINGS: 72,7-100% of retractile testes respond to hCG administration with the highest response in the age of more than six year group. CONCLUSION: High response rates observed in retractile testes after hCG therapy in more than 2 years old age group indicate that hCG must be given as a primary treatment in retractile testes and orchiopexy for the failures. Also patients must be followed up closely for reascend cases.

Aging↗

PubMed2003

Side firing Neodymium:Yag laser prostatectomy: six years of experience with 170 patients.

OBJECTIVES: To evaluate the results and complications in 170 patients with symptomatic benign hyperplasia who underwent laser prostatectomy focusing on six month and long-term results. METHODS: A total of 170 patients underwent side firing Neodymium:Yag laser prostatectomy between January 1995 and February 2001 of whom 152 and 82 were available after 6 months and 3 years follow-up respectively. Evaluations were done by American Urological Association (AUA) symptom score, peak urinary flow rate, residual volumes and immediate and long-term complications were assessed. RESULTS: Median patient follow-up period was 34.1 months (16-70). After 6 months the mean AUA score reduced from 20.2 to 8.2 and found as 9.4 in patients who completed 3 years follow-up. Post voiding urine volume decreased from 110 ml to 46 ml at 6 months and found as 60 ml after 3 years. Peak urinary flow rate increased from 3.4 to 16.4 ml per second after 6 months and found as 14.8 ml per second after 3 years. The overall complications of 170 patients in early period included urinary retention after catheter removal in 6 (3.52%), early bleeding in 2 (1.17%), late bleeding in 1 (0.58%). Late complications included urethral stricture requiring internal urethrotomy in 12 (7.8%), bladder neck contracture in 4 (2.6%) and repeated laser prostatectomy after 2 years in 10 (5.88%) patients. CONCLUSION: Side firing Neodymium:Yag laser prostatectomy offers a safe and effective treatment for bladder outlet obstruction due to benign hyperplasia with minimal associated morbidity.

Follow-Up Studies↗

PubMed2002

Plaque incision and venous patch grafting for Peyronie's disease.

PURPOSE: To evaluate the results of plaque incision and venous patch grafting to correct the dorsal curvature associated with Peyronie's disease. MATERIALS AND METHODS: 18 patients with Peyronie's disease were treated surgically. All of the patients have dorsal penile curvature for more than one year causing intromission impossible or with some difficulty because of curvature. Median penile angulatio was 60 degrees (range 45 degrees-75 degrees). A transverse incision about 2 cm long was made on the plaque where maximal site of curvature was identified. The saphenous vein harvested from the ankle region is opened longitudinally and its endothelial surface is placed and sutured in contact with the tunical defect. RESULTS: Complete penile straightening was achieved in 16 (88.8%) cases and only two patients have residual curvature less than 30 degrees permitting sexual intercourse. None of the patients returned to baseline preoperative angulation state in the follow up period. 3 patients (16.6%) reported penile shortening, but only one was concerned and showed dissatisfaction about it. 6 patients (33.3%) have transient changes in penile sensation that resolved within 4 months. CONCLUSIONS: Plaque incision and placement of saphenous vein patch graft offers a 94.4% satisfactory result in Peyronie's disease causing penile dorsal curvature.

Aged↗

PubMed2002

Double forced sling by combining in situ vaginal wall and Infast pubic bone suburethral stabilization techniques: a new method.

PURPOSE: We evaluated the results and effectiveness of the double forced sling by combining in situ vaginal wall and Infast (Influence, Inc., San Francisco, California) pubic bone suburethral stabilization techniques as a new method. MATERIALS AND METHODS: The new technique was used in 40 patients, of whom 32 completed 2 years of followup. Previous surgery included hysterectomy in 8 cases, anterior and posterior vaginal wall repair in 6, and 1 or 2 incontinence procedures in 24. Types 2, 3 and mixed incontinence were diagnosed in 12, 12 and 8 patients, respectively. With this technique a gelatin coated synthetic sling was fixed to the previously prepared vaginal sling surface with watertight stitches to create a doubled forced sling, which was fixed to the pubic bone with 2 screws using an Infast inserter. Patient outcomes were evaluated by questionnaire analysis and the pad test. RESULTS: The cure, improvement and failure rates were 81.25%, 6.25% and 12.5% in the 32 patients who completed 2 years of followup. Surprisingly successful results were achieved in all 24 secondary cases. Moderate cystocele in 4 patients and rectocele in 8 were corrected simultaneously. Temporary urinary retention in 4 patients resolved in 2 weeks. Of the 32 patients 28 reported that they would repeat the procedure and recommend it to others. CONCLUSIONS: The double forced sling has 2 advantages that make it superior to other techniques, namely a minimal complication rate and enhanced support accomplished by an easy and noninvasive technique.

Adult↗