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Biomedical subjects

Onder Us

Publications and source records attributed to Onder Us.

7 recordsLinked to original sources
PubMed2006

Normative data for lateral femoral cutaneous nerve SEPs.

AIMS OF THE STUDY: To determine normative values for somatosensory evoked potentials (SEPs) of the lateral femoral cutaneous nerve (LFCN). METHODS: The LFCN was stimulated at two points, one located 1 cm lateral to the midpoint of a line joining the anterior superior iliac spine (ASIS) and the patella (31 subjects), and the other one located 12 cm distal to the ASIS (24 subjects). Recordings were performed at Cz' (2 cm behind Cz)-Fz. RESULTS: Reproducible SEPs were obtained in all but one of the 31 subjects to ASIS-patella midpoint (mean P1 latency: 33.2+/-3.5 ms, mean side-to-side difference: 2.0+/-1.6 ms) and in all but three of the 24 subjects to stimulation 12 cm distal to the ASIS (mean P1 latency: 30.9+/-3.3 ms, mean side-to-side difference: 2.2+/-1.7 ms). CONCLUSIONS: Reliable SEPs can be obtained to LFCN stimulation. It is easier and, therefore, more convenient to stimulate the ASIS-patella midpoint.

Adolescent↗
PubMed2006

Evaluation of the angiotensin-converting enzyme insertion/deletion polymorphism and the risk of ischaemic stroke.

Angiotensin-converting enzyme (ACE) gene polymorphism has been associated with increased incidence of stroke in some populations, although contradictory results have been reported. The aim of this study was to determine the allelic frequency and the genotypic distribution for ACE gene polymorphism in Turkish patients with ischemic stroke compared to appropriate healthy controls and to correlate the genetic findings with stoke type. One hundred and eight patients with ischemic stroke versus 79 healthy controls were studied for the presence of ACE gene polymorphism detected by PCR. Genotypes were defined as DD, II and ID according to the presence of the D (deletion) and I (insertion) alleles. There was no statistically significant difference in either the genotypic distribution or allelic frequency between the patients versus healthy controls (chi2 = 0.105; df = 1; p = 0.430). There was also no significant difference for ACE genotype distribution and allelic frequency within the stroke group classified according to Bamford criteria (chi2 = 4.827; df = 3; p = 0.185). Our data supports lack of association between DD genotype and/or D allele and ischemic stroke or subtypes of ischaemic stroke in the Turkish population.

Aged↗
PubMed2006

Effects of high stimulus frequencies on SEPs of patients with neuro-Behcet's Disease.

BACKGROUND: Behcet's disease is a multisystemic vascular inflammatory disorder of unknownorigin. It is relatively rare and central nervous system involvement is seen in 5% of affected individuals. Somatosensory evoked potentials (SEPs) can provide information that shows the presence of clinically unsuspected lesions in the central nervous system of these patients. However, the effects of changing the stimulus frequencies on latencies of SEP potentials and central conduction time (CCT) in patients with neuro-Behcet's disease (NB) have not been studied yet. In this study, our aim was to reveal these effects to investigate whether the change of stimulus frequencies could be of convenient use in obtaining more accurate CCT estimations in SEP studies of these patients. METHODS: We performed median nerve SEPs of 14 patients with NB and 15 healthy volunteers. We changed the stimulus frequency: 2 Hz, 4Hz, 6Hz and 9Hz in successive recordings and statistically compared the changes on SEP potentials and peak and onset CCT in the neuro-Behcet (NB) group and the normal group. RESULTS: Our results indicated that the onset CCT values of the NB group were higher than the normal group at 4Hz and 9Hz stimulations. However, the comparison of peak CCT in the NB group and the normal group did not show any statistically meaningful differences at all stimulation frequencies. CONCLUSION: Onset CCT has not been measured before in former SEP studies of patients with NB. We highly recommend measuring onset CCT at higher stimulation frequencies in order to reveal central conduction time pathologies in these patients.

Adult↗
PubMed2005

A comparison of F waves in peripheral nerve disorders.

BACKGROUND AND AIM: F waves have become integral parts of nerve conduction studies in particular. F minimum (Fmin), the most commonly assessed latency, represents the largest and the fastest conducting fibers. The diagnostic yields of other F wave parameters are not obvious. In the present study, we aimed to determine the value of F wave parameters in commonly seen peripheral nerve disorders. MATERIAL AND METHOD: We studied the F responses in 118 patients who had been diagnosed with different types of neuropathies, clinically and electrodiagnostically, and 68 individuals were used as controls: A total of 470 motor nerve conduction studies and related F-wave parameters were analyzed. DISCUSSION: F maximum (Fmax) was the most commonly seen abnormal parameter in the present study, although Fmin has until now been the most commonly studied parameter in clinics routinely. Abnormalities of F waves were more frequently seen in the patients compared to those in the control group and the differences were significant for carpal tunnel syndrome and upper extremity radiculopathies. CONCLUSION: This large database showed that F wave evaluations should include not only Fmin but also Fmax.

Adult↗
PubMed2004

Involvement of sympathetic reflex activity in patients with acute and chronic stroke: A comparison with functional motor capacity.

OBJECTIVE: To investigate sympathetic nervous system functions in patients with acute and chronic phase of stroke by measuring sympathetic skin reflex (SSR) and the relationship between sympathetic dysfunction and motor function capacity. DESIGN: Cross-sectional, case-control study. SETTING: A physical medicine and rehabilitation department in a research hospital of a university referral center in Turkey. PARTICIPANTS: Fifty-six patients with stroke-13 in the acute phase and 43 in the chronic phase-and 42 age- and sex-matched healthy volunteers were included. INTERVENTION: SSR was recorded with electric stimulation of the bilateral median nerves. MAIN OUTCOME MEASURES: SSR was recorded to assess sympathetic reflex activity in patients in the acute and chronic phase of stroke and in controls. Motor functions was classified using the Brunnstrom stages. RESULTS: The mean SSR latency in the acute phase was significantly prolonged and the amplitudes were decreased compared with controls. In the chronic phase, the mean amplitudes were significantly attenuated compared with controls, whereas the mean latency did not change. The mean latency of SSR in patients in Brunnstrom groups 1 and 2 was longer, and the mean amplitude was smaller than in controls (P<.05). The mean amplitude was significantly reduced in patients classified as Brunnstrom groups 3 and 4 compared with controls (P<.05), but the mean latency was not affected. CONCLUSIONS: Depression of sympathetic reflex activity was more prominent in the acute phase of stroke and was associated with moderate or highly limited motor function capacity. Improvement of motor dysfunction may parallel recovery of sympathetic reflex activity.

Acute Disease↗
PubMed2003

Visual and auditory event related potentials in epileptic children: a comparison with normal and abnormal MRI findings.

Visual and auditory event related potentials (VERPs and AERPs) in 32 epileptic children with magnetic resonance imaging (MRI) abnormalities and 18 with normal MRI were recorded and compared to the data of 21 healthy children. Of all 50 epileptic children (34 male, 16 female) aged 14.42+/-4.27 (7-20) years, 21 were medically intractable and receiving polytherapy. The mean latencies of N2 and P3 components of VERPs and AERPs in all epileptic children were significantly higher than those of the controls (P<0.05). Epileptic children with structural abnormalities had more prolonged latencies of N2 and P3 components of AERPs and VERPs than those of the healthy children (P<0.05). The epileptic children with normal MRI had significantly more prolonged latency of N2 and P3 of VERPs and P3 of AERPs than those of the controls (P<0.05). The difference of the mean latency of N2 and P3 components or the mean amplitude of P3 components of ERPs between the two epileptic groups was insignificant. The type of medication (mono- versus polytherapy) did not affect the wave components of ERPs. We suggest that epileptic activity, itself, leads to prolonged N2 and P3 components of AERPs and VERPs. The presence of structural abnormality indicated by imaging is not a predictor of ERPs abnormalities.

Adolescent↗