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Biomedical subjects

Osamu Honmo

Publications and source records attributed to Osamu Honmo.

2 recordsLinked to original sources

[A case of oligodendroglioma with temporal lobe epilepsy initially suspected as having paroxymal tachycardia].

A 4-year-old girl had repetitive attacks of chest pain, palpitation and loss of consciousness, which lasted for a few minutes and occurred several times a day. Interictal and ictal EEGs revealed that these episodes were complex partial seizures with autonomic symptoms originating from the right antero-temporal area. Brain MRI depicted a tumor in the right temporal lobe, the suspected etiology of the seizures. The tumor and its surrounding area were carefully resected using electrocorticogram. Pathologically, the tumor was diagnosed as an oligodendroglioma. MR spectrometry demonstrated a definite reduction of NAA/creatine ratio in the tumor. It is reported that a probability of developing seizures in cases of oligodendroglioma is about 80-90%. The occurrence rate of seizures in oligodendroglioma is much higher than that in other brain tumors. The cause of the epileptogenesis in oligodendroglioma might be due to the pathological tissue of satellitosis and secondary degeneration of neurons.

Brain Neoplasms↗

[A stem cell therapy for stroke].

It has been reported that the adult mammalian harbors stem cells or progenitors that retain the potential for both neural production and differentiation. Recently, several progenitors derived from non-neural samples as well as the neural tissues in humans are thought to be a good candidate for the regenerative medicine. Multipotent embryonic stem cells prepared from the fertilized egg or neural stem cells from fetus may be used as allotransplants. Progenitors derived from adult brain, bone marrow, code blood, or lipid can be used as autotransplants. Bone marrow in adult mammals contains several types of precursor and stem cells such as hematopoietic stem cells, non-hematopoietic stem cells, and other unknown precursor cells. The distinct population of progenitor cells in the bone marrow are thought to retain the potential for both neural production and differentiation, and may contribute to a therapeutic strategy for stroke. In the present report, the possible therapeutic strategy of the stem cell transplantation for the stroke is discussed.

Animals↗