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Osamu Kamisawa

Publications and source records attributed to Osamu Kamisawa.

6 recordsLinked to original sources
PubMed2004

Increase in circulating endothelial progenitor cells after aortic aneurysm repair.

Rapid endothelialization of prosthetic vessels is essential to avoid fatal complications. We hypothesized that there may be mobilization of endothelial progenitor cells (EPCs) in patients who received aortic aneurysm repair, and measured the number of CD34-expressing EPCs (CD34(+) cells) in these patients. Blood samples were taken preoperatively, 6, 24, and 48 h, and 7 days after surgery in 13 patients with aortic aneurysm. Samples were also obtained from ten age-matched control subjects. The number of CD34(+) cells in the peripheral blood was quantified by flow cytometry. The levels of serum vascular endothelial growth factor (VEGF) were measured using an enzyme-linked immunosorbent assay kit. Baseline CD34(+) cell counts in the peripheral blood showed a tendency to be lower in patients with aortic aneurysm compared with healthy control subjects. The number of CD34(+) cells did not change over 48 h after aortic aneurysm repair; however, it had doubled by the 7th day. On the other hand, the baseline serum VEGF levels did not differ between the patients and control subjects. The VEGF levels increased gradually after vascular repair with a significant elevation after 48 h, which was followed by an increase in CD34(+) cell counts. In conclusion, the circulating CD34(+) cell counts and serum VEGF levels are increased after vascular prosthesis replacement in patients with aortic aneurysm, which might contribute to the rapid endothelialization of prosthetic vessels.

Antigens, CD34↗
PubMed2003

When and how does nonstructural mechanical prosthetic heart valve dysfunction occur?

OBJECTIVE: We discuss the clinical aspects related to mechanical valve dysfunction based upon 20 years' experience of our cases. METHODS: Between January 1982 and December 2001, 21 patients underwent surgical interventions because of mechanical valve dysfunction. Thirteen men and 8 women (mean age 47 +/- 20, range 3-75 years-old), were included. RESULTS: Mitral valve dysfunction was observed in 12 patients. Prosthetic valve stenosis occurred in 6 patients between 2 and 224 months, and paravalvular leaks in 4 between 1 and 71 months after surgery. The other 2 patients suffered from hemolytic anemia with mild paravalvular leaks between 102 and 104 months after surgery. Aortic valve dysfunction was observed in 8 patients including 3 stenotic lesions between 48 and 97 months and 5 paravalvular leaks between 3 and 150 months after surgery. Tricuspid regurgitation was seen in 1 patient with a huge right atrium at 42 months after surgery. Early death was seen in 1 patient. Late death occurred in 1 patient, 17 years after operation. Survival, including early death, was 95.2%, at 10 and 15 years. One valve-related complication of bioprosthetic valve endocarditis at the mitral and tricuspid positions occurred 12 years after a reoperation. The freedom from complications was 95.2% at 10 years, and 76.2% at 15 years. CONCLUSIONS: Paravalvular leaks without overt endocarditis had latency periods of up to 12 years, and pannus formation was observed 20 years after surgery. Early and late clinical results after surgery for mechanical valve dysfunction were excellent.

Adolescent↗
PubMed2003

Isolated traumatic vertebral pseudoaneurysm: report of a case.

We report a case of isolated traumatic pseudoaneurysm of the vertebral artery in a 20-year-old man who suffered blunt injury to the left foreneck and arm in a traffic accident. A chest computed tomography (CT) scan on admission showed an upper mediastinal hematoma, but the patient's vital signs were stable. A CT scan of the head and neck showed a cerebral mass, and an elective cerebral four-vessel angiography was performed, which revealed a pseudoaneurysm in the proximal portion of the left vertebral artery. At surgery, about 2 cm of the left vertebral artery was found to be lacerated, and suture ligation was done on each side of the laceration. Postoperative intravenous digital subtraction angiography showed an intact right vertebral artery with no residual pseudoaneurysm. There were no neurological complications and the patient was discharged on the 16th postoperative day.

Adult↗
PubMed2002

Successful surgical treatment of chronic traumatic thoracic aneurysm in two patients.

We successfully treated two patients with chronic traumatic aneurysm of the thoracic aorta. The first, a 40-year-old man involved in an automobile accident 24 years earlier, was treated by thoracic aorta graft replacement via left thoracotomy under femoro-femoral partial bypass. The second, a 57-year-old man with a 3-month history of hoarseness who had suffered blunt chest trauma 17 years earlier, was treated similarly. Both had a calcified pseudoaneurysm at the isthmus of the descending aorta, but neither had atherosclerosis other than at the aneurysm site. They have done well after surgery. We believe chronic traumatic thoracic aneurysm at the aortic isthmus should be treated surgically soon after diagnosis because elective surgery presents low risk of morbidity and mortality.

Adult↗
PubMed2002

Single-center experience with the bicarbon bileaflet prosthetic heart valve in Japan.

We analyzed midterm results using the Bicarbon valve in a single center. Forty-four patients had aortic valve replacement (AVR), 48 had mitral valve replacement (MVR), and 13 had both aortic and mitral valve replacement (DVR). The mean age of the 105 patients was 61.2 +/- 11.3 years. The mean follow-up was 1.8 +/- 1.1 years with a cumulative follow-up of 188 patient-years. There were 5 early deaths (4.7%: 4 in the AVR group and 1 in the MVR group) and 5 late deaths (2.7% per patient-year: 3 malignancy, 1 cerebral hemorrhage, 1 myocardial infarction). Survival at 3 years was 91 +/- 4% in the AVR group, 92 +/- 5% in the MVR group, and 66 +/- 23% in the DVR group. The linearized incidence of thromboembolic complications, hemorrhagic complications, and paravalvular leaks in all patients was 1.06 +/- 2.34%, 1.60 +/- 2.53%, and 0.53 +/- 2.22% per patient-year, respectively. No other complications were observed. In conclusion, the Bicarbon prosthetic heart valve has shown excellent clinical results associated with a low incidence of valve-related complications.

Aged↗