Biomedical subjects

Osman A Basaran

Publications and source records attributed to Osman A Basaran.

10 recordsLinked to original sources

PubMed2006

Repeated formation of fluid threads in breakup of a surfactant-covered jet.

Breakup of thin threads is widely observed in nature and technology. As a surfactant-covered liquid jet approaches breakup, its profile consists of a periodic pattern of drops connected by thin threads. Near the locations where the threads join the drops, simulations show that a series of thinner threads arise as the jet breaks. That threads can continue to form repeatedly without addition of noise when surfactants are present is unexpected based on earlier studies of surfactant-free systems. Thinning dynamics of successive threads are shown to be self-similar and approach Eggers's universal solution for clean interfaces.

Journal Article↗

PubMed2006

Dripping of a liquid from a tube in the absence of gravity.

In zero gravity, liquid does not drip from a tube but hangs from it for all time as a pendant drop. It is shown that a drop can be made to fall off a tube by heating the contact line (CL), which causes a temperature gradient between the drop's CL and its tip. Simulations show that whether a drop detaches from or remains attached to the tube is set by the competition between the Marangoni stress that causes flow away from its CL, where the surface tension is low, toward its tip, where is high, and the capillary pressure that causes flow from the tip back toward the CL. The method can be used to make microscopic (nanoscopic) drops by dripping in ordinary gravity, which had heretofore been unattainable.

Journal Article↗

PubMed2005

A finite element based algorithm for determining interfacial tension (gamma) from pendant drop profiles.

This paper introduces a robust algorithm to determine the interfacial tension (gamma) from pendant drop profiles using the Galerkin finite element method (gamma-PD-FEM) to solve the axisymmetric form of the Young-Laplace (YL) equation. In this algorithm, the theoretical profiles are generated by solving the spherical coordinate form of the YL equation. gamma-PD-FEM also solves for the parameter estimates by minimizing the difference between the theoretical and experimental surface functions, f(theta). This technique is compared to the widely used method of converting the YL equation to the three arc length-based (ALB) first-order ODEs developed by Bashforth and Adams (BA) in 1883, or as denoted in this paper, the gamma-PD-BA method. The drop apex is the initial condition for the gamma-PD-BA algorithm and the integration is terminated at a specified location along the drop profile. In contrast to techniques based on the BA approach, computation of the theoretical drop profile in gamma-PD-FEM is obtained from a second-order ordinary differential equation and requires boundary conditions at the drop apex and at the contact line of the drop to the nozzle. By incorporating both boundary conditions into the problem formulation, the algorithm can also determine if the drop shape is at static equilibrium. Results to be presented include an outline of the computer algorithm, and comparison of gamma values obtained from the gamma-PD-FEM and the traditional gamma-PD-BA method using simulated and experimental drop profile data sets.

Journal Article↗

PubMed2004

Effects of soluble surfactants on the deformation and breakup of stretching liquid bridges.

Surfactants are routinely used to control the breakup of drops and jets in many applications such as inkjet printing, crop spraying, and DNA or protein microarraying. The breakup of surfactant-free drops and jets has been extensively studied. By contrast, little is known about the closely related problem of interface rupture when surfactants are present. Solutions of a nonionic surfactant, pentaethylene glycol monododecyl ether, or C12E5, in water and in 90 wt % glycerol/water are used to show the effects of surfactant and viscosity on the deformation and breakup dynamics of stretching liquid bridges. Equilibrium surface tensions for both solutions can be fitted with the Langmuir-Szyskowski equation. All experiments have been done at 24 degrees C. The critical micelle concentrations for C12E5 are 0.04 and 0.4 mM in water and the glycerol/water solution, respectively. With high-speed imaging, the dynamic shapes of bridges held captive between two rods of 3.15 mm diameter are captured and analyzed with a time resolution of 0.1-1 ms. The bridge lengths are 3.15 mm initially and about 5-7 mm at pinch-off. Breakup occurs after stretching for about 0.2-0.3 s, depending on the solution viscosity and the surfactant concentration. When the liquid bridges break up, the volume of the sessile drop left on the bottom rod is about 3 times larger than that of the pendant drop left on the top rod. This asymmetry is due to gravity and is influenced by the equilibrium surface tensions. Surfactant-containing low-viscosity water bridges are shown to break up faster than surfactant-free ones because of the effect of gravity. With or without surfactant, water bridges form satellite drops. Surfactant-containing high-viscosity glycerol/water bridges break up more slowly than surfactant-free ones because of strong viscous effects. Moreover, the shapes of the sessile drops close to breakup exhibit a "pear-like" tip; whether a satellite forms depends on the surface age of the bridge before stretching commences. These unexpected effects arising from the addition of surfactants are due to the capillary pressure reduction and Marangoni flows linked to dynamic surface tension.

Journal Article↗

PubMed2004

Dripping-jetting transitions in a dripping faucet.

Fascinating dynamics is known to result when the flow rate Q at which water drips from a faucet varies. Starting with simple (period-1) dripping, the system transitions as Q increases to complex dripping, where it exhibits period-n (n=2,4, em leader ) and chaotic responses, and then jets once Q exceeds a threshold. New experiments and simulations show that high viscosity (micro) liquids, e.g., syrup, transition directly from simple dripping to jetting as Q increases. Phase diagrams showing transitions between simple and complex dripping and jetting in (Q,micro) space are developed. Values of Q for transition from dripping to jetting are estimated from scaling arguments and shown to accord well with simulations.

Computer Simulation↗

PubMed2004

Solvent exchange method: a novel microencapsulation technique using dual microdispensers.

PURPOSE: A new microencapsulation method called the "solvent exchange method" was developed using a dual microdispenser system. The objective of this research is to demonstrate the new method and understand how the microcapsule size is controlled by different instrumental parameters. METHOD: The solvent exchange method was carried out using a dual microdispenser system consisting of two ink-jet nozzles. Reservoir-type microcapsules were generated by collision of microdrops of an aqueous and a polymer solution and subsequent formation of polymer films at the interface between the two solutions. The prepared microcapsules were characterized by microscopic methods. RESULTS: The ink-jet nozzles produced drops of different sizes with high accuracy according to orifice size of a nozzle, flow rate of the jetted solutions, and forcing frequency of the piezoelectric transducers. In an individual microcapsule, an aqueous core was surrounded by a thin polymer membrane; thus, the size of the collected microcapsules was equivalent to that of single drops. CONCLUSIONS: The solvent exchange method based on a dual microdispenser system produces reservoir-type microcapsules in a homogeneous and predictable manner. Given the unique geometry of the microcapsules and mildness of the encapsulation process, this method is expected to provide a useful alternative to existing techniques in protein microencapsulation.

Capsules↗

PubMed2003

A new process for making reservoir-type microcapsules using ink-jet technology and interfacial phase separation.

A new microencapsulation technique that utilizes interfacial mass transfer between two mutually soluble liquids has been developed. The technique is based on formation of a solid polymer film at the interface of a solution of a water-insoluble polymer and an aqueous solution, resulting from the mutual mass transfer of solvents (i.e., solvent exchange). Reservoir-type microcapsules were prepared by inducing this phenomenon to occur on the surface of an aqueous droplet. One method of implementation employed a dual microdispenser system that consisted of two ink-jet nozzles. The nozzles, producing droplets of a polymer solution and an aqueous drug solution, respectively, were aligned to allow collision of pairs of the droplets. The collision resulted in spreading of the polymer solution on the aqueous droplet and simultaneous solvent exchange, to form a polymeric membrane around the aqueous droplet. The formation of the polymer membrane depended largely on the favorable spreading of the polymer solution on the aqueous droplets and fast solvent exchange, and required judicious selection of the organic solvent. Simple and fast screening methods were developed for selection of a proper solvent. Ethyl acetate was chosen as one of the most desirable solvents through the screening procedures. Ethyl acetate and the dual microdispenser system were used to form microcapsules that were subsequently examined by microscopic methods to demonstrate their unique geometry.

Acetates↗

PubMed2003

Persistence of memory in drop breakup: the breakdown of universality.

A low-viscosity drop breaking apart inside a viscous fluid is encountered when air bubbles, entrained in thick syrup or honey, rise and break apart. Experiments, simulations, and theory show that the breakup under conditions in which the interior viscosity can be neglected produces an exceptional form of singularity. In contrast to previous studies of drop breakup, universality is violated so that the final shape at breakup retains an imprint of the initial and boundary conditions. A finite interior viscosity, no matter how small, cuts off this form of singularity and produces an unexpectedly long and slender thread. If exterior viscosity is large enough, however, the cutoff does not occur because the minimum drop radius reaches subatomic dimensions first.

Journal Article↗

PubMed2003

Computation of dynamic adsorption with adaptive integral, finite difference, and finite element methods.

Analysis of diffusion-controlled adsorption and surface tension in one-dimensional planar coordinates with a finite diffusion length and a nonlinear isotherm, such as the Langmuir or Frumkin isotherm, requires numerical solution of the governing equations. This paper presents three numerical methods for solving this problem. First, the often-used integral (I) method with the trapezoidal rule approximation is improved by implementing a technique for error estimation and choosing time-step sizes adaptively. Next, an improved finite difference (FD) method and a new finite element (FE) method are developed. Both methods incorporate (a). an algorithm for generating spatially stretched grids and (b). a predictor-corrector method with adaptive time integration. The analytical solution of the problem for a linear dynamic isotherm (Henry isotherm) is used to validate the numerical solutions. Solutions for the Langmuir and Frumkin isotherms obtained using the I, FD, and FE methods are compared with regard to accuracy and efficiency. The results show that to attain the same accuracy, the FE method is the most efficient of the three methods used.

Adsorption↗

PubMed2002

Computational and experimental analysis of pinch-off and scaling.

Pinch-off and scaling during drop formation are studied using high-accuracy computation and ultrafast, high-resolution imaging. The interface of a water drop (viscosity mu is approximately 1 cP) is shown to overturn prior to breakup for the first time in experiments, well before the dynamics transitions from the potential flow (PF) to the inertial-viscous (IV) regime. A drop of 83% glycerol-water solution (mu is approximately 85 cP) is shown to exhibit a transition from the PF to the IV regime both computationally and experimentally. The computed value of the minimum neck radius in the latter case follows Eggers's universal solution until it becomes unstable.

Journal Article↗