Biomedical subjects

Osman Dönmez

Publications and source records attributed to Osman Dönmez.

6 recordsLinked to original sources

PubMed2005

Catheter-related complications in children on chronic peritoneal dialysis.

Catheter-related complications--including infection, dialysate leak, subcutaneous leak, outflowfailure, and malfunction--are the principal causes of peritoneal dialysis (PD) failure. In the present retrospective study, we evaluated the catheter-related complications that occurred in children at our facility who were started on chronic PD during the period from July 1997 to August 2004. During the study period, 72 catheters were placed in 53 patients (28 girls, 25 boys). The average follow-up period was 29.4 + 19.3 months. Catheter-related complications developed in 41 patients. The risk for subcutaneous dialysate leak was no more significant when PD catheters were used early (< or = 7 days post placement) than when use was delayed (>7 days). Similarly, no significant difference was observed in the infection rate between the early- and delayed-use groups. During the study, 87 episodes of peritonitis occurred in 39 patients (1 episode / 18 patient-months). The infection rate was significantly different (p < 0.05) in patients with a low serum albumin level. No significant difference was seen between the early--and delayed--use groups in dialysis duration or number of catheter changes. However, we did observe a significant difference (p < 0.05) in subcutaneous leaks with longer dialysis duration. No correlation was observed between early or delayed catheter use and infection, dialysate leak, hernia, or subcutaneous leak. In conclusion, we observed no significant differences in catheter-related complications between early- and delayed-use catheter groups. A low serum albumin level appears to be a risk factor for infection after PD catheter placement.

Catheters, Indwelling↗

PubMed2004

Hemoperfusion in a child with amitriptyline intoxication.

Tricyclic antidepressant overdose is one of the most common causes of serious drug poisoning in children and adults. We report a 17-month-old girl with severe amitriptyline intoxication. She was admitted to hospital because of lethargy and seizures. It was estimated that she took approximately 75 mg/kg of amitriptyline 2 h before admission. On examination she was comatose, had ventricular tachycardia and multifocal clonic seizures. Intravenous fluid, per oral activated charcoal, diazepam, lidocaine, and sodium bicarbonate infusion were given. However, there was no response to this therapy, and the patient remained in a deep coma with cardiac arrhythmias and seizures. Hemoperfusion (HP) was performed for 2 h. During this procedure, cardioversion was used six times due to ventricular fibrillation. She had a very good clinical response to HP and no complication was observed. We suggest that HP may be an effective treatment in children with severe amitriptyline intoxication.

Amitriptyline↗

PubMed2003

Outcome in children on chronic peritoneal dialysis.

In this retrospective study, we evaluated the causative factors, outcomes, and complications of therapy in 35 patients (16 girls, 19 boys) started on chronic peritoneal dialysis (CPD) between 1997 and 2002. Average age at initiation of CPD was 9.3 +/- 4.4 years. All patients started on continuous ambulatory peritoneal dialysis (CAPD). Nine patients switched to ambulatory peritoneal dialysis (APD) during the follow-up period. The most common cause leading to end-stage renal disease (ESRD) in the patients was reflux nephropathy (22.9%). The major complication during therapy was peritonitis, with 41 episodes seen in 17 patients (1 episode per 18 patient-months). Of the children on APD, 7 developed 17 episodes of peritonitis (1 episode per 8.3 patient-months); of the children on CAPD, 10 developed 24 peritonitis attacks (1 episode per 24.9 patient-months). The other complications were inguinal hernia in 3 patients, subcutaneous leak in 4 patients, dialysate leak in 2 patients, pericardial effusion in 1 patient, umbilical hernia in 1 patient, hydrothorax in 1 patient, and cuff protrusion in 3 patients. During the follow-up period, 4 patients died owing to sepsis or cardiopulmonary complications. Only 1 patient was transferred to hemodialysis (owing to persistent Candida peritonitis). We think that CPD therapy is a good choice of treatment modality in the management of children with ESRD.

Adolescent↗

PubMed2002

Free choline and phospholipid-bound choline concentrations in serum and dialysate during peritoneal dialysis in children and adults.

OBJECTIVES: This study tested whether continuous ambulatory peritoneal dialysis (CAPD) changes free or phospholipid-bound choline concentrations in serum or peritoneal dialysis fluid of patients with end stage renal disease (ESRD). DESIGN AND METHODS: Serum and dialysate choline and phospholipid-bound choline were measured before, during and after 6 h CAPD. RESULTS: Serum choline concentrations were higher in patients with ESRD compared with age-matched controls. CAPD lowered serum choline concentrations significantly although it did not influence phospholipid-bound choline. Choline accumulated in the dialysate, reaching 28.4 +/- 2.7 microM in children and 18.2 +/- 1.4 microM in adults, during six hours CAPD; phospholipid-bound choline increased to 22.9 +/- 2.5 microM and 10.8 +/- 1.4 microM in children and adults, respectively. The total daily loss of choline into the dialysate was 181 +/- 20 micromoles in children and 260 +/- 18 micromoles in adults. CONCLUSION: CAPD causes a substantial loss of choline into peritoneal dialysates and reduces serum choline concentrations significantly.

Adolescent↗

PubMed2002

Lead exposure and urinary N-acetyl beta D glucosaminidase activity in adolescent workers in auto repair workshops.

PURPOSE: To investigate levels of lead (Pb) exposure and renal tubular damage among adolescent workers in auto repair workshops in Turkey. METHODS: The study was conducted on 39 adolescent workers (mean age: 16.18 +/- 3.19 years) in auto repair workshops (8 autoelectrician, 10 motor repairman, 8 auto painter, 5 turner, 8 bonnet straighter). Thirteen adult employees of battery production in the workshops (mean age: 32.08 +/- 10.94 years) and 29 healthy rural adolescent (mean age: 14.78 +/- 2.68 years) constituted the control groups. The level of blood Pb was investigated by an atomic absorption spectrophotometer and urinary N-acetyl beta- D glucosaminidase (NAG) activity was measured by a colorimetric method. Mann-Whitney U test was performed to examine group differences. RESULTS: All subjects and controls had normal blood urea, creatinine, uric acid, sodium, potassium levels, normal routine urine examination and tubular phosphorus reabsorption. Blood Pb levels in auto repair workers (8.13 +/- 7.41 mug/dL) were significantly higher than the rural control group (3.49 +/- 1.39 mug/dL) but lower than the battery workers (25.27 +/- 9.82 mug/dL). Urinary NAG (U/gr creatinine) (4.71 +/- 2.11) was lower than the battery workers (7.39 +/- 4.37), however significantly higher than the normal control group (3.07 +/- 1.20). In addition, auto painters had higher levels of Pb exposure and urinary NAG activity than the other workers (p <.05). CONCLUSION: Chronic low dose Pb exposure was found to cause renal tubular injury in children workers of auto repair workshops.

Acetylglucosaminidase↗

PubMedDate not supplied

Presentation of a case with Salmonella glomerulonephritis.

Salmonella infection is frequently encountered in childhood, but it is rarely associated with glomerulonephritis. We present in this report a case with Salmonella glomerulonephritis, which is infrequent in children. His general condition was found moderate, and temperature and blood pressure were 38 degrees C and 150/90 mmHg, respectively. The whole blood counts were as follows: white blood cell count 3,800/mm3, hemoglobin 6.3 g/dl and platelet count 240,000/mm3. Serum urea was 140 mg/dl, albumin 2.5 g/dl and complement (C3) 23.6 mg/dl. Both Salmonella type O and Salmonella typhi H were detected positive (1/800 titer). In view of these findings, the case was considered as Salmonella glomerulonephritis; his clinical and laboratory recovery were achieved by supportive therapy.

Child↗