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Biomedical subjects

P A Beckett

Publications and source records attributed to P A Beckett.

8 recordsLinked to original sources

Pharmacotherapy and airway remodelling in asthma?

Over the last few decades attention has largely focused on airway inflammation in asthma, but more recently it has been appreciated that there are important structural airway changes which have been grouped together under the term "airway remodelling". It is only now that questions have been asked about the impact of treatment on these structural changes. This review examines the nature of these structural airway changes, the mechanisms of their generation, their potential consequences, and what is known about the ability of anti-asthma treatments to modulate these changes.

Adrenal Cortex Hormones↗

Similar processing of real- and subjective-contour Poggendorff figures by men and women.

Measures of illusion magnitude for a real-contour and two subjective-contour Poggendorff figures were obtained from 42 men and 42 women. Although magnitudes of illusion differed as a function of figure type, male-female differences in magnitude of illusion did not vary across figures or judgment orders. Also, correlations among the illusions observed for three types of figures did not differ for men and women. These data are consistent with the view that real- and subjective-contour Poggendorff figures evoke similar processing strategies and that sex differences, when observed, are probably the result of differences in cognitive-judgmental strategy rather than differences in the optical and neural properties of the visual system.

Attention↗

Illusion decrement and transfer of illusion decrement in real- and subjective-contour Poggendorff figures.

The reduction in illusion magnitude with visual inspection and the transfer of such illusion decrement to a noninspected figure were examined in real- and subjective-contour Poggendorff figures. For both types of figures, illusion magnitude decreased significantly, and in a similar manner, during a 5-min inspection period. Postinspection tests showed that inspecting either a real- or subjective-contour figure resulted in a reduction in illusion magnitude for the other, noninspected figure. These findings suggest that real- and subjective-contour Poggendorff figures share a similar global organization and are thus probably processed in a similar manner. These characteristics make subjective-contour figures a useful tool for separating illusion-producing mechanisms into structural and strategy components.

Adult↗

Real and subjective contour Poggendorff illusions: no differences based on eye color.

Measures of illusion magnitude for a real contour and two subjective contour Poggendorff figures were obtained from a large number of dark-eyed and light-eyed undergraduates. Illusion magnitude varied as a function of figure type. However, eye color neither had a significant overall effect on illusion magnitude, nor did it interact with the figure-type variable. These data indicate that the presence of intersecting lines is not the basis of the iris-pigmentation effect reported by Coren and Porac.

Adult↗

Development of the third component in prism adaptation: effects of active and passive movement.

Adaptation to prismatically displaced vision was assessed using a factorial design involving active or passive exposure movement, active or passive test movement, and target location. Tests of visual shift, ipsilateral and contralateral proprioceptive shift, and ipsilateral and contralateral target-pointing shift were made at the completion of 6, 12, 24, 48, and 96 exposure trials. During the early stages of adaptation (< 48 exposure trials), changes in ipsilateral target pointing were completely accounted for by the sum of the visual and ipsilateral proprioceptive changes. Following longer exposure durations, evidence of a third component was obtained, but only when exposure and test movements were the same (i.e., active-active and passive-passive conditions). The acquisition of such movement-specific response tendencies was interpreted as indicating that the third component represents a change in a central program or schema, which is responsible for guiding a limb to an externally specified location. Target location had no effect on the presence or magnitude of the third component, and there was no indication that the third component transferred intermanually.

Adaptation, Psychological↗

Individual differences in the visual component of prism adaptation.

The centrality of individual differences in the visual component of perceptual adaptation was examined in a massed-practice-terminal-exposure, prism-viewing paradigm. With positive (adaptive) adjustments in the judgment of the visual straight-ahead, target-pointing aftereffects were found to be equivalent to the sum of the visual and proprioceptive (head-arm) aftereffects. For subjects showing negative visual adjustments to prism exposure, the target-pointing aftereffect was not significantly different from the change in proprioception alone. Implications of these findings for hypotheses concerning the process of perceptual adaptation are discussed.

Awareness↗