PubMed Health⌕ Search

Biomedical subjects

P A Bick

Publications and source records attributed to P A Bick.

14 recordsLinked to original sources
PubMed1990

Results of a double-blind placebo controlled trial of a new serotonin uptake inhibitor, sertraline, in the treatment of obsessive-compulsive disorder.

Eighty-seven patients with a DSM-III diagnosis of obsessive-compulsive disorder (OCD) without depression were entered into a double-blind, placebo-controlled study of the efficacy of sertraline, a new serotonin uptake inhibitor. After a 1-week washout period, patients were randomly assigned to receive either placebo or sertraline. After a 2-week titration period in which the once-daily sertraline dose was increased from 50 mg/day to a maximum of 200 mg/day, dosage was maintained until the end of the eighth week, then patients were titrated off medication over the next 2 weeks. Efficacy was measured by the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS), NIMH General Obsessive-Compulsive Scale, Maudsley Obsessive Compulsive (MOC) Inventory, and Clinical Global Impressions (CGI) Severity and Improvement scales. Results on the MOC Inventory showed trends in favor of active drug that were not statistically significant compared with placebo. Results of the Y-BOCS total score, the NIMH score, and the global severity and improvement scores demonstrated a statistically significant superiority of sertraline compared with placebo.

1-Naphthylamine↗
PubMed1987

Auditory hallucinations and subvocal speech in schizophrenic patients.

Fourteen of 18 hallucinating schizophrenic patients reported that the voices they heard went away when they undertook a maneuver that precluded subvocalization. The same applied to 18 of 21 normal subjects who hallucinated under the influence of hypnotic suggestion. Control maneuvers had no such effect. The authors suggest that auditory hallucinations may be projections of schizophrenic patients' verbal thoughts, subvocalized due to deficient cerebral cortical inhibition.

Adaptation, Psychological↗
PubMed1986

A comprehensive study of chronic schizophrenic patients. II: Biological, neuropsychological, and clinical correlates of CT abnormality.

There are numerous reports of lateral cerebral ventricle enlargement on computed tomography (CT) in schizophrenics, but the significance and its relationship to traditional notions of organicity remain unclear. Therefore we studied a subgroup of chronic schizophrenics who had lateral ventriculomegaly (and also cortical hyperdensity) on a battery of relevant biological, neuro-psychological, and clinical parameters such as electroencephalogram (EEG), platelet monoamine oxidase (MAO) and serum dopamine-beta-hydroxylase (DBH) activity, the Halstead Reitan Neuropsychological Battery (HRB), premorbid personality adjustment, drug response, positive and negative symptoms, employment history, and family history. Our findings support the notion that there is an "organic" subgroup of schizophrenia that has 1) CT structural abnormalities such as lateral ventricle enlargement and cortical hyperdensity; and cerebral dysfunction or deficits as evidenced by 2) an increased incidence of abnormal EEGs and also 3) greater impairment on neuropsychological tests. The biochemical measures, platelet MAO and serum DBH activity, nor any of the clinical measures could differentiate between the subgroups. The implications of these findings for the subtyping of schizophrenia are discussed.

Adult↗
PubMed1986

Seasonal major affective disorder.

A seasonal affective disorder characterized by mild affective symptoms has recently been described. The author presents four cases of severe major affective disorder with a seasonal pattern and discusses the clinical relevance of seasonality.

Adult↗
PubMed1984

The syndrome of intermetamorphosis.

The author presents a case of the intermetamorphosis syndrome, a rare variant of Capgras' syndrome involving a patient's perceiving that an individual has been transformed both psychologically and physically into another person.

Adult↗
PubMed1984

Two case reports of trazodone-induced mania.

Two unipolar depressed patients developed manic symptoms when treated with trazodone. The symptoms resolved when the drug was discontinued. The authors believe these to be the first two cases of such a reaction reported in the literature.

Adult↗
PubMed1983

Obsessive-compulsive behavior associated with dexamethasone treatment.

A patient treated with dexamethasone for cerebral edema secondary to a cerebral tumor developed acute obsessive-compulsive behavior. Discontinuation of dexamethasone was accompanied by a rapid subsidence of this behavior, suggesting a causal association. This appears to be the first such report.

Brain Edema↗
PubMed1983

Physiological and psychological correlates of motion sickness.

Motion sickness (MS)has been inconclusively associated with personality and physical vestibular functioning in both males and females. The present work consisted of six tests: test of field dependency; pure balance test; motion sickness questionnaire; body steadiness test; primary suggestibility test; resistance to disturbance test. In addition the EPI was completed by a proportion of subjects. Male and female data for the 15 male and 15 female subjects in an age range 20 to 30 years, obtained from within Bedford College, University of London, were factor analysed separately. The results show that, firstly, field dependence, as understood by Witkin, is not associated with any of the factor and correlated significantly (r = 0.83, P less than 0.001; two-tailed test). The same correlation in women was not significantly (r = 0.17). For females, MS and neuroticism appeared on the same factor and correlated significantly (r = 0.62, P less than 0.05; two tailed test). The same correlation in men was not significant (r = 0.06). This suggests that MS in females is associated primarily with neuroticism, whereas in males it is associated with vestibular disturbance thresholds.

Adult↗
PubMed1982

Hypnosis.

Explore the source record for details and available documents.

Adult↗