Rhabdomyolysis and hypophosphatemia.
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Acute Kidney Injury↗
Biomedical subjects
P A Ellinas
Publications and source records attributed to P A Ellinas.
Symptomatic hyponatremia associated with psychosis, medications, and smoking.
Over a 3-year period, 15 patients with severe hyponatremia were referred to our emergency room from a nearby psychiatric institution. This article reports on 36 episodes of symptomatic hyponatremia in those 15 patients. All but two of the patients were receiving antipsychotic medications; one patient was taking a nonsteroidal anti-inflammatory drug, and one patient was taking an oral hypoglycemic agent. Thirteen patients were chronic schizophrenics, one had a bipolar depressive disorder with psychotic features, and one patient had no psychiatric disorder. Patients presented with seizures, change in mental status, and vegetative symptoms (nausea, vomiting, and diarrhea) associated with hyponatremia and water intoxication. Exacerbation of the patients' underlying illness, psychogenic polydipsia, compulsive smoking, alcoholic cirrhosis, drug abuse, and neuroleptic and other medications are thought to be the major causes of acute hyponatremia in these patients.
Adult↗
Rhabdomyolysis: report of eleven cases.
This article reports the results of a retrospective study of 11 patients with rhabdomyolysis-induced acute renal failure. All patients had multiple risk factors for rhabdomyolysis, the most common of which were alcoholism, illicit drug abuse, compression, and trauma. Patients with combined alcohol/illicit drug abuse had more severe electrolyte imbalances than patients without alcohol/illicit drug abuse. Myoglobinuria was detected in only half the patients despite rhabdomyolysis and urine "hematest" positivity. The serum creatine phosphokinase level was elevated in all of the patients, which is a good marker for rhabdomyolysis. Rhabdomyolysis is a relatively common disorder in municipal hospitals. Routine serum creatine phosphokinase levels should be checked on patients at risk, especially alcoholics, illicit drug abusers, and older patients.
Acute Kidney Injury↗
Pott's disease in urban populations. A report of five cases and a review of the literature.
Five patients were treated at the Queens Hospital Center between 1987 and 1989 for tuberculosis of the spine. All were members of low socioeconomic status minority groups: four were black and one was Asian. Three were intravenous drug abusers and were positive for human immunodeficiency virus (HIV), one was homeless and suffering from alcoholism, and one had just arrived in the United States from a region in Asia endemic for tuberculosis. All three HIV positive patients had negative tuberculin skin test results, had no radiographic signs of pulmonary involvement, and were anemic on presentation; one of them had a bone marrow biopsy that was positive for acid-fast bacilli. Since there may be a prolonged delay without significant radiographic findings, a high index of suspicion is necessary to make the diagnosis of tuberculosis of the spine.
Adult↗
Self-assembly of porphyrins on nucleic acid templates.
The cis and trans isomers of dicationic bis(4-N-methylpyridyl)diphenylporphine show a much greater tendency to aggregate than similar tetracationic porphyrins. Upon binding to nucleic acids these aggregating dicationic porphyrins form long-range structures on the polymer template giving intense circular dichroism signals whose profile reports the helical sense of the DNA.
Chemical Phenomena↗