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Biomedical subjects

P A Farrands

Publications and source records attributed to P A Farrands.

24 records · Page 2Linked to original sources
PubMed1983

Localisation of human osteosarcoma by antitumour monoclonal antibody.

Immunoscintigraphy using radioisotope-labelled monoclonal antibody prepared against osteosarcoma 791T cells was used to detect a primary osteosarcoma. The eight-centimetre tumour was detected using rectilinear scintigraphy of 131I-labelled antibodies. Image enhancement was achieved by subtraction of blood-pool radioactivity labelled with technetium-99m. The ratio of tumour to non-tumour uptake of radioactivity (5:1) suggested that antibody targeting of therapeutic agents is feasible.

Adolescent↗
PubMed1983

Accuracy of occult blood tests over a six-day period.

The false negative rate of the stabilized guaiac faecal occult blood tests, Fecatest and Haemoccult, was determined in 61 patients with known colorectal cancer. When subjects tested their stools over three days, 9.7% of the Fecatest slides and 27.8% of the Haemoccult slides were negative (p less than 0.02). Extending the number of days of testing from three to six reduced the false negative rate of Fecatest to 4.8% and Haemoccult to 9.7% (p less than 0.05). There was no significant difference between the false negative rate of Fecatest and Haemoccult test when subjects performed six-day testing. Haemoccult false negative results occurred mainly in patients with well differentiated left sided carcinomas.

Adult↗
PubMed1982

Radioimmunodetection of human colorectal cancers by an anti-tumour monoclonal antibody.

In 10 out of 11 patients with colorectal cancer radiolabelled antitumour monoclonal antibody (791T/36) was localised to the tumour. The mean tumour to non-tumour uptake ratio of antibody demonstrated by imaging with a gamma camera was 4.4/1 after subtraction of background radioactivity. The antibody did not localise in one patient who had received radiotherapy to his tumour two weeks previously. In 5 patients with primary neoplasms localisation of the antibody was confirmed by further imaging of the resected specimens and in-vitro radioactivity counting of the tumour and comparison with the activity in adjacent normal colon.

Adult↗