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Biomedical subjects

P A Kovalenko

Publications and source records attributed to P A Kovalenko.

At least 19 recordsLinked to original sources
PubMed2005

[The predictors of ischemic stroke in cerebral atherosclerosis and ischemic heart disease].

The complex medical examination was performed in 145 patients admitted to the neurological department with initial diagnosis: "ischemic stroke". We compared anamnesis, clinical symptoms, laboratory and instrumental findings in the patients with verified ischemic stroke and in those without stroke. The significant clinical predictors of ischemic stroke were the following: arterial hypertension (> 165/ 95 mm Hg) age 64 years and older, circulatory insufficiency, diabetes, atrial fibrillation, lower extremity obliterating atherosclerosis, pneumosclerosis and pulmonary emphizema.

Adult↗
PubMed2004

[Peculiarities of nervous system lesions in patients with multiple myeloma].

Multiple myeloma (MM) is B-cellular lymphoproliferative disease. We studied 174 patients aged 33-84 with established diagnosis of MM. Among the persons included into analyzed cohort the data about the presence of polyneuropathy at the moment of MM verification were available in 72 (41.4%) persons. Spinal cord involvement due to the various pathogenetic reasons was revealed in 24 (13.8 +/- 2.6%) patients. Compressional alteration was observed in 19 cases and in 5 patients the spinal cord involvement had uncompressional genesis. The connection between the peripheral polyneuropathy and the unfavourable prognosis in MM patients was statistically insignificant. In the patients with spinal cord prelum the probability of lethal outcome within 1 month was 0.26. It is 10 times more than in patients suffering only from peripheral polyneuropathy. Thus polyneuropathy in MM patients occurs in 41.4 +/- 3.7% cases and more often during the III stage of disease. There is a distinct interrelation between the nervous trunk involvement and disease severity. In the structure of polyneuropathy the sensorimotor variant (76.4 +/- 5.0%) prevails. According to our data the spinal cord involvement occurs in 13.8 +/- 2.6% cases.

Adult↗
PubMed2002

[Neurological complications of infectious endocarditis].

Of 204 patients with infectious endocarditis (IE) treated in the hospital in 1980-2000, 43(21.2%) developed neurological complications. These were: ischemic stroke (72.1%), hemorrhagic stroke (9.3%), both (7%), abscess and subarachnoidal hemorrhage (2.3% for each), meningitis (7%), toxic encephalopathy (11.6%). Neurological complications of IE arose prior to treatment and within the first week of antibacterial therapy in 63% cases, more frequently in the left carotid territory. Neurological complications in IE debute manifested acutely, pareses were more frequent than paralyses, with elevated temperature, low hemoglobin and red cell levels, leukocytosis. MRT detected 8 +/- 4.6 foci in the brain, CT--2 +/- 1.1, on the average. Lethality of IE patients with neurological complications reached 58.1% and was significantly higher than in those without such complications (14.9%, p < 0.001). Overall acturial survival 1 year after the discharge from the hospital was 94.4%, 5-year survival--61.1%, 10-year survival--11%.

Adolescent↗
PubMed2001

Association between allergy and anxiety disorders in youth.

OBJECTIVE: Studies have documented associations between anxiety disorders and allergy in adults, but these associations have not been studied extensively in children. The objective of this study is to examine the associations between allergy and six anxiety disorders (AD) in youth. METHOD: This is a data analysis of two epidemiologic-services studies: (i) alternative service use patterns of youth with serious emotional disturbance (n = 936), and (ii) methods for the epidemiology of child and adolescent mental disorders (n = 1285). Child psychiatric diagnoses were measured by the diagnostic interview schedule for children. Allergy was assessed by the service utilization and risk factors interview. RESULTS: Among ADs, the strongest association found was between allergy and panic disorder (adjusted odds ratio 5.0; p < or = 0.001). Associations of allergy and the other ADs do not seem to be clinically significant. CONCLUSIONS: Findings suggest that in some patients panic disorder may be associated with hypersensitivity of immune system. Panic disorder should be considered in anxious children reporting allergy when no organic cause of allergy is found, and likewise allergy should considered in children with panic disorder.

Adolescent↗
PubMed2000

Seasonal variations in internalizing, externalizing, and substance use disorders in youth.

Seasonal variations were assessed in symptoms of internalizing (anxiety and mood), externalizing (attention-deficit/hyperactivity and oppositional defiant disorders), and substance use disorders in youth. This study is based on secondary data analysis of two NIMH-funded epidemiologic-services studies: (a) Alternative Service Use Patterns by Youth with Serious Emotional Disturbance (N=936, ages 9-17); and (b) Methods for the Epidemiology of Child and Adolescent Mental Disorders (N=1285, ages 9-17). Child psychiatric diagnoses were measured by the Diagnostic Interview Schedule for Children. Variables that indicate site of the interview and service system, as well as age, gender, and ethnicity, were used as covariates. Significant annual variations were found in symptom counts of overanxious disorder, obsessive-compulsive disorder, separation anxiety disorder, social phobia, and major depressive disorder, with the estimated nadir in August-October. There may be weak seasonal variations in attention-deficit/hyperactivity disorder with estimated nadir in August, oppositional defiant disorder with estimated nadir in August-September, and marijuana use with estimated zenith in August-September. Significant seasonality in alcohol, other substance use, agoraphobia, and panic disorder was not found. There may be an instrument-specific bias in estimated nadir. Real nadirs may be up to 3 months prior to the estimated nadirs specified above. Findings suggest that seasonality in symptoms should be considered when assessment instruments of childhood psychiatric disorders are developed, as well as when epidemiological and clinical data are collected and analyzed.

Adolescent↗
PubMed1997

[The role of arterial hypertension in the occurrence of strokes at a young age].

The analysis of insult occurrence in patients at the age under 45 years, caused by blood hypertension, shows, that they make 30.1% from common number of insult in 166 young people, treated in the neurological and other departments of Burdenko Main Military Clinical Hospital in 1989-1996. On occasion of ischemic insult were treated 37 patients, hemorrhagic--13. The reason of insults was "soft" blood hypertension: in 51.4%--at ischemic insult and in 30.1%--hemorrhagic. The authors consider, that the main direction of prophylaxis of insult is active revealing and adequate treatment of the patients with blood, including "soft" hypertension, use of hypotensive preparations and some non-medicative methods of treatment.

Adolescent↗