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Biomedical subjects

P A Lamba

Publications and source records attributed to P A Lamba.

At least 19 recordsLinked to original sources
PubMed1993

Serum sialic acid levels in patients with sympathetic ophthalmitis.

Serum sialic acid levels were measured in 16 patients with sympathetic ophthalmitis, 36 with neglected traumatic uveitis following penetrating injury and 40 healthy subjects. There was no significant alteration of its level in patients with traumatic uveitis. However, its level was significantly elevated in patients with sympathetic ophthalmitis. It was high even in the early stage of the disease. It decreased significantly at the remission stage. It is proposed that measurement of sialic acid level in serum can be used as a diagnostic aid when the diagnosis of sympathetic ophthalmitis remains doubtful on clinical grounds. The extent of rise in its level may be considered a good parameter of the degree of severity of sympathetic ophthalmitis. It may also act as a useful tool to evaluate the drug efficacy in this disease.

Adolescent↗
PubMed1987

Factors influencing corneal involvement in leprosy.

Corneal involvement in leprosy is known to be influenced by factors such as lagophthalmos, ectropion, and corneal anesthesia. In the present study conducted on 400 eyes of leprosy patients, observations were made on tear film abnormalities, and their relation to the above-mentioned factors was analyzed. The abnormality of tear film breakup time (BKUT) was found to be clinically more significant (47.2%) than a Schirmer's test alone (24.5%), and this finding was of greater significance in the lepromatous form of leprosy. An abnormal BKUT reflects a decreased mucin secretion by the conjunctival goblet cells. Tear film abnormalities in association with lagophthalmos, corneal anesthesia, concomitant ocular diseases, and environmental factors such as high relative humidity have been identified as factors contributing to corneal involvement in leprosy in India. It is not surprising that with so many mechanisms of corneal involvement the clinical manifestations are diverse, and all forms of pathological changes may contribute to corneal morbidity.

Cornea↗
PubMed1987

Evaluation of precorneal tear film in leprosy.

The present study analyses the precorneal teat film using schirmer's test and tear film breakup time (BKUT) in 400 eyes of patients with various types of leprosy. An abnormal tear film BKUT (47.2%) was observed to be much more informative in the present series than the study of schirmer's test alone (25.4%). In patients with lagophthalmos an abnormal tear film BKUT (70%) was higher as compared to an abnormal schirmer's test (40%); while in cases of lagophthalmos with ectropion an abnormal schirmer's test was seen less frequently (26.8%) than in cases of lagophthalmos without ectropion (58.3%). This implied an increase in the aqueous content of the tear film in cases of lagophthalmos with ectropion on the basis of an associated chronic conjunctivitis. Lagophthalmos and ectropion have been identified as additional factors contributing to corneal morbidity. There was a statistically significant difference in the tear film abnormality in different types of leprosy, the maximal difference being in the lepromatous variety.

Humans↗
PubMed1987

Argon laser iridotomy in angle closure glaucoma.

Argon laser iridotomy was successfully performed in 30 eyes of glaucoma patients. A modified two stage procedure has been described to achieve a successful iridotomy in pigmented eyes. At the chosen site of laser iridotomy, partial thickness burns were applied in the first stage followed by a penetrating burns in the second stage. This minimised the complications associated with laser iridotomy and decreased the incidence of subsequent closure. At the end of 6 months follow up the success rate was 93.3 percent.

Adult↗
PubMed1986

Immunoassay of tear lysozyme in acute adenovirus conjunctivitis.

The tear lysozyme levels were measured by immunoassay in 92 healthy subjects and 98 patients with acute adenovirus conjunctivitis. They were found to be significantly decreased during the acute phase of the disease. The extent of this decline in the tear lysozyme level was correlated with increased severity of disease. There was no significant difference in the tear lysozyme level in viral isolation-positive and isolation-negative patients. The tear lysozyme level showed return to normal levels with clinical improvement.

Acute Disease↗
PubMed1985

Xenon arc photocoagulation for treatment of subluxation of lens.

In the treatment of congenital or acquired subluxation of the lens a conservative approach to reposition the pupil in front of the aphakic area by the use of the xenon arc photocoagulator is emphasised. The management of two cases of subluxation is discussed in detail and the results evaluated. The ease of repositioning the pupil by means of iris photocoagulation and the absence of surgical complications are indications for the use of this non-invasive procedure in the treatment of subluxated lenses.

Adult↗
PubMed1983

Central serous retinopathy in leprosy.

The involvement of fundus is rare in leprosy. More so fundus lesions, if any, are not very well visualized because of anterior segment lesions and the pupillary adhesions. A case of central serous retinopathy is recorded in association with progressive lepra reaction (type II) in a case of leprosy.

Adult↗
PubMed1983

Ocular leprosy - a new perspective.

The classification of ocular lesions in leprosy into academic and PST lesions clears away much of the confusion engendered by the wide disparity in the reported incidences. It also enables to project confidently the level of ocular morbidity in a given leprosy population with more precision. Based on the observation in the study approximately 1.5 million leprosy patients are expected to be affected with potentially sight threatening lesions. Measures to be undertaken to prevent this morbidity and visual impairment in this vulnerable group can be better worked up. The incidence of blindness on account of leprosy is reported to be 2.6 percent.

Blindness↗