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Biomedical subjects

P A Millac

Publications and source records attributed to P A Millac.

8 recordsLinked to original sources
PubMed1991

The apomorphine test in parkinsonian syndromes.

The dopamine receptor agonist apomorphine has been used successfully to treat on-off swings in Parkinson's disease. Its value as a predictor of dopa responsiveness in idiopathic Parkinson's disease (IPD) was assessed and its potential role in differentiating IPD from the Parkinsonian plus syndromes (PPS) of multisystem atrophy, progressive supranuclear palsy and olivopontocerebellar atrophy was investigated. The response to an injection of apomorphine was observed in 20 patients with IPD and eight with PPS after being off levodopa for 12 hours. Patients were reassessed after taking levodopa for one month. Nineteen of the 20 patients (95%) with IPD showed a positive response to apomorphine and 18 (90%) to oral levodopa. In the PPS group, two patients (25%) responded to the apomorphine injection but not to oral levodopa. Apomorphine produced severe drowsiness in the PPS patients. It is suggested that the test can predict dopa responsiveness in IPD and may be of help in confirming a doubtful diagnosis. It has potential value in differentiating IPD from PPS.

Aged↗
PubMed1990

Multiple sclerosis associated with water intoxication.

We present a case of well documented multiple sclerosis which presented with the syndrome of inappropriate antidiuretic hormone secretion, following an exacerbation of the disease. This is a poorly documented association.

Humans↗
PubMed1990

Multiple sclerosis associated with trismus.

This report describes the case history of a middle-aged lady who presented with symptoms and signs over one year leading to a diagnosis of multiple sclerosis. During one of her relapses, she developed trismus--an association that has not been described before in multiple sclerosis.

Female↗
PubMed1981

Tuberculous meningitis in Asian patients.

17 cases of tuberculous meningitis were seen in Leicester hospitals over a 5 year period; 15 of the patients were Asian. Treatment had often been delayed because presentation of the disease was non-specific and the cereobrospinal fluid findings were atypical. The average interval between the onset of symptoms and admission to hospital was 2 weeks (the shortest period was 5 days). Of the 10 patients admitted with disturbance of consciousness 5 died, whereas all 7 who were alert on admission survived. It is essential to exclude tuberculous meningitis in any Asian patient with a persistent febrile illness even if meningism is not evident, since patients who progress to the later stages of the disease often die or are left disabled.

Adolescent↗