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Biomedical subjects

P A Mullen

Publications and source records attributed to P A Mullen.

At least 19 recordsLinked to original sources
PubMed1989

Slaughterhouses.

Explore the source record for details and available documents.

Abattoirs↗
PubMed1979

An investigation of the toxicity of 1alpha-hydroxycholecalciferol to calves.

Two calves were treated with 15 micrograms/kg body weight of 1alpha-hydroxycholecalciferol by intramuscular injection on four occasions at seven-day intervals. Anorexia and reduced water consumption persisted for 48 h after each treatment. No clinical signs of iridocyclitis or any other lesions of the eyes were present at any time either macroscopically or microscopically. After the first treatment serum GOT and GD activities increased, serum AP activity fell, serum concentrations of calcium and inorganic phosphate increased, and magnesium concentrations decreased. The reduced serum magnesium concentrations and increased calcium and inorganic phosphate concentrations were maintained for the duration of the experiment, but there was no evidence of a cumulative effect of successive treatments. Blood urea concentrations increased after the third treatment. The gross pathology at post mortem examination was similar to that reported after vitamin D3 supplementation.

Animals↗
PubMed1978

Clinical and metabolic consequences to cattle of rumen overdosing with di-ureido iso-butane (DUIB).

Di-ureido iso-butane (DUIB) was overdosed on three occasions to two year-old bullocks, under experimental conditions. Six g/kg live weight of DUIB was mixed manually into the rumen contents formed by a predominantly hay diet (10 kg) with added concentrates (2 kg). Marked clinical signs were observed for 72 h before recovery. Food and water intake were interrupted and a smell of ammonia saturated the accommodation. Blood concentrations of urea-nitrogen increased, while glucose fell; a metabolic alkalosis was present. Rumen VFA concentrations fell, but without altering the proportions of the individual acids present, pH increased, urea-nitrogen and ammonia-nitrogen concentrations fluctuated markedly. The pH of duodenal contents increased. Clinical recovery appeared complete after six days with biochemical homeostasis nearly restored.

Ammonia↗
PubMed1977

Milk fever: a case against polypharmacy solutions.

One hundred and thirty four cases of hypocalcaemia (parturient paresis) between April and Jul 1976 from 72 herds in the UK and Eire were used to compare the response to intravenous treatments with one of three solutions containing calcium salts. Two solutions contained 8 g calcium, one with added magnesium (1.03 g), a third solution contained 6.2 g calcium. The biochemical response obtained 24 hours after successful treatment from all solutions was similar. The clinical response with both 8 g calcium solutions was similar and significantly superior to that obtained with 6.2 g calcium (P less than 0.02 greater than 0.01). More cases (44 per cent) relapsed after treatment with 6.2 g calcium. There was no evidence that the added magnesium to the calcium solution improved the clinical response of parturient paresis cases in this spring claving season, as had been suggested previously. The herds providing these 134 cases had recorded an incidence of 8.04 per cent for parturient paresis in 1975.

Animals↗
PubMed1977

Stimulus picture identification in articulation testing.

The present study was designed to compare the percent of correct initial identification of stimulus pictures on the Goldman-Fristoe Test of Articulation with the percent correct identification on the Arizona Articulation Proficiency Scale. This study was undertaken in an effort to clarify the results of a previous study in which the Goldman-Fristoe, a test designed to reduce time of administration, took significantly longer administration time than the Arizona, a traditional type of articulation test. Twenty normal-speaking and 20 articulation-defective children served as subjects for the study. Each subject was administered those portions of the articulation tests which included stimulus pictures used to elicit production of the consonants and consonant blends. Each child's initial identification of the stimulus picture was recorded. Results indicated that the Arizona test elicits significantly (p less than 0.001) more correct initial stimulus picture identifications thandoes the Goldman-Fristoe test.

Child↗
PubMed1975

Clinical and biochemical responses to the treatment of milk fever.

One hundred and eighty-six cases of milk fever in 80 herds spread over five counties were used to compare treatment with 8g calcium plus 500 mg magnesium in aspartate with the conventional 12-36g calcium as borogluconate. The data obtained from both the herds and their individual cases show that the treatments gave broadly similar results, and a single intravenous treatment cured 74-7 per cent of cases. It appeared that milk fever was not likely to recur with each succeeding parturition. No breed susceptibility was recognised. No correlation was found between the severity of the clinical signs and the inorganic phosphate concentrations. An incidence of milk fever of 8-79 per cent was recorded.

Animals↗
PubMed1975

Atrophic rhinitis of pigs: abattoir studies.

The snouts of 2701 pork, bacon and heavy pigs killed at five abattoirs in England and Scotland during March to July 1974 were examined for evidence of atrophic rhinitis. Lesions were graded 1 to 5 according to severity. Suspicious lesions were present in 75-7 per cent of the sample. There was obvious atrophy of the turbinates in 44-7 per cent (grade 2 to 5) and severe atrophy in 17-5 per cent (grades 3 to 5). Foreign bodies were found in or between the posterior cheek teeth of 5-3 per cent of the sample. There was frequently an associated gingivitis. Other lesions seen included black discolouration of the teeth, severe tooth wear and osteoarthrosis of the temporomandibular joint. It was concluded that the incidence of atrophic rhinitis could have increased markedly since the last survey of the United Kingdom was undertaken in 1956/57 and some form of disease-monitoring service was urgently needed.

Abattoirs↗