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Biomedical subjects

P A Randall

Publications and source records attributed to P A Randall.

7 recordsLinked to original sources
PubMed1979

Failure of prostaglandins E1 and E2 to alter canine gastric mucosal cyclic nucleotides.

The action of prostaglandins and indomethacin on gastric mucosal cyclic nucleotide concentrations was evaluated in 18 anesthetized mongrel dogs. Prostaglandins E1 (PGE1) and E2 (PGE2) (25 microgram/kg bolus, then 2 micrograms/kg/min) were administered both intravenously (4 experiments; femoral vein) and directly into the gastric mucosal circulation (10 experiments; superior mesenteric artery). The possible synergistic effect of pre-treatment and continuous arterial infusion of indomethacin (5 mg/kg bolus for 5 min, then 5 mg/min), a prostaglandin synthetase inhibitor, with PGE2 was studied in 4 experiments. Antral and fundic mucosa were biopsied and measured by radioimmunoassay for cyclic nucleotides. Doses of PGE1 and PGE2 which inhibited histamine-stimulated canine gastric acid secretion did not significantly alter antral or fundic mucosal cyclic nucleotide concentrations. Concomitant infusion of PGE2 with indomethacin did not potentiate the mucosal nucleotide response compared to PGE2 alone. These studies fail to implicate cyclic nucleotides as mediators of the inhibitory acid response response induced by PGE1 or PGE2 in intact dog stomach.

Animals↗
PubMed1979

Arteria magna revisited.

Arteria magna has been described pathologically in the literature as a peculiar and unique form of atherosclerosis. The authors offer an alternative hypothesis, based on results of angiographic studies with pathologic correlation in 18 patients with arteria magna. The findings indicate that this vascular entity might be more accurately described as a loss of the medial elastica with subsequent vessel enlargement both in length and diameter.

Adult↗
PubMed1977

Involvement of an aberrant right subclavian artery in dissection of the thoracic aorta: diagnostic and therapeutic implications.

There have been few reports of an aberrant right subclavian artery in patients with aortic dissection. The diagnostic and therapeutic implications of the association of these two abnormalities are important and potentially ominous. Two patients with extensive type III dissections of the thoracic and abdominal aorta are described. In one patient, extension of the dissection into the aberrant right subclavian artery led to eventual exsanguination into the esophagus. In the second patient, cross-clamping of the abdominal aorta proximal to the left subclavian artery at surgery resulted in complete cutoff of blood supply to both vertebral arteries and the patient's subsequent demise.

Aortic Dissection↗
PubMed1977

Hormone-mediated oviductal influence on mouse embryo development.

This study presents evidence that estradiol, mediated through oviduct fluid, may adversely affect the development of early embryos. Two-cell mouse embryos were cultured in Whitten-Biggers medium with or without 0.2 to 20 microgram/ml of estradiol or progesterone or in mouse oviduct fluid from donors treated with estradiol or estradiol and progesterone. Embryos cultured in fluid from estrogen-dominated donors were significantly less able to develop to morula (65%) or blastocyst (14%) than were those cultured in either Whitten-Biggers medium (91% and 41%) or progesterone-dominated fluid (87% and 36%). Transfer of cultured morulae and blastocysts to uteri of pseudopregnant recipients resulted in 2/3, 4/6, and 0/7 recipients' becoming pregnant for control, progesterone-dominated, and estrogen-dominated, respectively. When estradiol or progesterone was added directly to the control medium, no inhibitory effects were observed at levels higher than those found physiologically in plasma. Protein concentration and osmolalities for representative samples of oviduct fluid were 5.2 mg/ml and 329 mOsM for estrogen-dominated fluid and 1.6 mg/ml and 339 mOsM for progesterone-dominated fluid.

Animals↗