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Biomedical subjects

P A Reder

Publications and source records attributed to P A Reder.

3 recordsLinked to original sources

Use of magnetic resonance imaging and magnetic resonance angiography in diagnosis of sigmoid sinus thrombosis.

Magnetic resonance angiography is an established radiologic technique which is rapidly becoming useful in imaging the head and neck. Currently, this imaging modality is important in the diagnosis of sigmoid sinus thrombosis caused by otologic disease. Since the introduction of antibiotic therapy, the percentage of deaths attributed to intracranial complications from otitic disease has decreased from 2.5 to approximately 0.25% of documented deaths. Also, the incidence of sinus thrombosis within this group has decreased, but it is still a serious and potentially lethal condition. Sinus thrombosis is suspected clinically when mastoid disease progresses, with picket fence fever pattern, chills, headaches and signs of papilledema. Definitive diagnosis is necessary before surgical treatment. The Queckenstedt test is unreliable, computed tomography is better suited for demonstrating thrombosis of the sagittal sinus rather than the sigmoid sinus, and conventional angiography (although it provides excellent visualization) has the hazard of ionizing radiation and requires vessel puncture and the use of intraarterial contrast agents. We present two cases of thrombosis of the sigmoid sinus as an intracranial otologic complication which were diagnosed definitively with magnetic resonance imaging and magnetic resonance angiography. The combination of magnetic resonance imaging, which showed the thrombosis displaying abnormal signal intensity, and magnetic resonance angiography, which demonstrated the absence of flow in the sinus, was an ideal diagnostic tool. For both patients, treatment consisted of mastoidectomy, sigmoid sinus decompression and antibiotics.

Adolescent↗

Blastomycosis in otolaryngology: review of a large series.

Blastomycosis is a fungal disease whose signs, symptoms, and roentgenographic findings may suggest pneumonia, cancer, tuberculosis, or other fungal infections. Blastomycosis has a variable clinical course; it primarily affects the lower respiratory tract, although extrapulmonary manifestations are common. To determine the frequency of head and neck manifestations, we reviewed the records of patients with blastomycosis seen at the Mayo Clinic from 1960 to 1990 and found that involvement of the skin and mucosal surfaces, including the larynx, was common. Gross and histopathologic features of the lesions often resemble those of well-differentiated squamous cell carcinoma; thus, overly aggressive therapy may be mistakenly instituted. The clinical features, morphologic findings, and diagnosis of blastomycosis are discussed, and the importance of obtaining and handling specimens correctly is emphasized.

Blastomycosis↗

A method for controlled mechanical stimulation of single semicircular canals.

In the present technical report, we describe a method of mechanical stimulation for single semicircular canals that is reproducible, sensitive, and discrete. The mechanical stimulator is capable of delivering reliable controlled stimuli of different waveforms over a wide frequency range that produce endolymph movements and consequent cupula deflections without motion being imparted to the animal. The results of electrophysiological experiments where the responses from pigeon (Columba livia) single horizontal semicircular canal afferent fibers produced by mechanical stimulation across a broad frequency bandwidth are reported. Comparisons between afferent fiber responses elicited by natural yaw rotation and mechanical stimulation were conducted, with the results indicating that the two stimulation methods produced responses from the same afferent unit that could be equated in magnitude. In addition, results are described from several control experiments that were conducted in order to determine the efficacy of the mechanical stimulation technique.

Acoustic Stimulation↗