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Biomedical subjects

P A van Damme

Publications and source records attributed to P A van Damme.

At least 19 recordsLinked to original sources
PubMed2002

The synergistic value of focus score and IgA% score of sublabial salivary gland biopsy for the accuracy of the diagnosis of Sjögren's syndrome: a 10-year comparison.

OBJECTIVE: Increasing the accuracy of the diagnosis of Sjögren's syndrome (SS) by placing emphasis on objective findings such as the presence of anti-Ro and anti-La autoantibodies and abnormal salivary gland tissue (SGT) histology is a current issue. In order to obtain optimal disease sensitivity and specificity of SGT findings, histological and immunohistological SGT examinations were compared. The first describes the extent of the lymphocytic infiltrate as a focus score (LFS), whereas the latter describes the composition of the infiltrate as a percentage of IgA-containing plasma cells (IgA%). METHODS: Both the LFS and IgA% score were assessed in 279 SGT biopsies taken from patients with symptoms suggestive of SS. In case histological conclusions did not match immunohistological conclusions patients were assigned to so-called mismatch groups. Patients in the mismatch groups were further classified using objective, serological parameters [rheumatoid factor (RF), anti-Ro, anti-La, anti-nuclear antibodies, gammaglobulin level]. RESULTS: In 249 samples (89%), LFS and IgA% resulted in the same conclusion. Within this group a total of 63 SGT samples (25%) were characteristic for SS showing LFS >1.0 and IgA% <70. In the mismatch groups after serological classification, both false positive as well as false negative scores were observed less frequently for IgA% as compared with LFS (50 vs 75% and 25 vs 50%, respectively). CONCLUSIONS: Additional immunohistological SGT examination provides greater disease sensitivity and specificity than histological SGT examination alone, thereby increasing accuracy of SS diagnosis.

Adult↗
PubMed1997

Three-dimensional morphometric analysis of the effects of subperiosteal palatal soft-tissue expansion in growing cats.

A prospective longitudinal study in 75 growing cats was conducted to evaluate palatal soft-tissue expansion in cleft lip and palate surgery. In 31 cats, palatal scars were induced by simulated Langenbeck surgery at the age of 8 weeks. At the age of 14 weeks, custom-made tissue expanders were inserted in 61 animals. Tissue expansion was performed by weekly inflation in 33 cats (16 without and 17 with scars) for an 8-week period. The remaining 28 cats (14 without and 14 with scars) served as sham groups. A control group was formed by 14 animals (without scars and without tissue expander). The effects of the experimental interventions were evaluated on a series of dental casts during the inflation period and until 8 weeks after removal of the tissue expander. The results indicate that soft-tissue expansion of the palatal mucoperiosteum is feasible. Until 20 weeks of age, no differences were found between both expansion and sham groups. Thereafter, significant soft-tissue surface-area gain was quantified in relation to the base surface and base diameter of the tissue expander. Iatrogenic side-effects of active tissue expansion consisted of significant transversal growth retardation in the anterior part of the bony palate and dentoalveolar structures. After removal of the tissue expanders, some accelerated growth in the tissue-expansion, scarred-tissue group was seen. It is concluded that palatal soft-tissue expansion is possible in growing cats, with and without the presence of palatal scars; however, this technique, like other kinds of palatal surgery, impairs dentomaxillary growth and development.

Age Factors↗
PubMed1996

A modification of the tibial bone-graft-harvesting technique.

A modified method of tibial bone-graft harvesting is presented. A hollow, cylindric, hand-driven instrument is used to harvest the graft at the medial slope of the tibial tuberosity. Satisfactory amounts of autogenous cancellous bone graft are available to bridge osteotomy gaps and facial fractures, fill smaller defects, and even obliterate a frontal sinus. There is minimal donor-site morbidity, and complications have not been seen in a series of nine consecutive patients.

Adult↗
PubMed1996

Evaluation of the anatomical position of the lateral canthal ligament: clinical implications and guidelines.

Controversy exists in the literature as to the precise anatomical location of the lateral canthal ligament. The ligament is a 3 mm-wide, two-tailed band; its average length is approximately 13 mm, while the width of the rima palpebralis is about 26 mm. The authors evaluated three different groups to pinpoint the anatomical position of the ligament's attachment to the lateral orbital wall, and to establish guidelines for placement of the ligament during surgery. In 90% of the cases, the ligament was attached to Whitnall's tubercle, which is located approximately 4 mm posterior to the lateral orbital rim, and 17 mm above the intersection of the lateral and inferior margins; this area is 9 mm below the zygomaticofrontal suture. Based on these anatomical criteria, a standardized procedure is suggested.

Adolescent↗
PubMed1996

Orbitometer-ophthalmometer: new surgical and clinical device.

On the basis of analysis of the orbital bony architecture and the locations of the medial and lateral canthi, as well as the pupillary position, a new orthomorphic linear scale was devised for orbital surgery. The measuring device was designed to facilitate hard- and soft-tissue repositioning during mono-orbital and biorbital surgery. The device is useful for craniofacial, reconstructive, and periorbital trauma surgery and, to the best of our knowledge, is the first one described.

Cephalometry↗
PubMed1994

Radiologic analysis of the effects of subperiosteal palatal soft-tissue expansion in growing cats.

Palatal soft-tissue expansion might be appropriate for use in cleft palate surgery. Seventy-five cats were divided into four different experimental groups and one control group. Intraoral tissue expansion was started at the age of 14 weeks in normal or scarred mucoperiosteum. The experiment lasted until 24 weeks of age. Serial standardized lateral cephalograms from each animal were digitized, and the results were statistically analyzed. The results indicate that the effects are independent of the presence of scarred tissue, that sagittal growth is impaired by tissue expansion, and that the tissue expander induced resorption of palatal bone.

Analysis of Variance↗
PubMed1994

Differentiation of multiple giant cell lesions, Noonan-like syndrome, and (occult) hyperparathyroidism. Case report and review of the literature.

The history is reported of a boy known to have von Recklinghausen neurofibromatosis and multiple recurrent central giant cell granulomata of the mandible and maxilla. This paper discusses the problem of differentiating multiple central giant cell granulomata, Noonan-like/multiple giant cell lesion syndrome, and brown tumor resulting from (occult) hyperparathyroidism.

Adolescent↗
PubMed1994

[Corrections after facial trauma. Experiences with secondary periorbital corrections].

Corrective surgery after primary treatment of periorbital trauma is indicated for functional as well as aesthetical reasons. These indications and the over-all results will be discussed, based on 56 cases. Surgical techniques such as osteotomy of the malar bone or correction of the nose will be presented. It is concluded that 60% of the cases achieve a good, final result. In another 30% considerable improvements have been realized.

Esthetics↗
PubMed1993

Timing and transplant materials for closure of alveolar clefts. A clinical comparison of 296 cases.

A retrospective study of bone grafting of 296 clefts (165 unilateral and 131 bilateral was required) to answer questions about the most favourable timing and the most appropriate bone graft material. The results as such are not exceptional in comparison with earlier publications by the same or other authors, but it is of special interest that operations with different graft materials applied at different times in development, in (usually) a sufficient number of cases, can be compared together. The patients have been operated on during a period of 11 years, by the same surgeons, applying the same principles and techniques. It is shown that early secondary grafting, before the eruption of the canine, results in by far, the highest success rate. Similarly, chin bone is considerably better than any other type of transplant. Aspects of general planning, timing, technique and failures are extensively discussed. Besides the afore-mentioned most significant findings, it is also concluded that the results of grafting during osteotomies are better than they appear; that tertiary grafting is extremely difficult, and requires special surgical skill; that rib grafts score as high as iliac crest grafts and that materials other than these three types of bone should be avoided.

Alveolar Process↗
PubMed1991

Early secondary osteotomy-stabilization of the premaxilla in bilateral clefts.

Using the same arguments as for early bone grafting of the alveolar process in unilateral clefts, the cleft team of the University of Nijmegen started about 10 years ago to apply early osteotomy-stabilization of the premaxilla to bilateral clefts. A series of 13 cases with a minimum follow-up of 15 months is presented. The patients were operated on at the age of 8 2/12 to 12 5/12 years. The results are considerably better than when doing the same operation in the adult. More than 90% are successful. In comparison with adults we additionally register more favourable eruption of the canine, the possibility of closing the dental arch without prosthetic appliances and in some cases also the elimination of a psychological handicap. The inhibition of growth by this operation seems not to be important. If need be, Le Fort I osteotomies are possible after completion of growth. They will be in one piece which is technically easier than the usual three-segment Le Fort I. In conclusion we prefer early secondary osteotomy and stabilization of the premaxilla to the tertiary operation.

Alveoloplasty↗