Adjuvant tamoxifen in postmenopausal patients with breast cancer and negative axillary lymph nodes.
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Breast Neoplasms↗
Biomedical subjects
P Aiginger
Publications and source records attributed to P Aiginger.
Risk factors for bilateral testicular germ cell tumors. Does heredity play a role?
Twenty-three bilateral testicular germ cell tumors (four synchronous and 19 sequential tumors) were investigated for potential risk factors. The incidence of maldescensus testis was not found to be higher than in patients with unilateral disease. The histologic findings of the first tumor did not have any effect on the incidence of the second tumor. In 21 patients (four synchronous and 17 sequential tumors), histocompatibility antigens (HLA) were determined; HLA-B14 was increased significantly in the sequential tumor group. Tendencies toward an increase of HLA-DR5 and HLA-DR7 also were found. The HLA-DR1, HLA-DR3, and HLA-DR4 showed a tendency toward a decreased frequency. Therefore genetic factors might be important in the development of sequential bilateral testicular cancers.
Adult↗
Adjuvant tamoxifen in postmenopausal stage II breast cancer five years on.
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Antineoplastic Combined Chemotherapy Protocols↗
[The biological classifications of malignant thyroid tumours (author's transl)].
Carcinomas of the thyroid gland display large pathological and clinical variation. Favourable prognostic factors accompary well-differentiated tumours, whereas poorly differentiated or anaplastic carcinomas tend to invade early and are usually rapidly fatal. Experience has demonstrated the difference in rate of growth, subsequent recurrence and late spread even in identically well-differentiated thyroid carcinomas. Biological difference must be the underlying reason for the clinical difference in behaviour of histologically similar cancers. This report demonstrates the correlation between in vivo radioactive iodine uptake, tumour staging and recurrence-free interval in 30 thyroid carcinomas. The uptake by well-differentiated carcinomas staged T2N0M0 is significantly higher than that by tumours staged T3N1M0, whereas the latter show a higher uptake than those tumours staged T3N1M0. A high tumour uptake rate is correlated with long recurrence-free interval (up to 24 months) within all groups of staging and vice versa.
Humans↗
[Circulating immune complexes in patients with malignant diseases].
Circulating immune complexes were determined by a solid phase C1q assay in patients with divers malignancies. In Hodgkin's disease (n = 20), immune complexes were detected only in two patients during chemotherapy. Both patients succumbed shortly thereafter. In patients with testicular malignancies (n = 18), immune complexes were detected especially in patients without evidence of metastatic disease. Sequential investigations did not reveal prognostic insights. Summing up these data and the data obtained in additional patients with malignancies, it is interesting to note, that patients with carcinomas have a significant higher incidence of circulating immune complexes with malignancies of the lymphatic system. Our data, however, do not exclude presence of other than C1q binding immune complexes.
Hodgkin Disease↗
[Diagnosis and therapy of hepatocellular cancer].
A patient with hepatocellular carcinoma of the right liver lobe is presented by case report. Although a right side hemihepatectomy was performed, a recidive was detected 3 months later. Since then he received adriamycin-therapy and 14 months after operation, he is almost completely free of pain. Diagnosis, and surgical as well as internal therapy, are presented.
Carcinoma, Hepatocellular↗
[Oral 5-fluorouracil therapy in liver metastasis].
The therapeutic results of 5-FU given by oral application (15 mg/kg body weight x 10 days) in 11 patients with hepatic metastases (after colorectal and mammary carcinoma) are reported: objective response in 2 patients and subjective improvement in 4 patients contrasts to 3 patients without response and 2 patients with indefinite response to adjuvant chemotherapy. However, a long lasting complete remission in a female patient with important metastatic hepatic involvement following breast cancer must be emphasized.
Administration, Oral↗
[Serum fucosyltransferase activity in malignant diseases].
Serum Fucosyltransferase activities were measured in 41 controls and in 55 patients with neoplastic diseases. Incorporation of 14C-fucose into the endogenous acceptor of serum and after addition of desialofetuin as exogenous acceptor, was determined. About 83% of patients suffering from various malignant diseases showed pathological fucosyltransferase activities. In all patients with testicular tumours and no detectable metastases after surgery, normal enzyme levels were obtained. After successful chemotherapy, fucosyltransferase activities returned to normal.
Female↗
[Anemia in patients with malignant testicular tumors].
Changes in erythropoiesis were studied in 94 patients with testicular germ cell tumours (24 seminoma, 70 nonseminomatous tumours). Additionally ferrokinetic studies with 59Fe were performed in 29 patients with proven metastases. Only 2 of 37 tumour-free patients sustained moderate anemia after recess of primary therapy (2 seminoma, after X-ray-irradiation). In patients with disseminated tumour disease the anemia and the reduction of 59Fe-utilisation correlated positively with the elevation of serum estradiol concentrations, whereas no correlation could be established with testosterone serum levels.
Anemia, Hypochromic↗
[Ixoten therapy in malignant lymphomas].
Clinical experience with Ixoten (trofosfamide), a derivative of cyclophosphamide, is reported in 29 patients with malignant lymphomas. Daily doses of 150-300 mg p.o. and 6.000-200.000 mg total dose respectively, resulted in an 80% complete or partial remission. In addition to a dose dependent haematotoxicity, other side effects (gastrointestinal and/or hair loss) were almost negligible.
Adult↗
[Hemolytic anemia in Hodgkin's disease].
In 12 of 128 patients with Hodgkin's disease (10%) haemolytic anaemia could be observed. In 3 of 12 patients an (auto-)immunological etiology of haemolysis was proven by the positive antiglobulin-test. In the rest of patients (9 of 12) the haemolytic syndrome could be explained by the concomitant enlargement of the spleen. In addition to high-dose prednisolone, splenectomy is the method of choice for the treatment of the haemolytic syndrome (4 of 6 patients). If adequate treatment of Hodgkin's disease is provided, the disease (2--37 months) will not be influenced by haemolytic anaemia.
Adolescent↗
HLA antigens and De Quervain's thyroiditis.
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Epitopes↗
Copper in ankylosing spondylitis and rheumatoid arthritis.
To study the role of copper in inflammatory rheumatic diseases, serum copper, serum ceruloplasmin concentration, erythrocyte sedimentation rate, and radio-copper studies were performed in 11 male patients with ankylosing spondylitis, in 12 female patients with rheumatoid arthritis and in 7 normal male subjects. The occurrence of elevated serum copper and serum ceruloplasmin levels can be confirmed in our study for patients with ankylosing spondylitis and rheumatoid arthritis when compared with normal controls. A significant correlation was found for these parameters and the inflammatory activity, characterized by the erythrocyte sedimentation rate. If groups with similar inflammatory activity are compared, higher ceruloplasmin concentrations are found in ankylosing spondylitis than in rheumatoid arthritis, the plasma incorporation of radiocopper also being higher in ankylosing spondylitis patients. Therefore, and because of comparable total serum copper concentrations, the non-ceruloplasmin bound copper level is found to be significantly higher in rheumatoid arthritis patients than in the group of ankylosing spondylitis patients. The significant correlation between erythrocyte sedimentation rate and the cumulative 120-hour urine excretion of radiocopper is in good agreement with the chemical finding of an elevated urinary copper excretion found by others, supporting the concept that the elevation of serum and urine copper levels in inflammatory rheumatoid diseases can be considered as an acute phase response.
Adolescent↗
[Pathogenesis of hyperthyroidism].
The present concept for the etiology of thyroid disease permits the definition of three separate entities occuring with hyperthyroidism: Graves' Disease, Toxic Nodular Goitre, Autonomous Adenoma. Physiopathological properties of these entities lead to a rational therapeutic strategy for each one of them.
Adenoma↗
[Steroid receptors--their meaning in the treatment of breast neoplasms].
Quantitation of estrogen and progesterone receptors in breast cancer has contributed to a better understanding of the prognosis of hormone treatment. In case of lymph node involvement adjuvant chemotherapy is indicated in estrogen receptor negative tumours. In patients with positive estrogen receptor pattern, hormone treatment eventually combined with chemotherapy is recommended. Comparable results are found after treatment with antiestrogens, side-effects, however, are found less frequently.
Breast Neoplasms↗
[Therapeutic progress in malignant testicular neoplasms].
Besides the progress of surgical and radiological regimens it is a new approach in cytostatic chemotherapy which has improved the prognosis of testicular tumours. Combination chemotherapy results in a 70 to 100% remission rate and a prolonged duration of survival.
Antineoplastic Agents↗
[Diagnostic progress in testicular carcinoma].
The diagnostic value of the serum tumour markers, beta-HCG and AFP, is investigated in 71 patients with malignant testicular tumours. Regular screening with beta-HCG and AFP, has improved the early diagnosis of recurrences and metastases in nonseminomatous testicular tumours.
Choriocarcinoma↗
[Behaviour of erythrocytes in patients with aortic of mitral stenosis (author's transl)].
The behaviour of red blood cells was studied in 17 patients with aortic stenosis and 14 patients with mitral stenosis. Anemia was present only in 1 out of 17 patients with highgraded aortic stenosis. 8 of the 17 patients showed a reduced survival time of the red blood cells indicating hemolysis in a compensated stage. 14 cases of mitral stenosis showed no evidence of hemolysis. There was a significant inverse relationship (r = --0,85) between the valve gradient and the survival time of the erythrocytes in patients with aortic stenosis; valve area and survival time were directly related (r = 0,75). In mitral stenosis, there was no significant correlation between gradient or valve area and survival time. This suggests that the gradient through the valve rather than the reduced valve area is responsible for the damage of the erythrocytes; in addition, hemolysis appears to be dependent on pressure gradient rather than on valve pathology or reduction of valve area per se.
Anemia↗