Biomedical subjects

P Alku

Publications and source records attributed to P Alku.

At least 19 recordsLinked to original sources

PubMed2006

Auditory perception and attention as reflected by the brain event-related potentials in children with Asperger syndrome.

OBJECTIVE: Language development is delayed and deviant in individuals with autism, but proceeds quite normally in those with Asperger syndrome (AS). We investigated auditory-discrimination and orienting in children with AS using an event-related potential (ERP) paradigm that was previously applied to children with autism. METHODS: ERPs were measured to pitch, duration, and phonetic changes in vowels and to corresponding changes in non-speech sounds. Active sound discrimination was evaluated with a sound-identification task. RESULTS: The mismatch negativity (MMN), indexing sound-discrimination accuracy, showed right-hemisphere dominance in the AS group, but not in the controls. Furthermore, the children with AS had diminished MMN-amplitudes and decreased hit rates for duration changes. In contrast, their MMN to speech pitch changes was parietally enhanced. The P3a, reflecting involuntary orienting to changes, was diminished in the children with AS for speech pitch and phoneme changes, but not for the corresponding non-speech changes. CONCLUSIONS: The children with AS differ from controls with respect to their sound-discrimination and orienting abilities. SIGNIFICANCE: The results of the children with AS are relatively similar to those earlier obtained from children with autism using the same paradigm, although these clinical groups differ markedly in their language development.

Acoustic Stimulation↗

PubMed2006

Speech- and sound-segmentation in dyslexia: evidence for a multiple-level cortical impairment.

Developmental dyslexia involves deficits in the visual and auditory domains, but is primarily characterized by an inability to translate the written linguistic code to the sound structure. Recent research has shown that auditory dysfunctions in dyslexia might originate from impairments in early pre-attentive processes, which affect behavioral discrimination. Previous studies have shown that whereas dyslexic individuals are deficient in discriminating sound distinctions involving consonants or simple pitch changes, discrimination of other sound aspects, such as tone duration, is intact. We hypothesized that such contrasts that can be discriminated by dyslexic individuals when heard in isolation are difficult to identify when occurring within words or structurally similar complex sound patterns. In the current study, we addressed how segments of pseudo-words and their non-speech counterparts are processed in dyslexia. We assessed the detection of long-duration differences in segments of these stimuli and identified the brain processes that could be associated with the behavioral results. Consistent with previous studies, we found no early cortical sound-duration discrimination deficit in dyslexia. However, differences between impaired and non-impaired readers were found in the brain processes associated with sound-change recognition as well as in the behavioral performance. This suggests that even when the early, automatic, sound discrimination processes are intact in dyslexic individuals, deficits in the later, attention-dependent processes may lead to impaired perception of speech and other complex sounds.

Acoustic Stimulation↗

PubMed2005

The effect of different noise types on the speech and non-speech elicited mismatch negativity.

The effect of different types of real-life noise on the central auditory processing of speech and non-speech sounds was evaluated by the means of mismatch negativity and behavioral responses. Subjects (19-34 years old; 6 males, 4 females) were presented, in separate conditions, with either speech or non-speech stimuli of approximately equal complexity in five background conditions: babble noise, industrial noise, traffic noise, wide band noise, and silent condition. Whereas there were no effects of stimuli or noise on the behavioral responses, the MMN results revealed that speech and non-speech sounds are processed differently both in silent and noisy conditions. Speech processing was more affected than non-speech processing in all noise conditions. Moreover, different noise types had a differential effect on the pre-attentive discrimination, as reflected in MMN, on speech and non-speech sounds. Babble and industrial noises dramatically reduced the MMN amplitudes for both stimulus types, while traffic noise affected only speech stimuli.

Acoustic Stimulation↗

PubMed2005

ERPs differentiate syllable and nonphonetic sound processing in children and adults.

We examined maturation of speech-sound-related indices of auditory event-related brain potentials (ERPs). ERPs were elicited by syllables and nonphonetic correlates in children and adults. Compared with syllables, nonphonetic stimuli elicited larger N1 and P2 in adults and P1 in children. Because the nonphonetics were more perceptually salient, this N1 effect was consistent with known N1 sensitivity to sound onset features. Based on stimulus dependence and independent component structure, children's P1 appeared to contain overlapping P2-like activity. In both subject groups, syllables elicited larger N2/N4 peaks. This might reflect sound content feature processing, more extensive for speech than nonspeech sounds. Therefore, sound detection mechanisms (N1, P2) still develop whereas sound content processing (N2, N4) is largely mature during mid-childhood; in children and adults, speech sounds are processed more extensively than nonspeech sounds 200-400 ms poststimulus.

Acoustic Stimulation↗

PubMed2004

The auditory n100m response reflects changes in speech fundamental frequency.

We studied the cortical activation underlying perception of variations in speech fundamental frequency (F0) as indexed by the amplitude, latency and source location of the auditory N100m response registered with magnetoencephalography (MEG). Ten subjects were presented with Finnish vowels with either a constant or an ascending/descending F0. We found that the human auditory cortex is sensitive to these time-varying changes in the F0 of speech: vowels with a constant F0 elicited more prominent N100m responses than did vowels with ascending or descending changes in F0. These results suggest that the speech-related behavior of the N100m arises out of cortical sensitivity to variations in the F0 and its harmonics which underlie the perception of pitch and intonation. The present observations are interpreted in terms of the interrelatedness of speech production and perception.

Acoustic Stimulation↗

PubMed2004

Periodic glottal excitation and formant frequencies in the perception of vowels.

Voiced speech is created by the fluctuating vocal folds generating the glottal pulseform. This excitation signal is the source of the speech fundamental frequency and its harmonic integer multiples. Periodic glottal excitation is required for the elicitation of speech-specific cortical processes indexed by the auditory N100m response. Here, we studied the cortical processing underlying the perception of the vowels /a/ and /u/ produced using normal and aperiodic phonation. The behavior of the N100m, registered with magnetoencephalography (MEG), was studied in 10 subjects. The amplitude and latency of the N100m as well as the center of gravity of the activated cortical areas varied as a function of stimulus periodicity. Further, the presence of glottal excitation had differential effects on the latency of the N100m elicited by the vowels /a/ and /u/. Thus, changes affecting the perceptual quality of speech signals without changing their phonetic content modify the dynamics of human auditory cortex.

Acoustic Stimulation↗

PubMed2004

Behavioral detection of spatial stimuli is reflected in auditory cortical dynamics.

We studied the cortical processing of spatial stimuli by magnetoencephalographic (MEG) measurements using broadband noise bursts presented from eight sound source directions in the horizontal plane. The stimuli were individually created for each subject by using three-dimensional (3D) sound techniques. The subjects carried out a behavioral task where their accuracy for localizing the 3D stimuli was established. We found that the auditory N100m response was sensitive to the sound source direction, exhibiting contralaterally more preponderant responses in both the left and the right hemisphere. Generally, responses were more prominent in the right hemisphere. The behavioral performance of the subjects correlated positively with N100m amplitude organization, showing that the dynamics of auditory cortex predict behavioral sound detection.

Acoustic Stimulation↗

PubMed2004

Cortical activity elicited by isolated vowels and diphthongs.

Cortical activity underlying speech perception has been studied mostly by using isolated vowels with constant formant frequencies. Speech, however, is characterized by formant transitions whereby formant frequencies change as a function of time. We used magnetoencephalography (MEG) to investigate cortical activity elicited by isolated vowels and diphthongs containing formant transitions. Ten subjects were presented with two isolated vowels /a/ and /u/ and diphthongs /au/ and /ua/. Stimulus duration was 200 ms, and the diphthongs started and ended with a 50-ms constant-formant period and included a 100-ms linear transition period. Apart from studying the auditory N100m response, we examined subsequent brain activity in a 500-ms poststimulus time window, as the transitions were expected to elicit activity also in later stages of cognitive processing. All the stimuli elicited prominent N100m responses. Thereafter, both the isolated vowels and diphthongs elicited sustained brain activity lasting up to 500 ms. The present observations indicate that identification of the speech sounds as well as changes in their identity are reflected in the auditory N100m. Notably, the stimuli appeared to elicit left-hemispheric activity resembling the N400, typically obtained by using more complicated speech stimuli such as words and sentences.

Acoustic Stimulation↗

PubMed2004

Event-related potentials associated with sound discrimination versus novelty detection in children.

In children, deviant sounds in an oddball paradigm elicit a mismatch negativity (MMN) indexing discrimination of sound change and late difference negativity (LDN) with unknown functional significance. Salient sounds elicit an ERP index if orienting, P3a, and a late negative component, Nc. We compared children's responses elicited by moderate sound changes and novel sounds to examine the relationships between MMN and LDN, and LDN and Nc. Two components of the Nc, the Nc1 and Nc2, were identified. The scalp topography of LDN differed from those of the MMN and Nc1. Children's early P3a appeared mature but late P3a lacked frontal predominance. The findings suggested that LDN is not linked with either the sensory or attentional processing. It might reflect cognitive, albeit preattentive, processing of sound change. The Nc1 appears to reflect cognitive attentive processing of salient stimuli and the Nc2 might reflect reorienting after distraction.

Adolescent↗

PubMed2003

Speech-sound-selective auditory impairment in children with autism: they can perceive but do not attend.

In autism, severe abnormalities in social behavior coexist with aberrant attention and deficient language. In the attentional domain, attention to people and socially relevant stimuli is impaired the most. Because socially meaningful stimulus events are physically complex, a deficiency in sensory processing of complex stimuli has been suggested to contribute to aberrant attention and language in autism. This study used event-related brain potentials (ERP) to examine the sensory and early attentional processing of sounds of different complexity in high-functioning children with autism. Acoustically matched simple tones, complex tones, and vowels were presented in separate oddball sequences, in which a repetitive "standard" sound was occasionally replaced by an infrequent "deviant" sound differing from the standard in frequency (by 10%). In addition to sensory responses, deviant sounds elicited an ERP index of automatic sound-change discrimination, the mismatch negativity, and an ERP index of attentional orienting, the P3a. The sensory sound processing was intact in the high-functioning children with autism and was not affected by sound complexity or "speechness." In contrast, their involuntary orienting was affected by stimulus nature. It was normal to both simple- and complex-tone changes but was entirely abolished by vowel changes. These results demonstrate that, first, auditory orienting deficits in autism cannot be explained by sensory deficits and, second, that orienting deficit in autism might be speech-sound specific.

Auditory Diseases, Central↗

PubMed2003

Event-related potential indices of auditory vowel processing in 3-year-old children.

OBJECTIVE: To determine the ERP characteristics and ERP indices of central speech sound encoding and discrimination in young children. METHODS: Auditory sensory event-related potentials (ERPs) and the ERP index of auditory sensory discrimination (the mismatch negativity, MMN) were elicited by vowel stimuli in 3-year-old children. In an oddball paradigm, the standard stimulus was vowel /a/, one deviant stimulus was vowel /o/ (the across-category change), and the other was nasalized vowel /a/ (within-category change). In addition, the ERP changes occurring during the 14 min uninterrupted recording were examined. RESULTS: As indexed by the sensory P1, N2, and N4 peaks, the 3-year-old children's transient neural encoding of vowels was comparable to that earlier registered in 1-year-old children but also showed vowel-specific characteristics observed in school-age children. The 3-year-old's MMN was comparable in amplitude to the school-age children's MMN and appeared to be sensitive to the across-category aspects of vowel changes. However, its latency was longer in the 3-year-olds than in school-age children. Among the sensory ERPs, only the N4 peak showed significant diminution during the experiment. The across-category change MMN diminished after 10 min of the recording, however, over the frontal areas only. CONCLUSIONS: In the 3-year-old children, the sensory processing of vowels exhibited transitional characteristics between those observed in infants and school-age children. The auditory sensory discrimination in the 3-year-olds appeared to be sensitive to the phonemic aspects of stimulus change. The frontally-predominant MMN diminution during the experiment might indicate the greater refractoriness of its frontal-lobe generators. In general, the auditory sensory ERPs show distinct maturational profiles from that of the MMN.

Acoustic Stimulation↗

PubMed2001

Long-term memory traces facilitate short-term memory trace formation in audition in humans.

Long-term memory traces of one's native language have an effect on the short-term memory traces formed by phonemes, Nature 385 (1997) 432. We investigated whether they also affect the number of stimulus repetitions needed to form an adequate memory trace used in the elicitation of the mismatch negativity (MMN), an event-related response to a change in an ongoing sound stream. We recorded MMNs to infrequent stimuli occurring in trains of prototype and non-prototype phonemes, matched in their physical distances, and in trains of sinusoidal tones. We found that the number of standards needed to produce a prominent MMN was smaller for native-language prototype phonemes than to non-prototype phonemes, suggesting a faster trace development.

Adult↗

PubMed2001

The periodic structure of vowel sounds is reflected in human electromagnetic brain responses.

Periodicity, which is caused by the vibration of the vocal folds, is an inherent feature of vowel sounds. Whether this periodic structure is reflected in cerebral processing of vowels was addressed via the use of non-invasive brain research methods combined with advanced stimulus production methodology. We removed the contribution of the source of the periodic structure, the glottal excitation produced by the vocal folds, from vowel stimuli and found that electromagnetic responses generated in the auditory cortex reflect this removal. The N1(m) amplitude decreased even though the rest of the acoustical features of the stimuli were identical. Thus, we conclude that speech production mechanisms have significant effects on human brain dynamics as reflected by magnetoencephalography and electroencephalograph.

Acoustic Stimulation↗

PubMed2001

Memory traces for words as revealed by the mismatch negativity.

Brain responses to the same spoken syllable completing a Finnish word or a pseudo-word were studied. Native Finnish-speaking subjects were instructed to ignore the sound stimuli and watch a silent movie while the mismatch negativity (MMN), an automatic index of experience-dependent auditory memory traces, was recorded. The MMN to each syllable was larger when it completed a word than when it completed a pseudo-word. This enhancement, reaching its maximum amplitude at about 150 ms after the word's recognition point, did not occur in foreign subjects who did not know any Finnish. These results provide the first demonstration of the presence of memory traces for individual spoken words in the human brain. Using whole-head magnetoencephalography, the major intracranial source of this word-related MMN was found in the left superior temporal lobe.

Adult↗

PubMed2001

Objective analysis of vocal warm-up with special reference to ergonomic factors.

Vocal warm-up was studied in terms of changes in voice parameters during a 45-minute vocal loading session in the morning. The voices of a randomly chosen group of 40 female and 40 male young students were loaded by having them read a novel aloud. The exposure groups (5 females and 5 males per cell) consisted of eight combinations of the following factors: (1) low (25 +/- 5%) or high (65 +/- 5%) relative humidity of ambient air; (2) low [< 65 dB(SPL)] or high [> 65 dB(SPL)] speech output level during vocal loading; (3) sitting or standing posture during vocal loading. Two sets of voice samples were recorded: a resting sample before the loading session and a loading sample after the loading session. The material recorded consisted of /pa:ppa/ words produced normally, as softly and as loudly as possible in this order by all subjects. The long /a/ vowel of the test word was inverse-filtered to obtain the glottal flow waveform. Time domain parameters of the glottal flow [open quotient (OQ), closing quotient (CQ), speed quotient (SQ), fundamental frequency (F0)], amplitude domain parameters of the glottal flow [glottal flow (fAC) and its logarithm, minimum of the first derivative of the glottal flow (dpeak) and its logarithm, amplitude quotient (AQ), and a new parameter, CQAQ], intraoral pressure (p), and sound pressure level (SPL) values of the phonations were analyzed. Voice range profiles (VRP) and the singer's formant (g/G, a/A, cl/c, e1/e, g1/g for females/males) of the loud phonation were also measured. Statistically significant differences between the preloading and postloading samples could be seen in many parameters, but the differences depended on gender and the type of phonation. In females the values of CQ, AQ, and CQAQ decreased and the values of SQ and p increased in normal phonations; the values of fAC, dpeak, and SPL increased in soft phonations; the values of AQ and CQAQ decreased in loud phonations; the harmonic energy in the singer's formant region increased significantly at every pitch. In males the values of OQ and AQ decreased and the values of dpeak, F0, p, and SPL increased in normal phonations; the values of fAC and p increased in soft phonations. The changes could be interpreted as signs of a shift toward hyperfunctional voice production. Low humidity was associated with more hyperfunctional changes than high humidity. High output was associated with more hyperfunctional changes than low output. Sitting position was associated with an increasing trend at both margins of male VRP, whereas the case was the opposite for standing position.

Adolescent↗

PubMed2001

Are different kinds of acoustic features processed differently for speech and non-speech sounds?

This study examined how changes in different types of acoustic features are processed in the brain for both speech and non-speech sounds. Event-related potentials (ERPs) were recorded in native Finnish speakers presented with sequences of repetitive vowels (/e/) or complex harmonical tones interspersed with infrequent changes in duration, frequency and either a vowel change (/o/ for vowel sequences) or a double deviant (frequency+duration change for tone sequences). The stimuli were presented monaurally in separate blocks to either the left or right ear. The results showed that speech stimuli were more efficiently processed than harmonical tones as reflected by an enhanced mismatch negativity (MMN) and P3a ERP components. In addition, the duration change in vowels elicited a larger MMN component than the equivalent change in tones. This result might reflect enhanced processing of duration features in the Finnish language in which phoneme duration plays a critical role.

Acoustic Stimulation↗

PubMed2001

Central auditory processing of durational changes in complex speech patterns by newborns: an event-related brain potential study.

In this study, newborns' ability to discriminate durational changes in the fricative /s/ within a nonsense word was investigated. The results showed that infrequent increments and decrements of a speech sound duration elicit a mismatch negativity kind of response in sleeping human newborns. In the auditory event-related potential to these deviant stimuli two negative waves of this response were revealed. The first negative wave peaked at about 150 msec and the second at about 350 msec after the change onset. At least one negative deflection, which was interpreted as evidence for stimulus change-detection, was observed in every infant.

Adult↗

PubMed2001

Children's auditory event-related potentials index sound complexity and "speechness".

Children's long-latency auditory event-related potential (LLAEP) structure differs from that of adults. Functional significance of childhood ERP components is largely unknown. In order to look for the functional correlates in adult and children's LLAEPs, stimulus-complexity effects were investigated in 8-10-year old children. To this end, auditory ERPs to vowels, acoustically matched complex tones, and sinusoidal tones were recorded. All types of stimuli elicited P100-N250-N450 ERP complex. Differences between the sinusoidal and complex tones were confined to the P100 and N250 peaks, complex tones eliciting larger responses. Vowels elicited smaller-amplitude N250 but larger-amplitude N450 than the complex tones. Some stimulus-complexity effects observed for N250 in children corresponded to those observed for the N1 in adults, whereas the N450 peak exhibited behaviour resembling that of the adult ERP components subsequent to the N1 wave.

Brain↗