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Biomedical subjects

P Allmendinger

Publications and source records attributed to P Allmendinger.

7 recordsLinked to original sources
PubMed2002

Calcified abdominal aortic aneurysm in a 12-year-old boy.

The authors report a case of an idiopathic, isolated infrarenal abdominal aortic aneurysm with dense intramural calcification and sterile mesenteric lymphadenopathy in a 12-year-old boy. Aneurysmal disease in the pediatric population is very uncommon. The majority of previously reported cases have clear associated causes, such as connective tissue disorders, infectious processes, inflammatory states, or trauma. A minority of cases have no distinguishable cause and are classified as idiopathic. Isolated abdominal aortic aneurysms are very uncommon in children, and those with densely calcified walls are rare, with only 2 case reports in the literature. The authors found no previous reports of abdominal aortic aneurysm with associated sterile mesenteric lymphadenopathy. The etiology of this patient's aneurysm remains unknown.

Aortic Aneurysm, Abdominal↗
PubMed1998

Bloodless medicine and surgery.

Our hospital is a center for bloodless medicine and surgery (CBMS). It is one of 56 such centers located in the United States. The mission of the center is to provide surgical and medical treatment without the administration of blood or blood-related products. Patients' rights to autonomy and self-determination are respected. Development of the CBMS program required the writing and implementation of specific guidelines, developing standards of care, revising existing policies and procedures, and educating staff members. The CBMS program is multifaceted and multidisciplinary.

Advance Directives↗
PubMed1989

Ventricular pseudoaneurysm associated with cardiopulmonary resuscitation 6 weeks after mitral valve replacement.

Trauma to the heart and mediastinum is associated with external cardiac massage. A patient had undergone a redo mitral valve replacement and experienced an uneventful postoperative course. During a visit to her physician 6 weeks after operation, she experienced ventricular fibrillation that required external cardiac massage and subsequent defibrillation. Postresuscitation evaluation revealed a posterior pseudoaneurysm of the ventricle. This was repaired via a transthoracic approach with the use of profound hypothermia.

Aged↗
PubMed1987

Hypothermic circulatory arrest in the treatment of thoracic aortic lesions.

The use of hypothermic circulatory arrest has been established in the treatment of aortic arch lesions. We recently used this method of arrest in the treatment of 10 consecutive patients with thoracic aortic lesions. Seven of these patients had dissecting aneurysms of the ascending aorta with extension into the aortic arch. One patient had a mycotic aneurysm of the arch, and 2 patients had arteriosclerotic aneurysms of the ascending aorta and entire aortic arch. All patients were supported and cooled with cardiopulmonary bypass. Circulatory arrest was maintained for periods of 21 to 63 minutes. All 10 patients survived the operative procedure. Nine patients remained intact neurologically. Renal function returned to baseline in all patients. Average blood replacement was 2.9 units. All patients have experienced an excellent surgical result. The average follow-up is 21.1 months. The technique facilitates a surgical approach to these lesions and appears to be the safest form of vital-organ preservation.

Adult↗
PubMed1984

F-Met-Leu-Phe and echo 9 virus interaction with human granulocytes. Changes of cell membrane structure.

Biophysical and biochemical methods were applied for investigation of cell membrane properties of human polymorphonuclear leukocytes (PMNs) exposed to the chemotactic peptide N-formylmethionyl-leucylphenylalanine (f-Met-Leu-Phe) and echovirus type 9, strain A, Barty. Steady-state fluorescence depolarization with diphenylhexatriene demonstrated no gross changes of the total membrane fluidity under the different experimental conditions. However, by means of the monomer-excimer technique with pyrenedecanoic acid (PDA), significant changes of the local membrane structure were detected for both agents. As demonstrated by a higher excimer ratio, the membrane area available for the PDA molecules was restricted by f-Met-Leu-Phe. This effect was dependent on the dose and on the time of interaction of the chemotactic peptide. These experimental findings were explained by the formation of functional receptor units ("activated membrane"). Echo 9 virus exhibited the opposite effect, characterized by a higher ratio of monomers, which also depended on the viral dose and the time of virus-PMN interaction. These virus-induced findings were explained by the dissolution of functional receptor units. Consecutive exposure of the PMNs to f-Met-Leu-Phe and echovirus, or vice versa, demonstrated a virus-predominant effect on the membrane structures.

Cell Membrane↗