Anetoderma in a patient with juvenile xanthogranuloma.
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Elastic Tissue↗
Biomedical subjects
P Ang
Publications and source records attributed to P Ang.
Characteristics of bacterial skin infections in children compared to adults at a tertiary dermatologic center.
BACKGROUND: Bacterial skin infections in children and adults are caused by different organisms with different antimicrobial susceptibility. METHODS: A comparative retrospective study was carried out on 233 adults and 53 children with bacterial skin infections. Skin swab cultures and sensitivity tests were performed using standard methods. Statistical analysis was performed using the Pearson chi-squared and Fisher tests. A P value of < 0.05 was considered to be significant. RESULTS: Primary and secondary skin infections occurred in equal proportions in children, whereas secondary skin infections were more common in adults (70.8%). Staphylococcus aureus was the main cause of skin infections, particularly in children (72.6%). S. aureus in children and adults was highly susceptible to cloxacillin, cephalexin, chloramphenicol, neomycin, cotrimoxazole, and clindamycin, moderately susceptible to erythromycin, and insensitive to tetracycline, ampicillin, and penicillin. CONCLUSIONS: It is important to monitor the trends of bacterial infections and their antibiotic susceptibility as this can assist medical practitioners in their choice of antimicrobial therapy. Such monitoring will also help to detect the emergence of resistant bacterial strains and caution us to take care in the use of certain drugs.
Adolescent↗
Case reports of linear IgA bullous dermatosis of childhood.
Linear IgA bullous dermatosis of childhood (LADC) is an uncommon acquired blistering skin disorder which affects young children. It is characterised by a linear band of IgA at the epidermal basement membrane on direct immunofluorescence. From 1984 to 1988 at the previous skin centre at Middle Road Hospital, and 1989 to 1997 at the present National Skin Centre, a total of 4 cases were seen. All the patients were female and their ages ranged from 5 to 14 years (mean 8 years). There were 2 Chinese, 1 Caucasian and 1 Malay. All presented with an acute onset of blistering of 1 to 3 weeks' duration. Their skin biopsies showed subepidermal bullae with neutrophils, with/without eosinophils and direct immunofluorescence tests revealed linear deposits of IgA along the dermoepidermal junction. All were treated with prednisolone and dapsone with good results. One patient developed dapsone-induced haemolysis and treatment was changed to colchicine. We review the epidemiology, aetiology, current concepts and treatment modalities of this condition.
Adolescent↗
Bullous dermatomyositis associated with nasopharyngeal carcinoma--a case report.
Cutaneous manifestations of dermatomyositis commonly include Gottron's papules, heliotrope rash, photosensitivity, poikiloderma and nailfold telangiectasia. Vesicles and bulla are rare. We report a patient with dermatomyositis who presented with blisters and oral ulcers. It is important to recognise this bullous variant in order to avoid a delay in diagnosis. Bullous dermatomyositis may also portend a poorer prognosis. Our patient was subsequently diagnosed to have undifferentiated nasopharyngeal carcinoma.
Dermatomyositis↗
Sunscreen allergy in Singapore.
We report the epidemiology of sunscreen allergy over a period of 5 years at the National Skin Centre. A total of 61 patients with suspected allergy to sunscreen underwent patch or photopatch testing to our sunscreen series from 1992 to 1996. The results were retrospectively analysed and evaluated. Out of these 61 patients, 5 were found to have positive patch test reactions to sunscreens. 2 were photoallergic, and 3 were allergic to active ingredients in sunscreens. The main causative allergens were 2-ethylhexyl-4-methoxycinnamate (Parsol MCX) and 2-hydroxy-4-methoxybenzophenone (oxybenzone). We conclude that sunscreen contact allergy is uncommon in our practice.
Adult↗
Linear epidermolytic epidermal naevus--a case report.
A 25-year-old man presents with linear verrucous epidermal naevus since birth. A biopsy done showed histological features of epidermolytic hyperkeratosis. Patients with epidermolytic epidermal naevi can give rise to children with a rare but serious condition known as congenital bullous icthyosiform erythroderma. Recently, keratin mutations have been described in both conditions and the relationship between the two can be explained using the concept of genetic mosaicism.
Adult↗
Soldier performance and strenuous road marching: influence of load mass and load distribution.
Fifteen male soldiers performed six maximal-effort, 20-km road marchers. They carried load masses of 34, 48, and 61 kg, using a standard military backpack with frame or an experimental doublepack. March times decreased as mass increased and were faster with the standard pack than with the double-pack. The doublepack resulted in less low back discomfort and a lower incidence of blisters at the highest load, but also resulted in more discomfort in the neck and hips. Neither load mass nor pack type affected soldiers' marksmanship ability, grenade throw accuracy, or cognitive ability. The maximal-effort march itself affected the marksmanship tasks by increasing the post-march vertical shot group dispersion. The concept of distributing the load mass more evenly around the center of mass of the body has both positive and negative aspects and warrants further investigation.
Blister↗
Sexually-transmitted diseases in Singapore--trends in the last two decades.
We review the epidemiology and trends of sexually transmitted diseases (STDs) in Singapore from 1977 to 1996. There has been a progressive decline in the incidence of bacterial STDs over the period of observation. However, viral STDs have not shown the same trends, remaining at a relatively constant level. Early detection and treatment of STDs, and health education and prevention measures targeting sex workers have been a major factor in controlling STDs. Vigilant monitoring of antibiotic resistance patterns in Neisseria gonorrhoeae has allowed timely changes to recommended treatment regimens. The advent of the human immunodeficiency virus (HIV) infection pandemic in the 1980s and public education campaigns have contributed to the success of the STDs control programme. In view of the incurable nature of many viral STDs, prevention and counselling have become a cornerstone of STD control. Surveillance and monitoring of STD trends will continue to provide important information regarding the effectiveness of existing health programmes and help us formulate new plans for the future.
Female↗
Malaria: an audit of 56 cases admitted to a hospital.
A 2-year prospective audit on the profile and outcome of malaria cases admitted to a general hospital was performed. Fifty-six cases were seen from January 1991 to December 1992, 52 of which were due to monoinfections with Plasmodium vivax. The main presenting complaints were fever, chills, sweats, myalgia, dry cough and headache. A significant percentage had anaemia (64.3%), thrombocytopaenia (57.1%), hyponatraemia (42.9%), and liver dysfunction (44.7%). Diagnosis rests on the demonstration of parasites in stained peripheral blood smears. None of the patients developed major complications. A high index of suspicion of malaria must be maintained in the medical evaluation of all patients and in particular, of returning travellers.
Adolescent↗
Physical fitness, age, and injury incidence in infantry soldiers.
Injuries are a common occurrence in young, active civilian and military populations. This study examined injury incidence and the association of musculoskeletal injuries with age and physical fitness in soldiers. Subjects were a cohort of 298 male soldiers assigned to an infantry battalion in Alaska. The soldiers' ages were obtained from the battalion records and their physical fitness was assessed from 2-mile run times, sit-ups, and push-ups. Injuries were documented from a retrospective review of the soldiers' medical records for a 6-month period (October to March) before the fitness testing. Fifty-one percent of the soldiers suffered one or more injuries. The most common injury diagnosis was musculoskeletal pain, followed by strains, sprains, and cold-related injuries. Soldiers experienced a total of 212 separate injuries, which resulted in 1764 days of limited duty. The crude annualized injury rate was 142 injuries per 100 soldiers (one soldier could experience more than one type of injury). The proportion of soldiers injured decreased as age increased. Slower 2-mile run times and fewer sit-ups were associated with a higher incidence of musculoskeletal injuries. This study documents the injury incidence in infantry soldiers and identifies younger age and low physical fitness as potential risk factors for these injuries.
Accidents, Occupational↗
Magnetic resonance imaging of spinal intradural granulocytic sarcoma.
We report the case of a young black male with a spinal intradural granulocytic sarcoma proved by needle aspiration. The tumor was evaluated by myelography, computed tomography, and magnetic resonance imaging (MRI). Other than its rarity, the "dripping candle wax" appearance on MR T1-weighted images and the lack of enhancement with Gd-DTPA makes this case unique. Progressive changes of the tumor following chemo- and radiotherapy were successfully demonstrated by MR.
Adult↗
What syndrome is this? Uncombable hair syndrome (Pili trianguli et canaliculi).
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Child↗
Treatment of linear IgA bullous dermatosis of childhood with colchicine.
Linear IgA bullous dermatosis of childhood is the most common immunobullous disorder of childhood. First-line treatment includes dapsone or sulfapyridine. We report a child with linear IgA dermatosis who was treated successfully with colchicine after developing hemolytic anemia from dapsone. We recommend colchicine as an alternative therapy for linear IgA dermatosis of childhood in patients in whom first-line treatment is contraindicated or who fail first-line treatment or develop side effects from it.
Anemia, Hemolytic↗
Treatment of linear IgA bullous dermatosis of childhood with colchicine: in reply.
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Child, Preschool↗