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Biomedical subjects

P Angulo

Publications and source records attributed to P Angulo.

50 records · Page 3Linked to original sources

Management of primary biliary cirrhosis and autoimmune cholangitis.

Several drugs have been evaluated in the treatment of primary biliary cirrhosis over a number of years. These drugs have immunosuppressive, antiinflammatory, cupruretic, antifibrotic and bile acid properties. Ursodeoxycholic acid has been shown to improve survival free of transplantation in a conclusive fashion. This drug is the single agent that can be recommended for the treatment of primary biliary cirrhosis. Corticosteroid therapy and ursodeoxycholic acid have been evaluated in a few patients with autoimmune cholangitis. This article reviews a large number of studies that have been published assessing different drugs in the treatment of these two entities, particularly in the treatment of primary biliary cirrhosis.

Adrenal Cortex Hormones↗

[Hodgkin's disease. Our 9-year experience with the 1980 protocol].

The purpose of this work was to evaluate the therapeutic results attained with our 1980 protocol for Hodgkin's disease. The usefulness of staging laparotomy was also analysed. Along a 9-year period, 94 patients were diagnosed (stages IA and IIA: 26 cases, IB, IIB and IIIA: 24 cases, and IIIB and IV: 44 cases). The complete remission (CR) rate, as a whole, was 85%; there were 14 relapses, of whom a new CR was attained in 9 instances. The overall actuarial survival is 64% at 47 months. The appearance of 3 cases of acute non-lymphoblastic leukaemia is noteworthy. Laparotomy induced changes of the patient's staging in 49% of cases (rise in 43% and descent in 6%). In account of this, laparotomy seems an adequate procedure in staging, although the criteria for selecting the patients who will undergo this, procedure should be perhaps restrictive.

Actuarial Analysis↗

[Acquired methemoglobinaemia (author's transl)].

Authors report five cases of toxic methemoglobinaemia. Four of them were observed in newborns and the remaining one in a toddler. Acute gastroenteritis, carrot soup and spinachs were recognized as etiologic factors. Up-dated information about this clinical entity, its gasometric diagnosis, hemoglobin spectrophotometry and treatment with methylene blue is briefly recalled.

Female↗

[Photic epilepsy].

Fourteen cases of patients with photoconvulsive response during intermitent luminous stimulation (eleven women and three men) are reviewed. The frequency of the photoconvulsive response was higher between 10 and 20 years of age (eleven cases). Most of the patients (twelve) presented some form of epilepsy and only two had psychomotor retardation without epilepsy. Comment is made on differences published by other authors and possible explanations of such differences are proposed.

Adolescent↗