PubMed Health⌕ Search

Biomedical subjects

P Armario

Publications and source records attributed to P Armario.

At least 19 recordsLinked to original sources
PubMed2003

Blood pressure reactivity to mental stress task as a determinant of sustained hypertension after 5 years of follow-up.

Previous studies have reported an increased risk of developing sustained hypertension (SH) in borderline or mildly hypertensive subjects showing an exaggerated response of blood pressure (BP) to mental stress. The aim of this study was to assess if the response of BP to mental stress tasks is an independent predictor of SH. A total of 89 patients with grade 1 hypertension, aged 18-64 years, 62% males, were included. The mean of follow-up was 5.3 years (s.d. 2.1 years). SH was defined as the development of grades 2-3 hypertension (Systolic BP>or=160 mmHg or diastolic BP>or=100 mmHg) or to be in antihypertensive treatment after follow-up. Two mental stress tasks: mental arithmetic stress task and a stressful interview (SI) were applied at entry. The subjects were classified as hyper-reactors when BP increase was greater than 35 mmHg for systolic BP or greater than 21 mmHg for diastolic BP, according to the results obtained previously in a normotensive control group. In the univariate analysis, the factors associated with the development of SH were age (P=0.0007), office diastolic BP (P=0.014) and hyper-reactivity of BP during a stressful interview (P=0.003). In the Cox regression model, after adjusting for gender, age, and office BP, the hyper-reactivity of BP during SI was an independent predictor of development of SH. In conclusion, the response of BP to mental stress tasks is useful in predicting SH in young and middle-aged subjects with grade 1 hypertension.

Adolescent↗
PubMed2000

Pharmacoeconomic considerations in the management of hypertension.

Hypertension is highly prevalent in developed and developing countries (more than 30% of the adult population when a threshold value of 140/90 mm Hg is selected). It constitutes one of the major cardiovascular risk factors and accounts for more than 5% of total deaths worldwide. The economic impact of hypertension is enormous, representing $US23.74 billion in the US in 1995 and approximately $US1685 million in Spain in 1994. Direct costs amount to more than 50% of the total costs of hypertension, and almost 70% of these are attributable to drug treatment. Furthermore, hypertensive patients use medical services 50% more than normotensive individuals, and hypertension represents one of the 3 leading causes of visits to primary healthcare centres. When considering the cost effectiveness of hypertension treatment, there is no doubt that it is cost effective in comparison with other interventions, although some controversies exist, mainly with respect to mild-to-moderate hypertension and to the long term versus short term benefits. The controversy about the absolute risk of hypertension influences the cost-effectiveness analysis. Because of the limitations of the available cost-effectiveness analyses, it is currently impossible to recommend the use of any particular antihypertensive drug for all patients with hypertension. Consequently, the choice of antihypertensive in any patient should be guided by clinical experience and the recommendations of the present international guidelines.

Adult↗
PubMed1999

[Relationship in cardiovascular reactivity to mental stress and early involvement of target organs in non-treated mild arterial hypertension. Hospitalet Study].

BACKGROUND: It has been previously reported that an exaggerated response of blood pressure to mental stress tasks is associated to an increased cardiovascular risk. The objective of this cross-sectional study, with sequential inclusion of subjects who met the inclusion criteria, was to asses the relationships between the response of blood pressure and heart rate to two different mental stress tasks and early target organ-damage, defined as abnormalities in the echocardiogram and/or an increase of urinary albumin excretion (UAE) or microalbuminuria, in untreated mild hypertensive subjects. SUBJECTS AND METHODS: Two hundred and eleven subjects aged 18 to 65 years (56% males) with mild hypertension (SBP between 140-180 mmHg and/or DBP between 90-105 mmHg) were included in Hospitalet Study. One hundred and thirty seven of them accepted to participate in the study of cardiovascular reactivity. Two different tasks were applied in the same day: a stressful interview (SI) and a mental arithmetic stress tasks (MAST). An echocardiogram of good quality was obtained in 123 cases (89.8%) and 24 h UAE was measured in 108 cases (78.8%). RESULTS: The prevalence of left ventricular hypertrophy was 21.1% (95% CI = 14.3-29.4) and the prevalence of microalbuminuria was 15.7% (95% CI = 9.4-24.4%). After adjusting for the baseline blood pressure, a significant correlation was observed between increase of systolic BP during SI and UAE (r = 0.21; p = 0.03) and between increase of diastolic BP during SI and relative wall thickness (r = 0.32; p < 0.005). When we analyzed the changes of BP during MAST, a significant correlation was observed between increase of diastolic BP (adjusted for baseline diastolic BP) and left atrial size (r = 0.21; p = 0.02). We did not find any significant correlation between the increases of BP (systolic or diastolic) during MAST or increases of heart rate during both tasks and left ventricular mass index or UAE. CONCLUSIONS: A weak correlation was observed between cardiovascular reactivity of blood pressure during mental stress tasks and early target organ damage in mild hypertension. We did not find any relationship between the response to heart rate during the tasks and early target organ damage.

Adult↗
PubMed1999

Determinants of left ventricular mass in untreated mildly hypertensive subjects: hospitalet study in mild hypertension.

The objectives of this cross-sectional study were to identify the determinants of left ventricular mass in untreated mildly hypertensive subjects at the Hypertension Unit, Department of Internal Medicine, Red Cross Hospital, Hospitalet de Llobregat, Barcelona, Spain. One hundred seventy-one untreated mildly hypertensive subjects, with a mean age of 41.1+/-11.8 years (from 18 to 65 years) were sequentially visited in our Unit; 54% were men. Echocardiographic measurements of good quality were obtained in 142 subjects (83%). Two-dimensional guided M-mode echocardiograms were used and left ventricular mass was estimated according to the Penn convention. Left ventricular mass (LVM) was analyzed as a continuous variable. In the bivariate analysis, the variables that significantly correlated with LVM were patient's height (r = 0.42, P<.0005), weight (r = 0.47, P< or =.0005), heart rate (r = -0.22, P = .01), HDLc (r = -0.30, P = .002), hematocrit (r = -0.28, P = .001), urinary sodium excretion (r = 0.23, P = 0.012), and different measurements from the ambulatory blood pressure profile for 24 h. By means of multiple regression analysis, a maximum of 41.2% of LVM variability could be explained from the factors registered in our study. The final model included age, gender, patient's weight, and diastolic night load from ambulatory blood pressure monitoring. When added to different models, weight and diastolic night load showed a similar strength in predicting left ventricular mass. In untreated patients with mild hypertension, traditional factors such as blood pressure levels explain a maximum of 41.2% of LVM variability. More knowledge is needed about factors that may alter cardiac morphology in the evolution of hypertensive patients.

Adolescent↗
PubMed1998

Actions implemented to improve hypertension control in Spain.

Hypertension prevalence is estimated at approximately 30% of the adult population in Spain, using the 140/90 mm Hg cutoff. This represents a heavy public health burden when compared with other European countries, although the direct cost per person is one of the lowest in Europe. The programs implemented regionally since 1985 are presented here. As a result of them, a decade later the number of hypertensives with controlled blood pressure has increased from 10% in 1986 to 13% in 1995, and cerebrovascular mortality has steadily decreased.

Adolescent↗
PubMed1998

[Pathogenesis and epidemiology of arterial hypertension].

The pathogenesis of arterial hypertension is more clearly understood today because of the availability of data enabling identification of a certain number of precipitating factors. From a genetic standpoint, hypertension would appear to be a multifactorial polygenic disorder with a tendency to interact with certain environmental factors. The latter are mainly related to lifestyle and are potentially modifiable. Obesity during childhood and adolescence is the main predictive factor for hypertension. It has been suggested that the underlying mechanism could well be hyperinsulinaemia, which induces hyperactivity of the sympathetic nervous system. The mechanisms of the relationship between hypertension and alcohol are still unclear. However, in many countries, excessive alcohol consumption has been reported to be a significant factor in the development of arterial hypertension. The negative effect of a sedentary lifestyle on blood pressure has been widely demonstrated. In addition, it has also been shown that regular physical exercise under aerobic conditions leads to a reduction in blood pressure levels. An excessive sodium intake is also responsible for inducing arterial hypertension through increases in cardiac output and effects on vascular reactivity and contractility. Similarly, restricting sodium intake leads to a reduction in blood pressure levels. Smoking--namely, certain components of tobacco smoke--would appear to have both short and long term effects on blood pressure. These contributing factors all have specific effects on cardiac output and peripheral resistance in individuals. At the community level, the impact of hypertension is particularly significant. Prevalence is strongly influenced by the type of population studied, although it is generally estimated that this disease affects between 10 and 20% of the adult population and is responsible for 5.8% of all deaths worldwide. The direct and indirect costs of the disease are particularly high and are generally considered to be underestimated since a significant proportion of cardiac disease and stroke should also be included in any cost estimates, giving extremely high final figures. Hypertension-related morbidity and mortality principally result from cardiovascular complications and approximately 35% of atherosclerotic cardiovascular events can be attributed to hypertension. The highest risks are associated with stroke (relative risk: 3.8) and congestive heart failure in individuals with hypertension, in whom the risk is quadrupled. With regard to risk for an individual, the higher the blood pressure the greater the risk for the patient. However, the situation is very different if the entire population is being considered. In this instance, the highest risk is associated with mild hypertension since this involves the largest proportion of the hypertensive population. Similarly, relative risk corresponds to a probability rate that applies to populations rather than individuals. In response to this contradiction, the concept of absolute risk was proposed and corresponds to the prevalence of the disease. The approach to hypertension treatment based on absolute risk has recently been proposed for use in clinical practice. It takes into account lesions of the target organ together with any other risk factors and thus integrates the notion of prevention which remains the principal approach to the problems encountered in the management of hypertension.

Humans↗
PubMed1998

Management of the hypertensive patient who smokes.

Smoking and arterial hypertension are highly prevalent at the community level. While the coexistence of both risk factors is less frequent, the potentiation of cardiovascular risk when both are present makes the association highly relevant in terms of a preventive approach. There are many interrelationships between smoking and high blood pressure at the clinical, epidemiological and pathophysiological levels. Those demonstrable links compel us to review the usual explanation of the influence of smoking on blood pressure. Pharmacological treatment of the hypertensive patient who smokes must be adapted to the patient's risk profile, using the most efficacious antihypertensive agents. With the exception of nonselective beta-blockers, all the available antihypertensive drugs can be prescribed. Minimal intervention and nicotine replacement constitute the most well tested interventions in helping smokers to quit their habit. Nicotine replacement is currently a well tolerated intervention, even in patients with cardiovascular disease.

Adolescent↗
PubMed1998

Target-organ damage and cardiovascular risk profile in resistant hypertension. Influence of the white-coat effect.

BACKGROUND: It is difficult to draw definite conclusions about the prevalence and clinical characteristics of patients with resistant hypertension because of the heterogeneity of study designs described in published studies. OBJECTIVES: To estimate the prevalence of resistant hypertension, the associated cardiovascular risk factors and the degree of target-organ damage, and to analyze the differences between true resistant hypertension (TRH) and white-coat resistant hypertension (WCRH). DESIGN: Cross-sectional study. METHODS: Patients who visited the Hypertension Clinic with resistant hypertension were sequentially included. Resistant hypertension was defined as an average of three measurements of systolic blood pressure, >/= 160 mmHg or a diastolic blood pressure >/= 95 mmHg, or both, in patients treated with a triple-drug regimen, over at least 2 months. Twenty-four-hour ambulatory blood pressure monitoring and M-mode bi-dimensional echocardiography were performed. WCRH was defined as a mean daytime ambulatory blood pressure </= 135/85 mmHg; patients with higher values were classified as having TRH. RESULTS: Of 1200 hypertensive subjects who visited the clinic, 60 patients with resistant hypertension were included [mean age 59+/-8 years; 38 women (63%)]. Office blood pressure was 173+/-14/100+/- 8 mmHg. Of 36 patients with a good quality echocardiograph, 18 had left ventricular hypertrophy. Twenty cardiovascular events were recorded in 16 patients. Obesity was present in 43% of patients, diabetes in 28%, and hypercholesterolemia in 47%. Hypoalphalipoproteinemia was detected in 18%of the patients, all of whom had TRH (P = 0.01). Nineteen subjects (32%) had WCRH. The subjects with TRH had a higher office systolic blood pressure, greater frequency of hypoalphalipoproteinemia than those who had WCRH and a greater proportion of clinical target-organ damage. CONCLUSIONS: Resistant hypertension is uncommon in clinical practice. Resistant hypertension is associated with multiple cardiovascular risk factors, including left ventricular hypertrophy. A third of patients with resistant hypertension achieve adequate control of their blood pressure outside the physician's office. The proportion of patients with clinical target-organ damage is greater in subjects with TRH than in those with WCRH.

Adult↗
PubMed1996

[Frequency of white coat arterial hypertension in mild hypertension. Profile of cardiovascular risk and early organic involvement].

BACKGROUND: The aim of the present was to study the frequency and characteristics of white coat hypertension (WCH) in a series of individuals with slight hypertension (SH) consecutively attended, as well as to evaluate the degree of organic involvement and the presence of other cardiovascular risk factors. METHODS: One hundred six subjects [mean age 43 +/- 12 years, 51 males (48%)] with SH (diastolic pressure between 90-104 mmHg) who were not receiving pharmacologic treatment and did not have severe organic involvement were included in the study. Systolic/diastolic blood pressure (BP) was (x +/- SD) 150 +/- 12/96 +/- 4mmHg. The basic protocol of the Hypertension Unit was applied with out patient monitorization of BP for 24 hours with a Spacelabs 90202 monitor and a two-dimension echocardiogram with measurements according to the recommendations of the American Society of Echocardiography. WCH was defined as a mean diurnal BP (07:00-23:00 h) under 134/90 mmHg. RESULTS: The frequency of WCH was 46%, being more frequent in those over the age of 40 years [OR: 3.08 (IC 95% 1.26-7.62) p = 0.006]. WCH was associated with total cholesterol >or= 5.2 mmol/l [OR: 2.8 (IC 95% 1.14-6.91)]. No significant associations were observed with cholesterol HDL, LDL, triglycerides, glycemia, family history of high blood pressure, body mass index and smoking. Left ventricular hypertrophy (LVH) was less frequent in WCH (6%) than in maintained hypertension (MH) (18%) (NS), while concentric remodelling was more frequent in WCH (22% and 5%, respectively [p < 0.03]). Microalbuminuria was observed in 50 individuals being >or= 30 mg/24 h in 15% of the WCH and in 30% of the MH. CONCLUSIONS: The frequency of white coat hypertension in subjects with slight hypertension is high. The profile of cardiovascular risk among the patients with white coat hypertension and moderate hypertension is similar.

Adult↗
PubMed1994

[Response of arterial pressure to mental stress in young patients with high or mild arterial hypertension. Does it reflect the changes in arterial pressure observed during its ambulatory monitoring?].

BACKGROUND: The use of cardiovascular reactivity tests in the laboratory is based on their probable capacity to predict blood pressure response in stress situations of everyday life. These responses may be estimated from the values obtained by out patient monitorization or blood pressure (OPMBP). METHODS: OPMBP was carried out over 24 hours by Spacelabs 90202 monitor in 57 subjects from 18-40 years of age with high or slightly high blood pressure (mean blood pressure diagnosed 143 +/- 12/91 +/- 8 mmHg) with a Quetelet index of 25.8 +/- 9 kg/m2. Two mental stress tests were applied: the mental arithmetic test (MAT) and a structured interview (SI) in 38 patients with high or slightly high blood pressure (HBP) and to 18 healthy normotense subjects of the same age group. RESULTS: The increases in systolic BP (SBP) and diastolic BP (DBP) observed during MAT and SI were similar: r = 0.88 and r = 0.68, respectively (p < 0.0001, both). The percentage of hyperreactive subjects, defined as those presenting an absolute increase in SBP > or = 25 mmHg and/or an increase of DBP > or = 15 mmHg was greater between those with slightly high blood pressure (70%) and high blood pressure (43%) in both tests than among the normotense subjects of the control groups (28%) (p < 0.05). Upon study of the relation between response to BP during the mental stress tests and the values of BP obtained with OPBPM, a positive correlation was found between the increase in DBP in MAT and the SI and mean 24 hour DBP (r = 0.39 and r = 0.45, p < 0.025 and p < 0.01, respectively). CONCLUSIONS: The correlation of the absolute increase in systolic and diastolic blood pressure during two different mental stress tests in young subjects with high or slightly high blood pressure is very high. The correlation between the increase in blood pressure to mental stress in the laboratory and the blood pressure values obtained during non invasive out patient monitorization was found to be only intermediate for diastolic blood pressure nad null for systolic blood pressure in this study.

Adolescent↗
PubMed1994

Adverse effects of direct-acting vasodilators.

Direct-acting vasodilating agents enter the vascular smooth muscle cell to cause vasodilatation. For long term treatment of hypertension, the use of these drugs as monotherapy is accompanied by activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system. These counteracting mechanisms limit the antihypertensive efficacy of these drugs, and cause adverse effects such as tachycardia and fluid retention. These adverse effects require treatment with beta-blockers and diuretics. However, there is still an important role for intravenous vasodilator therapy in hypertensive emergencies. In the treatment of chronic heart failure, vasodilator therapy has been an important advance. Combination therapy with hydralazine and nitrates is efficacious in improving survival, but ACE inhibitors have an incremental benefit on survival over this combination.

Humans↗