Biomedical subjects
Publications and source records attributed to P Arroyo.
In a referral perinatal center a detailed study was made of all the perinatal deaths that occurred during 1 year; they were analyzed according to primary diagnoses on the basis of a classification by R. L. Naeye which included the placenta. This method points to the areas in which special efforts at prevention should be made, and it should become a reliable basis for comparison.
The degranulatory activity of estradiol was tested on blood eosinophil leukocytes in vivo and in vitro. Treatment of adult ovariectomized rats with 30 micrograms estradiol/100 g body wt. increased the percentage of degranulated eosinophils from 10% to about 70% at 6 or 24 h after treatment, and increased the rate of in vitro eosinophil degranulation of those eosinophils that were non-degranulated at the time of blood sample collection. The addition of estradiol to blood samples from untreated ovariectomized rats (0.05 micrograms/ml) increased the percentage of eosinophils degranulated in vitro at 1 h of incubation from 20% to near 60%. It is suggested that estrogen acts directly on the eosinophils, probably via specific hormone receptors. Considering the hypothesis that eosinophils are involved in the mediation of a group of responses to estrogen in the uterus, it is proposed that the hormone-induced degranulation of these cells may have physiological implications in the regulation of the intensity and duration of the eosinophil-mediated responses. In addition, estrogen-induced eosinophil degranulation may interfere with the action of eosinophils that have migrated to other target organs (lymphoid organs, etc.) under the action of other agents (glucocorticoid hormones, histamine, etc.) or conditions (immune reactions, etc.).
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Thirty-five placentas of small-for-dates infants were compared with control placentas of normally grown infants. They were small by weight, area, and volume and tended to have a marginal cord insertion; marginal cord insertion was associated with a thick cord, and central insertion, with a thin cord. When the two groups were compared, the first showed increased fibrinoid deposits and atherosis, more severe fetal abnormalities, and abnormal nutrition in the mother, together with a high incidence of preeclampsia. In the mothers of both groups, peak diastolic blood pressure was lower than that in the control group; additional factors leading to a probable reduction in placental blood flow were different in the two groups.
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This paper presents the results of a dietary survey (weighed intake/24 hr) carried out in 64 pregnant women living in Huamantla, Tlaxcala, Mexico and its proximities, during November 1973. The primary objective of the study was to identify social indicators with predictive value in relation to food consumption patterns, in order to detect groups at risk of having an inadequate intake. A subgroup of the women (15 cases) had adequate levels of energy and protein intake (E/P intake) when compared to the recommendations established by FAO/OMS, 1973, although they consumed a diet with relatively few variations which was also low in fat content. Family organization was the socioanthropological variable which had the greatest relationship with E/P intake. The extended families presented a better E/P ratio than the nuclear families. Interestingly, the per capita expenditure did not show a significant association with nutritional indicators. These data suggest, therefore, that in the population studied the E/P ratio is more closely associated with family organization than with its income level.
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The frequency of structural chromosomal aberrations in two samples (AM and PM of the same day) from each of nine normal subjects, cultured in two different laboratories, was studied by six observers. The results were analyzed in order to determine the relative importance of inter- and intralaboratory factors in the variability of chromosomal abnormalities. In addition to the difference in the frequency of the abnormalities between the subjects studied, there were differences due to observers from different laboratories (P less than 0.01), as well as between laboratories (P less than 0.01). These results could be explained in part by insufficient agreement between observers from different laboratories and by differences in the quality of the method used.
1. Total skinfold thicknesses (sum of seven sites) were measured in fifty-seven pregnant women with low energy and protein intake, at weeks 24, 30 and 35 of gestation. 2. Women were classified in two groups (overweight and low weight), according to their weight-for-height at week 24 of gestation. 3. Half of the women did not increase, or even reduced the amount of subcutaneous fat during the observation period. The lowest mean value of total skinfold thickness was found in the low-weight women who showed a reduction of the subcutaneous fat. 4. This finding shows that a significant proportion of malnourished women do not follow the average pattern of subcutaneous fat accumulation seen in healthy pregnant women without food intake restriction, during the second half of pregnancy.
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The non-heme iron, folates, and vitamin B12 in the liver of 77 fetuses were assayed as were serum levels of these metabolites in 70 of their mothers. The findings indicate the existence of independent placental transport mechanisms, switched on and off at different stages of late gestation, and peculiar to each metabolite.
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