Viral encephalitic pathogenesis of Huntington's chorea?
Explore the source record for details and available documents.
Encephalitis↗
Biomedical subjects
P Averback
Publications and source records attributed to P Averback.
Seminiferous tubule hypercurvature: A newly recognised common syndrome of human male infertility.
Testicular biopsy specimens from 42 of a series of 70 consecutive cases of primary male infertility and from 25 normal controls were morphometrically analysed. Although all the specimens from infertile males were normal by conventional histological standards, stereological measures of curvature in histological sections showed that cases of idiopathic male infertility had an abnormally increased curvature of seminiferous tubules.
Animals↗
Metastatic intracranial seminoma.
A metastatic seminoma of the right temporal fossa, with facial pain, extraocular paresis, otitis, and abdominal symptoms, was found in a 34-year-old man one year after orchidectomy for a primary testicular tumor that had been treated by surgery and radiotherapy. This is an unusual intracranial metastatic tumor that merits active treatment.
Adult↗
Spheroidal filamentous inclusion body cells in von Recklinghausen's disease.
Cells with spheroidal filamentous cytoplasmic bodies, distinctive by both light and electron microscopy, were found in a neoplasm arising from the sciatic nerve of a patient with von Recklinghausen's disease. Tissue fixed with formalin and embedded in paraffin for three years was deparaffinized, reprocessed, and examined with the electron microscope. The morphology of the spheroidal body cells, the close resemblance to erythrophagocytosis, and the possible significance of the changes are discussed.
Erythrocytes↗
Corpora amylacea of the lumbar spinal cord and peripheral nervous system.
Tissue from L-4 spinal cord, dorsal root ganglia, sural nerve, and intramuscular branches to the gastrocnemius was obtained during 35 random autopsies, embedded in paraffin, and stained with PAS and Holmes Alcian blue and studied for the incidence and distribution of corpora amylacea (CA). Intraaxonal CA in spinal grey matter were commonly found, but the incidence in root ganglia, sural, and intramuscular nerve was low. Clinically insignificant intraneuronal spinal grey CA were found in six of eight men past the age of 60 years. Corpora amylacea in spinal white matter were most common in the region of posterior root entry.
Age Factors↗
Primary cerebral venous thrombosis in young adults: the diverse manifestations of an underrecognized disease.
Primary cerebral venous thrombosis has a wide clinical and pathological spectrum, which has not been recognized. Seven cases of aseptic cerebral venous thrombosis (5 fatal) are discussed, with pathological study and literature review. Five patients ranged in age from 22 to 31 years. In 3 cases no discernible cause for thrombosis was found. Novel features of these cases include: primary bilateral internal cerebral venous thrombosis; isolated thrombocytopenia; occurrence in the context of (1) ulcerative colitis plus oral contraceptive use, (2) a twin transfusion syndrome, and (3) presenting syndrome five years after mastectomy for carcinoma. Diagnosis and treatment are discussed, and it is suggested that a focal coagulopathy may be responsible for this underdiagnosed condition.
Adult↗
Mixed intracranial sarcomas: rare forms and a new association with previous radiation therapy.
The first two instances of mixed sarcoma-glioblastoma with a history of therapeutic irradiation to the head are reported, both occurring within one year of radiation therapy (for pituitary adenoma and residual meningioma). Two novel variants of mixed sarcomas of brain with extreme tumor metaplasia (fibromyxoosteochondrosarcoma and fibrochondroosteosarcoma-glioblastoma multiforme) are documented, and some of the problems concerning the origin of brain tumors with mixed population are discussed.
Adult↗
Congenital absence of the heart: observation of human funiculopagous twinning with insertio funiculi furcata, fusion, forking, and interpositio velamentosa.
An anatomic and radiologic study of a normal and acardius twinning with a single placenta is presented with literature review. The fetus was unusually well-developed with an almost normal skeletal and brain formation, a normal genito-urinary tract, and an absence of liver, spleen, lungs, and pancreas. The heart was absent but the great arteries, single aorta, and veins were present. The placentation is described as funiculopagous with insertio funiculi furcata, fusion, forking and interpositio velamentosa, and the latter may account for the fusion of the two circulations in this instance with the possibility that the heart was never present. The present and other observations of funiculopagous twins with two amniotic sacs suggest that the forked cord twin anomaly may occur earlier than generally recognized.
Abnormalities, Multiple↗
Leukotic spread: an unusual tumor transition.
This report concerns a case of lung cancer, which is of interest because it proves that an epithelial tumor is capable of spreading in a manner morphologically identical to that of a malignant lymphoreticular tumor.
Adenocarcinoma, Bronchiolo-Alveolar↗
Miliary fungal granulomata confined to the brain: mechanism of meningitis.
An unusual case of multiple giant cell granulomata due to Candida albicans confined to the brain of a premature neonate is reported, with evidence to suggest that this fungal meningitis is preceded by a parenchymal focus.
Brain Diseases↗
A human tubular array plasma cell.
A human plasma cell is described which is distinct with both the light and electron microscope. With indirect immunofluorescence its cytoplasm is immunoglobulin-associated and the ultrastructure is characterized by tubular arrays of endoplasmic reticulum similar to those described in a number of diseases. Hypotheses regarding these tubular structures are reviewed.
Aged↗
Pericarditis as a manifestation of essential thrombocythemia.
A 58-year-old woman presented with pericarditis and pericardial effusion. Investigation revealed that she was suffering from a thrombocythemic myeloproliferative disorder; she died of massive pulmonary embolism 10 days after admission. Histologic study verified epicardial and pericardial trilineage hematopoiesis. Pericarditis is an unusual feature of essential thrombocythemia and it may occur in direct relation to the abnormal cellular proliferation.
Female↗
Monochorionic, monoamniotic, double-battledore placenta with stillbirth and postpartum cerebellar syndrome.
Explore the source record for details and available documents.
Adult↗
Hashimoto's thyroiditis with immunoblastic lymphadenopathy and unusual "macaroni cells".
Light and electron microscopic study of the thyroid gland and an enlarged cervical lymph node in a 75-year-old woman with Hashimoto's thyroiditis disclosed immunoblastic proliferation in the lymph node, marked by collections of striking round cells positive to periodic acid-Schiff (PAS) staining, immunoblasts and plasmacytoid elements in a vascular, fibrous framework. The PAS-positive cells ("macaroni cells") were distended with whorls of angulated tubular material resembling endoplasmic reticulum. Parafollicular-cell hyperplasia and an atypical plasmacytoid focus were noted in the thyroid. Hashimoto's disease is known to be associated with malignant lymphoma, as are autoimmune and malignant diseases with immunoblastic lymphadenopathy. This is the first report of the association of Hashimoto's disease and immunoblastic lymphadenopathy. The atypical plasma cells have not previously been described.
Aged↗
Epileptogenic mineralization: pathological variants with good prognosis.
Four examples of grossly mineralized lesions of the brain, causing seizures, are described; they include 2 hamartomas, a choristoma (novel associations), and an idiopathic "brain stone." Each was detectable with routine roentgenograms, and the seizures were ameliorated by surgical therapy.
Adolescent↗
Developmental arachnoid cysts of the posterior fossa-an analysis of 13 cases.
Thirteen cases of posterior fossa arachnoid cyst are described. Presenting features were usually headache, vomiting, lethargy, and delayed development in infants. Association with congenital defects is sometimes noted. The cysts are considered to result from abnormalities occurring in foetal life.
Adolescent↗
Congenital hepatic fibrosis: asymptomatic adults without renal anomaly.
Two cases with the pathologic changes of congenital hepatic fibrosis are described in asymptomatic adults without renal anomaly, Foci of necrosis adjacent to abnormal portal areas suggest that the lesion may not be congenital. It is also suggested that this variant of the disorder may be more common than generally recognized.
Adult↗
Unusual cause of subclavian-steal syndrome [ letter].
Explore the source record for details and available documents.
Adult↗