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P Aylett

Publications and source records attributed to P Aylett.

7 recordsLinked to original sources
PubMed1982

Methadone dose assessment in heroin addiction.

Withdrawal, with measurement of systolic BP and pulse rate, was observed during administration of methadone mixture to heroin addicts after a drug fast of 12 to 24 h. Four subjects were regarded as nonaddicts. In the remainder, there was significant reduction of systolic BP without a titration end point. Nonaddicts and mildly and moderately addicted subjects could be differentiated after a 10-mg dose of methadone. It is hypothesized that tolerance to methadone resembles immunity comparable to that against infections, and not a dose-response curve. Factors making oral methadone less preferable to needle-using addicts include delayed gastric emptying, first passage through the liver, and possible endogenous endorphin/encephalin response. Further studies are suggested.

Administration, Oral↗