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Biomedical subjects

P B Allen

Publications and source records attributed to P B Allen.

46 records · Page 3Linked to original sources
PubMed1984

Third ventricle choroid plexus carcinoma.

Benign and malignant tumors of the choroid plexus in infancy are extremely uncommon. Diagnosis and management of a malignant tumor is described and the literature survey of the problem is presented.

Carcinoma↗
PubMed1975

Non-tumoral stenosis of the aqueduct in adults.

Nine cases of non-tumoral stenosis of the aqueduct in adults are described. The deformed aqueducts are displayed diagrammatically. Patients may be divided into three groups, according to their presentation; papilledema with raised intracranila pressure, epilepsy, or intellectual impairment. Those patients in the first category tended to be younger, and to respond more favorably to treatment. A review of the literature is made.

Adolescent↗
PubMedDate not supplied

Impaired conditioned taste aversion learning in spinophilin knockout mice.

Plasticity in dendritic spines may underlie learning and memory. Spinophilin, a protein enriched in dendritic spines, has the properties of a scaffolding protein and is believed to regulate actin cytoskeletal dynamics affecting dendritic spine morphology. It also binds protein phosphatase-1 (PP-1), an enzyme that regulates dendritic spine physiology. In this study, we tested the role of spinophilin in conditioned taste aversion learning (CTA) using transgenic spinophilin knockout mice. CTA is a form of associative learning in which an animal rejects a food that has been paired previously with a toxic effect (e.g., a sucrose solution paired with a malaise-inducing injection of lithium chloride). Acquisition and extinction of CTA was tested in spinophilin knockout and wild-type mice using taste solutions (sucrose or sodium chloride) or flavors (Kool-Aid) paired with moderate or high doses of LiCl (0.15 M, 20 or 40 mL/kg). When sucrose or NaCl solutions were paired with a moderate dose of LiCl, spinophilin knockout mice were unable to learn a CTA. At the higher dose, knockout mice acquired a CTA but extinguished more rapidly than wild-type mice. A more salient flavor stimulus (taste plus odor) revealed similar CTA learning at both doses of LiCl in both knockouts and wild types. Sensory processing in the knockouts appeared normal because knockout mice and wild-type mice expressed identical unconditioned taste preferences in two-bottle tests, and identical lying-on-belly responses to acute LiCl. We conclude that spinophilin is a candidate molecule required for normal CTA learning.

Animals↗