PubMed Health⌕ Search

Biomedical subjects

P B Beeson

Publications and source records attributed to P B Beeson.

At least 37 records · Page 2Linked to original sources
PubMed1980

The natural history of medical subspecialties.

Factors that have favored the division of the field of internal medicine into numerous subspecialties during the past three decades are reviewed. Some specialty areas are suited almost exclusively to academic clinical investigators, whereas others can be the basis for private practice. Some requisites for viability as a practice subspecialty are listed. It is suggested that in the coming decade the pendulum of preference is likely to swing back somewhat, with a larger fraction of young internists choosing to be identified as practicing general internal medicine rather than limiting their work to a single subspecialty.

Internal Medicine↗
PubMed1977

Protective role of complement in experimental Escherichia coli endocarditis.

Fourteen strains of Escherichia coli were tested for ability to cause infective endocarditis in rabbits prepared by prior placement of an intracardiac catheter. Strains that were resistant to the bactericidal action of serum caused E. coli endocarditis in 91.4% of rabbits, whereas serum-sensitive strains usually failed to cause persisting infection (11.3% infected, P less than 0.001). Although serum-sensitive E. coli lodged on heart valves within 1 h after intravenous injection, they survived less than 24 h in most normal rabbits. In contrast to normals, all five C6-deficient rabbits injected with a serum-sensitive strain of E. coli developed infective endocarditis (P less than 0.005). No correlation was found between the presence of K1 antigen and the incidence of experimental E. coli endocarditis. Thus, the ability of strains of E. coli to establish persisting endocardial infection in rabbits appears to be directly associated with resistance to the complement-mediated serum bactericidal system. These findings may explain in part the rarity of gram-negative bacillary endocarditis in patients; they also indicate that in certain special circumstances the serum bactericidal system can play a decisive role in host defense.

Animals↗
PubMed1977

The eosinophil.

Explore the source record for details and available documents.

Adrenal Cortex Hormones↗
PubMed1975

Reversible granulocyte killing defect in anorexia nervosa.

Three patients are described with anorexia nervosa in whom malnutrition was present with neutropenia and a granulocyte bactericidal degect. Their peripheral blood granulocytes were found to have a reduced rate of killing of Staphylococcus aureus and E. coli in vitro. The opsonic activity of the patients' sera towards Staphylococcus aureus was normal. One of these patients had recurrent episodes of infection which stopped after she had gained 13 kg in weight. Clinical recovery was associated with a return of granulocyte function to normal. It is concluded that granulocyte bactericidal capacity towards a variety of bacteria may be reduced in patients with anorexia nervosa who have malnutrition. This type of acquired granulocyte bactericidal deficiency appears to be reversible.

Adolescent↗
PubMed1974

John Rodman Paul.

Explore the source record for details and available documents.

Epidemiology↗