Biomedical subjects
P B Kristensen
Publications and source records attributed to P B Kristensen.
Eosinophilic cystitis simulating invasive bladder carcinoma.
A case of eosinophilic cystitis simulating an invasive bladder carcinoma is reported. The disease had a subacute course and was associated with arthritis of the symphysis pubis and both sacroiliacal joints.
Simultaneous presentation of a small-cell carcinoma involving the ovary and the uterine endometrium.
A case of simultaneous presentation of a small-cell carcinoma involving the ovary and the uterine endometrium is reported. We consider the endometrium as the primary localization of the tumor. The epithelial origin and neuroendocrine differentiation were confirmed by electron microscopy. Tumor cells were attached by small desmosomes, and in the cytoplasm typically neurosecretory granules measuring 100-200 nm were found. Immunohistochemically, no content of polypeptide hormones (ACTH, Calcitonin, Gastrin, Glucagon, Insulin, Somatostatin and VIP) were encountered. The tumor stained strongly for neuronspecific enolase. The histogenetic possibilities are shortly presented.
[Breast cancer metastasizing to the uterus].
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Flow cytometric classification of biopsy specimens from cervical intraepithelial neoplasia.
The distribution of single-cell DNA content was investigated in biopsy specimens from the human cervix of 121 women suspected of having intraepithelial neoplasia. Comparison of the results of the histopathological examination with the ploidy level showed that all normal specimens were diploid. Thus, no false-positive results occurred. Most of the specimens classified as mild and moderate dysplasia were diploid as well. Aneuploid cell populations occurred in 78% of the lesions classified as severe dysplasia and carcinoma in situ. The ploidy level distribution permitted a natural division of the aneuploid cell populations into two groups with DNA indices either above or below 1.5. The importance of the aneuploidy in carcinogenesis is discussed.
Metastases to the breast from extramammary carcinomas.
Metastases to the breast from extramammary carcinomas are rare. Only about 200 cases are reported in the literature. Fifteen additional cases are presented here and the literature is reviewed. Two of the patients has primary thyroid carcinoma, two adenocarcinoma of the colon, three bronchogenic carcinoma, four malignant melanoma, one a squamous cell carcinoma of the oesophagus, one an adenocarcinoma of the stomach, one a renal cell carcinoma and one a carcinoid of the terminal ileum. In three cases the breast lesion was the first manifestation of an extramammary cancer. Six of the patients died of disseminated cancer shortly after the breast metastasis was diagnosed. Although breast metastasis may be suspected clinically, exact histological diagnosis is important in order to avoid unnecessary surgical treatment and to guide further therapy.
Liposarcoma of the breast. A case report.
Two cases are reported of liposarcoma of the breast, the first in a 62, and the second in a 60-year-old woman, respectively. The tumours were of the poorly differentiated, pleomorphic type and predominantly myxoid type, respectively. Liposarcoma of the breast is extremely rare, and including the present two cases, only 32 patients suffering from the condition have been described. It is difficult to make any prognosis owing to the small number of cases reported. Patient No. 1 in the present work, died 14 months postoperatively, owing to widespread metastatic tumour tissue infiltration of the spine, liver, as well as, the lungs; No. 2 lived for 17 years without signs of recurrence, until she died of carcinoma of the opposite breast.