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P B MARSHALL

Publications and source records attributed to P B MARSHALL.

14 recordsLinked to original sources
PubMed1962

Relationship between anti-acetylcholine and anti-Tremorine activity in anti-parkinsonian and related drugs.

The anti-acetylcholine potency of a number of anti-Parkinsonism drugs and related phenothiazine compounds was determined using the isolated guinea-pig ileum. The antagonism was assessed by the difference between the pA(2) and pA(10) values and by log concentration-response curves for acetylcholine in presence and absence of the antagonists. All compounds except chlorpromazine showed some evidence of competitive antagonism to acetylcholine. The anti-tremor potency of the compounds was assessed from suppression of Tremorine-induced tremors in mice. There was a relation between anti-acetylcholine and anti-Tremorine potency among the anti-Parkinsonism drugs, but not among the phenothiazine compounds. Some implications of the findings are discussed in relation to the mode of action of anti-Parkinsonism drugs.

Acetylcholine↗
PubMed1961

Effect of sex hormones on the excretion of free histamine by male and female rats.

The excretion of free histamine by male rats was increased 10-fold by treatment with oestrogen or castration. That of female rats was reduced to 1/10 by treatment with testosterone. Ovariectomy further increased the histamine excretion by female rats, which was slightly reduced by treatment with oestrogen, and at oestrus. The low level of free histamine excretion by male rats was not increased by compound SKF 525-A, and inhibition of diamine oxidase by aminoguanidine caused the same proportionate increase in both sexes. It is concluded that the conjugation of histamine by male rats requires the presence of androgens, and some preliminary indication is given regarding the possible mechanisms involved.

Amine Oxidase (Copper-Containing)↗
PubMed1956

BZ 55 in diabetes.

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Diabetes Mellitus↗